DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp1a3b

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_571760.2	Gene:	atp1a3b / 64611	ZFINID:	ZDB-GENE-001212-8	Length:	1023	Species:	Danio rerio

Alignment Length:	1033	Identity:	785/1033 - (75%)
Similarity:	894/1033 - (86%)	Gaps:	12/1033 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HGRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRF 73
            :||:|||||||.            |.|..:..|.|....::|||||:|:.:..||:|.||:.::|
Zfish     3 YGRSDSYRVATT------------QDKDEKGSPKKKKGAKDLDDLKKEVPLTEHKMSVEEVCRKF 55

  Fly    74 QTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAS 138
            ||....||::|||::.|.||||||||||..||||||||:.|||||::||||||||||:||:|||:
Zfish    56 QTDIVQGLTNAKARDFLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYAIQAA 120

  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDL 203
            |.::||.||||||||||||||:||.|||:||:|||||||||||||||.|.|||||||:.:.||::
Zfish   121 TEDDPAGDNLYLGIVLSAVVIITGCFSYFQEAKSSKIMESFKNMVPQQALVIREGEKMQINAEEV 185

  Fly   204 VLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAV 268
            |.||:||||.|||||||:|||.|...||||||||||||||:|..:.||:|||||:|:||||||.|
Zfish   186 VAGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNIAFFSTNCV 250

  Fly   269 EGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGY 333
            ||||:|||:..||.|||||||.|.|||:||:|||||||.||||:||||||||||:||::|.||||
Zfish   251 EGTARGVVVCTGDRTVMGRIATLTSGLETGKTPIAKEIEHFIHIITGVAVFLGVSFFILAVILGY 315

  Fly   334 HWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGT 398
            .||:|||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Zfish   316 TWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGT 380

  Fly   399 LTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKK 463
            ||||||||||.||||||.||||||||||..:|::|..:.||:|:|.|||||.||.|||.:||||:
Zfish   381 LTQNRMTVAHKWFDNQIHEADTTEDQSGASFDKSSVTWVALARVAALCNRAVFKAGQDSLPILKR 445

  Fly   464 EVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGA 528
            :|:|||||:|||||:||:.|.|..:|::|||:||:|||||||||:|||||||.||.|||||||||
Zfish   446 DVAGDASESALLKCIELSSGSVKAMREKNKKVAEIPFNSTNKYQLSIHETEDNNDNRYLLVMKGA 510

  Fly   529 PERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDD 593
            |||||:|||||.:.|||:.:||||||||.|||:|||||||||||||..::|.|:||.||.|:|||
Zfish   511 PERILDRCSTIMLQGKEQPMDEEMKEAFQNAYLELGGLGERVLGFCHVLMPEDQYPKGFAFDTDD 575

  Fly   594 INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNET 658
            :||..|||.|||||||||||||||||||.|||||||||||||||||||||||||.||||||||||
Zfish   576 VNFQTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNET 640

  Fly   659 VEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGC 723
            |||||.|||||||:||||:|||.|:||.:|:|.|.:|:||:||.|||||||||||||||||||||
Zfish   641 VEDIAARLNIPVSQVNPRDAKACVIHGTDLKDYSQEQIDEVLRNHTEIVFARTSPQQKLIIVEGC 705

  Fly   724 QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 788
            ||.||||||||||||||||||||||||||||:||||||||||.||||||||||||||||||||||
Zfish   706 QRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADTILLDDNFASIVTGVEEGRLIFD 770

  Fly   789 NLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRP 853
            |||||||||||||||||:|||.||:.:|||||||:||||||||||||||||||||.||:|||||.
Zfish   771 NLKKSIAYTLTSNIPEITPFLLFIIVNIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQ 835

  Fly   854 PRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTD 918
            ||:|..|||||.||||:||||||||||..|||.||||:|||||||..|.|||..||.:|:|||.|
Zfish   836 PRNPMRDKLVNERLISIAYGQIGMIQALGGFFAYFVILAENGFLPSLLVGIRLNWDDRAMNDLED 900

  Fly   919 SYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLA 983
            ||||:|||..||.:|:|||||||:|||||||||:|||||||||:|||||:|..|.|||..||.||
Zfish   901 SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADVIICKTRRNSVFQQGMKNKILIFGLFEETALA 965

  Fly   984 AFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            |||||||||:..|||||||..|||.|.|::..||:|||.|:..||||||||:|:||||
Zfish   966 AFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEVRKLLLRRNPGGWVEKETYY 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	770/995 (77%)
		Cation_ATPase_N	58..132	CDD:214842	47/73 (64%)
		E1-E2_ATPase	152..383	CDD:278548	183/230 (80%)
		Cation_ATPase	445..539	CDD:289987	70/93 (75%)
		COG4087	<695..770	CDD:226572	68/74 (92%)
		Cation_ATPase_C	817..1025	CDD:279079	156/207 (75%)
atp1a3b	NP_571760.2	ATPase-IIC_X-K	25..1023	CDD:273445	771/997 (77%)
		Cation_ATPase_N	41..114	CDD:214842	47/72 (65%)
		E1-E2_ATPase	134..365	CDD:278548	183/230 (80%)
		Cation_ATPase	427..521	CDD:289987	70/93 (75%)
		COG4087	606..>732	CDD:226572	109/125 (87%)
		Cation_ATPase_C	799..1008	CDD:279079	156/208 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1059
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113729
Inparanoid	1	1.050	1592	1.000	Inparanoid score	I79
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm24672
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980