DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp12a-like

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001025550.1	Gene:	atp12a-like / 594945	XenbaseID:	XB-GENE-5771626	Length:	1033	Species:	Xenopus tropicalis

Alignment Length:	1028	Identity:	631/1028 - (61%)
Similarity:	794/1028 - (77%)	Gaps:	11/1028 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VIATDDDNRTADGQYKSRRKMPAKVNKKEN-----LDDLKQELDIDFHKISPEELYQRFQTHPEN 79
            ::..||.....:   |.:.|:..|  ||.|     :|.||:||:|:.|.:|.|||.:::....:.
Frog    11 IVPMDDQKANTE---KKKNKLFGK--KKGNKSGKKVDTLKKELEINDHNLSIEELEKKYNVDIKV 70

  Fly    80 GLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPA 144
            |.....|.|...|||||.|:|||.|||.|||...:.|||:::.|||:||||:||.:|.:.....:
Frog    71 GQPQQTADELFARDGPNRLSPPKGTPEIVKFMLLMAGGFSIVFWIGSILCFIAYGLQVAQDPTVS 135

  Fly   145 DDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVV 209
            .|||:|.::|.|||::|.:|:||||:||:.||..|||||||.|.|:|:|:::.|.||.||:||:|
Frog   136 KDNLWLALILIAVVVMTALFAYYQEAKSTNIMAGFKNMVPQQALVLRDGKRVELVAEKLVVGDIV 200

  Fly   210 EVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKG 274
            .:|.||:||||:|::|:...||||||||||||||:||.|.|.||||||||||||||..:||||.|
Frog   201 FIKGGDKIPADLRMLESAGCKVDNSSLTGESEPQARGTECTDENPLETKNLAFFSTTCLEGTASG 265

  Fly   275 VVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAV 339
            :||:.||.||:||||.|||.:...:||||.||.||:|:|:|:||.:|:.||:|:..:||..|:|:
Frog   266 IVINTGDRTVIGRIANLASQVGNQKTPIALEIEHFVHMISGLAVGVGILFFIISISMGYSALNAI 330

  Fly   340 IFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRM 404
            ||.|||:||.|||||||||||||:|||||||.||||||||||||||||||.||||||||||||||
Frog   331 IFCIGIVVAYVPEGLLATVTVCLSLTAKRMAKKNCLVKNLEAVETLGSTSVICSDKTGTLTQNRM 395

  Fly   405 TVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDA 469
            |||||||||.|..|||||||||..:|::||.:|||.|||||||||||....:.|||.|::|:|||
Frog   396 TVAHMWFDNIIHNADTTEDQSGEAFDQSSPSWKALLRIATLCNRAEFLACAEDVPINKRQVNGDA 460

  Fly   470 SEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILE 534
            |||||||..|...|:|.::|.||||::|:||||:||||||||..|:..:..|||||||||||||:
Frog   461 SEAALLKFSEQLQGNVSDVRARNKKVSEIPFNSSNKYQVSIHIPENPAEKGYLLVMKGAPERILD 525

  Fly   535 RCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPID 599
            ||.||.|.|:|..|||||||.|.||||.||||||||||||...||.|.|..|:.|:|:::|||:.
Frog   526 RCETIMIAGQEWPLDEEMKENFQNAYMTLGGLGERVLGFCQLSLPHDVYGPGYPFDTENVNFPLS 590

  Fly   600 NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQ 664
            .|.||||:|||||||::|||||.||||:|||||||||||||||||||:.|||||..:|||||||:
Frog   591 GLCFVGLISMIDPPRSSVPDAVMKCRSSGIKVIMVTGDHPITAKAIARCVGIISSTSETVEDIAE 655

  Fly   665 RLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAI 729
            ||.|||.:||||||.|.||:|.|:.|::||:||::||:|.|||||||||||||:|||||||:|||
Frog   656 RLGIPVEQVNPREACACVVNGGEIIDMTSDELDDVLRHHQEIVFARTSPQQKLLIVEGCQRLGAI 720

  Fly   730 VAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSI 794
            |||||||||||||||||||||||||||||.:|.:|||||||||||||||||||||||||||||||
Frog   721 VAVTGDGVNDSPALKKADIGVAMGIAGSDAAKHSADMILLDDNFASIVTGVEEGRLIFDNLKKSI 785

  Fly   795 AYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFN 859
            :||:|.||||:.||:.:::...||||||:|||.|:||||::|:|:||||.||.|||.|.||:|..
Frog   786 SYTVTKNIPEMIPFMVYVIISCPLPLGTITILFIELGTDIIPSIALAYEKAENDIMLRKPRNPRK 850

  Fly   860 DKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEW 924
            |:|||.:|::.:|..|..:::.|||..||.:||:.||||..|.|:|..|:.|.:.:|.|||||||
Frog   851 DRLVNQQLLTYSYFHIAAMESYAGFVNYFTVMAQQGFLPITLIGLRAPWEDKNIQELEDSYGQEW 915

  Fly   925 TYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQG-MRNWALNFGLVFETVLAAFLSY 988
            ||..|...|:.|::||||||||.|..:..|.|||||:|..:. .||..:..||:.:..:..||.|
Frog   916 TYTQRLHQEWYCYSAFFISIVVCQMMNTCIRKTRRNTILSRNFFRNKVIFIGLLSQVAIGVFLCY 980

  Fly   989 CPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||||:..|...|:::.:||.:|.:.:.|.:|||.|:..:|..||.|:::|.||
Frog   981 CPGMDDALHFMPIRVQYWFVSIEYTILILVYDELRKLLIRTFPGSWVDKELYY 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	624/1001 (62%)
		Cation_ATPase_N	58..132	CDD:214842	34/73 (47%)
		E1-E2_ATPase	152..383	CDD:278548	150/230 (65%)
		Cation_ATPase	445..539	CDD:289987	59/93 (63%)
		COG4087	<695..770	CDD:226572	63/74 (85%)
		Cation_ATPase_C	817..1025	CDD:279079	102/208 (49%)
atp12a-like	NP_001025550.1	ATPase-IIC_X-K	42..1033	CDD:273445	621/990 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010