DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp1a2a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_571758.1	Gene:	atp1a2a / 64609	ZFINID:	ZDB-GENE-001212-6	Length:	1017	Species:	Danio rerio

Alignment Length:	996	Identity:	750/996 - (75%)
Similarity:	866/996 - (86%)	Gaps:	1/996 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKF 110
            |.::||:||:|:.:|.||::.:||..|:......||:|.:|.|.|.||||||||||..|||||||
Zfish    23 KDKDLDELKKEVSLDDHKLTLDELSTRYGVDLARGLTHKRAMEILARDGPNALTPPPTTPEWVKF 87

  Fly   111 CKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKI 175
            ||.|||||::||||||||||:||||||:|.:||.:||||||:|||||||:||.||||||:|||:|
Zfish    88 CKQLFGGFSILLWIGAILCFLAYSIQAATEDEPVNDNLYLGVVLSAVVIITGCFSYYQEAKSSRI 152

  Fly   176 MESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGES 240
            |:||||||||.|.|||:||||.:.||::|.||:||:|.|||:|||:|||.:...|||||||||||
Zfish   153 MDSFKNMVPQQALVIRDGEKLQINAEEVVQGDLVEIKGGDRVPADLRIISSSGCKVDNSSLTGES 217

  Fly   241 EPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKE 305
            |||:|..||||||||||:|::|||||.|||||.|:||:.||||||||||.|||||:.|:|||..|
Zfish   218 EPQTRSPEFTHENPLETRNISFFSTNCVEGTAHGIVIATGDHTVMGRIATLASGLEVGQTPINME 282

  Fly   306 IHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA 370
            |.||||:|||||:|||::||:::.||||.||:|||||||||||||||||||||||||||||||||
Zfish   283 IEHFIHIITGVAIFLGMSFFILSIILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA 347

  Fly   371 SKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPG 435
            .||||||||||||||||||||||||||||||||||||||||||||.||||||||||..:|::||.
Zfish   348 RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGCDFDKSSPT 412

  Fly   436 FKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPF 500
            :.:|||:..|||||.||.||:.:||..::.:|||||:|||||:|:..|:|..:|..|:|:||:||
Zfish   413 WFSLSRVGGLCNRAVFKAGQEEIPIRTRDTAGDASESALLKCVEILSGNVETLRGNNRKVAEIPF 477

  Fly   501 NSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGG 565
            |||||||:||||.|| :...:||||||||||||:|||||.|||.|..:|::..:||..|||||||
Zfish   478 NSTNKYQLSIHELED-SPTGHLLVMKGAPERILDRCSTIMINGVEFPIDDDWMDAFQGAYMELGG 541

  Fly   566 LGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIK 630
            |||||||||...|...::|.||:|:.||:|||::.|.|:||:||:|||||||||||.||||||||
Zfish   542 LGERVLGFCHLFLSPSQFPRGFEFDCDDVNFPVNQLCFLGLISMVDPPRAAVPDAVGKCRSAGIK 606

  Fly   631 VIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQ 695
            |||||||||||||||||.|||||||||||||||:|||||:|:||||||||.||||::|:|:||:.
Zfish   607 VIMVTGDHPITAKAIAKGVGIISEGNETVEDIAERLNIPLSQVNPREAKACVVHGSDLKDMSSEY 671

  Fly   696 LDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVS 760
            ||:|||.|||||||||||||||||||||||.||||||||||||||||||||||||||||.|||||
Zfish   672 LDDILRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGITGSDVS 736

  Fly   761 KQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTI 825
            |||||||||||||||||||||||||||||||||||||||||||||:|||.||:..:|||||||||
Zfish   737 KQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIASVPLPLGTVTI 801

  Fly   826 LCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVI 890
            ||||||||||||||||||.||:|||||.||:|..|||||.|||||||||||||||..|||.||||
Zfish   802 LCIDLGTDMVPAISLAYESAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVI 866

  Fly   891 MAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIIC 955
            ||||||||:.|.|||..||.:.||||.|.|||:|||..||.:|:||||:||:|||||||||||||
Zfish   867 MAENGFLPQTLLGIRLDWDDRTVNDLEDGYGQQWTYEQRKIIEFTCHTSFFVSIVVVQWADLIIC 931

  Fly   956 KTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYD 1020
            ||||||:|||||:|..|.|||..||.|||||||||||:..|||||||::|||.|.|::|.||:||
Zfish   932 KTRRNSVFQQGMKNRILIFGLFAETALAAFLSYCPGMDVALRMYPLKIMWWFCAFPYSLLIFVYD 996

  Fly  1021 ETRRFYLRRNPGGWLEQETYY 1041
            |.|:|.||||||||:|.||||
Zfish   997 EIRKFILRRNPGGWVEIETYY 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	748/994 (75%)
		Cation_ATPase_N	58..132	CDD:214842	46/73 (63%)
		E1-E2_ATPase	152..383	CDD:278548	176/230 (77%)
		Cation_ATPase	445..539	CDD:289987	59/93 (63%)
		COG4087	<695..770	CDD:226572	69/74 (93%)
		Cation_ATPase_C	817..1025	CDD:279079	159/207 (77%)
atp1a2a	NP_571758.1	ATPase-IIC_X-K	34..1017	CDD:273445	742/983 (75%)
		Cation_ATPase_N	35..109	CDD:214842	46/73 (63%)
		E1-E2_ATPase	129..360	CDD:278548	176/230 (77%)
		Cation_ATPase	422..515	CDD:289987	59/93 (63%)
		COG4087	600..746	CDD:226572	130/145 (90%)
		Cation_ATPase_C	793..1002	CDD:279079	159/208 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1059
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1592	1.000	Inparanoid score	I79
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm24672
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	LDO	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840