Protein Alignment Atpalpha and atp1a1a.2

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_571762.1
• Gene: atp1a1a.2 / 64613
• ZFINID: ZDB-GENE-001212-2
• Length: 1023
• Species: Danio rerio
• Alignment Length: 1029
• Identity: 726/1029 - (70%)
• Similarity: 864/1029 - (83%)
• Gaps: 13/1029 - (1%)

  Fly    13 DSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHP 77
            |.||: |..:.|:..:|..|:            :|:::|:||:|:::|.||::.:||.:::.|..
Zfish     8 DDYRL-TPTSEDELKKTKKGK------------RKKDVDELKKEVELDDHKLTLDELSRKYGTGM 59

  Fly    78 ENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEE 142
            ..|||..:|||.||||||||||||..||:||||||.|||||..|||.||.|||:||.||.::.|:
Zfish    60 IKGLSSFRAKEILERDGPNALTPPPTTPQWVKFCKLLFGGFQTLLWFGAFLCFLAYGIQVASVED 124

  Fly   143 PADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGD 207
            .|.||||||:||:.||||.|.||:|||||||||||||:|:|||.|.|:|:|||..:.||::|:||
Zfish   125 AAHDNLYLGLVLAFVVIVNGWFSFYQESKSSKIMESFRNLVPQQALVVRDGEKKVINAEEVVVGD 189

  Fly   208 VVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTA 272
            ::||..|||||||:||:.|:..||||||||||||||||..||:|||||||||:||||||.|||||
Zfish   190 LIEVCGGDRIPADLRIVYAQGCKVDNSSLTGESEPQSRSPEFSHENPLETKNIAFFSTNCVEGTA 254

  Fly   273 KGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLD 337
            :|:.||.||.|:|||||.|||.|:.|:||||:||.||||:|:.|::||||||||::.||||.|::
Zfish   255 RGIAISTGDRTIMGRIASLASSLEGGQTPIAREIEHFIHIISAVSIFLGVTFFVLSLILGYAWIE 319

  Fly   338 AVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQN 402
            ||:||||||||||||||.|||||||||||||||.|||||||||||||||||:|||||||||||||
Zfish   320 AVVFLIGIIVANVPEGLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQN 384

  Fly   403 RMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSG 467
            ||||||||||:||.||||||:|||..:||:||.:.||:|:|.|||||.|:..|..:|:|.:|.:|
Zfish   385 RMTVAHMWFDSQIHEADTTENQSGTSFDRSSPTWAALARVAGLCNRAVFRAEQSHLPVLNRETAG 449

  Fly   468 DASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERI 532
            ||||:|||||:||..|.|:.:|::.:||.|:|||||||||:|:|:...::..::|||||||||||
Zfish   450 DASESALLKCIELCCGSVIEMREKYRKICEIPFNSTNKYQLSVHKNPSSSGTKHLLVMKGAPERI 514

  Fly   533 LERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFP 597
            |:|||||.|||||:.:|:|.|::|.:||:|||||||||||||.:.||.|::|.||.|:.:|:|||
Zfish   515 LDRCSTILINGKEQPMDDENKDSFQSAYVELGGLGERVLGFCQYNLPDDQFPEGFAFDPEDVNFP 579

  Fly   598 IDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDI 662
            .:||.|:|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
Zfish   580 TENLCFLGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDI 644

  Fly   663 AQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMG 727
            |.|:||||.|||||||||.||||.||::::...||||||||||||||||||||||||||||||.|
Zfish   645 AARMNIPVGEVNPREAKACVVHGGELKNMNDSDLDEILRYHTEIVFARTSPQQKLIIVEGCQRQG 709

  Fly   728 AIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 792
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   710 AIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 774

  Fly   793 SIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDP 857
            ||||||||.|||:||||.|::..|||||||||||.||||||::||||.|||:||.|||||.||:.
Zfish   775 SIAYTLTSKIPEMSPFLMFVVVGIPLPLGTVTILFIDLGTDLIPAISYAYENAENDIMKRQPRNA 839

  Fly   858 FNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQ 922
            ..|:|||.|||||||||||||||.||||.|..:||||||.|..|.|:|..|:.:::.||.|||||
Zfish   840 QKDRLVNERLISMAYGQIGMIQAVAGFFTYITVMAENGFRPSYLPGLRVGWEDRSIGDLEDSYGQ 904

  Fly   923 EWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLS 987
            :|||..||.:|.||||||||||||||||||:|.|||||||.||||:|..|.|....|..||||||
Zfish   905 QWTYEGRKIIESTCHTAFFISIVVVQWADLLIVKTRRNSILQQGMKNKVLIFAFFEEGALAAFLS 969

  Fly   988 YCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            |||||:..:|||||:.:|||.|:|:||.||.|||.|::.|||||||::|:||||
Zfish   970 YCPGMDIAVRMYPLRPLWWFTALPYALIIFFYDEIRKYILRRNPGGFVEKETYY 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	717/995 (72%)
atp1a1a.2	NP_571762.1	ATPase-IIC_X-K	31..1023	CDD:273445	716/991 (72%)