DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and HA8

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_189850.1	Gene:	HA8 / 823281	AraportID:	AT3G42640	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	971	Identity:	233/971 - (23%)
Similarity:	402/971 - (41%)	Gaps:	211/971 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLF 115
            |::|:| ::|..:|..||::::.:...| |||..:..:.||..|.|.|....:.    ||.|  |
plant     8 DEIKKE-NVDLERIPVEEVFEQLKCSKE-GLSSDEGAKRLEIFGANKLEEKSEN----KFLK--F 64

  Fly   116 GGFAM--LLWI---GAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKI 175
            .||..  |.|:   .||:..|.    |:...:..|...::||::  ::|:....|:.:|:.:...
plant    65 LGFMWNPLSWVMESAAIMAIVL----ANGGGKAPDWQDFIGIMV--LLIINSTISFIEENNAGNA 123

  Fly   176 MES-FKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGE 239
            ..: ..|:.|: ..|:|:|:.....|..||.||::.:|.||.:|||.|::|....|:|.|:||||
plant   124 AAALMANLAPK-TKVLRDGKWGEQEASILVPGDLISIKLGDIVPADARLLEGDPLKIDQSALTGE 187

  Fly   240 SEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAK 304
            |.|       |.::|.:.   .|..:...:|..:.|||:.|.||..|:.|.|...        ..
plant   188 SLP-------TTKHPGDE---VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDS--------TN 234

  Fly   305 EIHHFIHLITGVAVF------LGVTFFVIAFILGYH--WLDAVIFLIGIIVANVPEGLLATVTVC 361
            .:.||..::|.:..|      ||:...::......|  :.|.:..|:.:::..:|..:...::|.
plant   235 NVGHFQKVLTSIGNFCICSIGLGMLIEILIMYPIQHRTYRDGIDNLLVLLIGGIPIAMPTVLSVT 299

  Fly   362 LTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSG 426
            :.:.:.|::.:..:.|.:.|:|.:.....:|||||||||.|:::|     |..:||.......|
plant   300 MAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV-----DKSLIEVFPKNMDS- 358

  Fly   427 VQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKR 491
                         ..:..:..||.....||.:         |||...:       |||....|..
plant   359 -------------DSVVLMAARASRIENQDAI---------DASIVGM-------LGDPKEARAG 394

  Fly   492 NKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAF 556
            ..::..:|||..:| :.:|...:::.|  :....|||||:|:|.|:   :.|:.|....|:.:.|
plant   395 ITEVHFLPFNPVDK-RTAITYIDESGD--WHRSSKGAPEQIIELCN---LQGETKRKAHEVIDGF 453

  Fly   557 NNAYMELGGLGERVLGFCDFMLP-----SDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAA 616
            ...       |.|.||.....:|     ||..|                ..||||:.:.||||..
plant   454 AER-------GLRSLGVAQQTVPEKTKESDGSP----------------WEFVGLLPLFDPPRHD 495

  Fly   617 VPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISE--------GNETVEDIAQRLNIPVSEV 673
            ..:.:.:....|:.|.|:|||.........:.:|:.:.        ||...|.:   :.||:.|:
plant   496 SAETIRRALELGVNVKMITGDQLAIGIETGRRLGMGTNMYPSTSLLGNSKDESL---VGIPIDEL 557

  Fly   674 NPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVN 738
                        .|..|                .||...|:.|..||:..|....|..:||||||
plant   558 ------------IEKAD----------------GFAGVFPEHKYEIVKKLQERKHICGMTGDGVN 594

  Fly   739 DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP 803
            |:|||||||||:|:..| :|.::.|:|::|.:...:.|::.|...|.||..:|....|.::..|.
plant   595 DAPALKKADIGIAVADA-TDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIR 658

  Fly   804 EISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMK---RPPRDPFNDKLVNS 865
            .:..|:...|           |...|....||..|::..:.....|.|   :|...|.:.||..
plant   659 IVLGFMLVAL-----------IWRFDFAPFMVLIIAILNDGTIMTISKDRVKPSPVPDSWKLNE- 711

  Fly   866 RLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRK 930
               ..|.|.:.....|....::|.:..:..|. .|.||:|.:..:
plant   712 ---IFATGVVLGTYMALTTVLFFWLAHDTDFF-SKTFGVRSIQGN-------------------- 752

  Fly   931 TLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWAL----NFGLVFETVLAAFLS 987
              |.....|.::.:.::..|.:.:.::          |:|:.    .|.|:...|:|..::
plant   753 --EEELMAALYLQVSIISQALIFVTRS----------RSWSFVERPGFLLLIAFVIAQLVA 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	233/971 (24%)
		Cation_ATPase_N	58..132	CDD:214842	23/78 (29%)
		E1-E2_ATPase	152..383	CDD:278548	58/239 (24%)
		Cation_ATPase	445..539	CDD:289987	25/93 (27%)
		COG4087	<695..770	CDD:226572	30/74 (41%)
		Cation_ATPase_C	817..1025	CDD:279079	29/178 (16%)
HA8	NP_189850.1	Cation_ATPase_N	14..86	CDD:214842	23/78 (29%)
		ATPase-IIIA_H	35..807	CDD:273731	225/942 (24%)
		E1-E2_ATPase	100..321	CDD:278548	59/241 (24%)
		Cation_ATPase	<379..436	CDD:289987	19/66 (29%)
		COG4087	<549..634	CDD:226572	36/116 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910