DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and JYalpha

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	662/1002 - (66%)
Similarity:	795/1002 - (79%)	Gaps:	6/1002 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KVN---KKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQT 104
            |:|   ||:::...|::::.|.|||..:||.:|.:|.|..|||..:||..||.:|||.|||...|
  Fly    11 KINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPT 75

  Fly   105 PEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQE 169
            |:|:.|.|.:|||||:|||.|:.||||.|.||..|..||.||||||||.|:.:|||||:|:|:|.
  Fly    76 PKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQV 140

  Fly   170 SKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNS 234
            .|||.||:||||:|||:||||||||..|:.::::|.||:||||||||:||||||:||...|||||
  Fly   141 HKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVDNS 205

  Fly   235 SLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGE 299
            |||||||||.|..|||||||||||||||||||.:|||.:||||:.||.|||||||.||:|||..:
  Fly   206 SLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQ 270

  Fly   300 TPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTL 364
            :||::||..||..||..|:.||::||.|:..|||.::|||:|||||||||||||||.||||||||
  Fly   271 SPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVTVCLTL 335

  Fly   365 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQY 429
            ||||||||||||||||||||||||||||||||||||||||||||:|:|..|:|:||||...|..:
  Fly   336 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGSHF 400

  Fly   430 DRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKK 494
            ......|.||...|.|||.||||||||.:|:.||:|:|:||||||||..|.....:...|:::.|
  Fly   401 KIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKHIK 465

  Fly   495 IAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNA 559
            :.|:|||||.|||||:||. :::|..:::.|||||||||:|||||.|.|....|...:|..|..|
  Fly   466 LTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEA 529

  Fly   560 YMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKC 624
            |:|:||:|||||||.|.:||..|||..::|:.|..|||::||||:||:|:|||||||||||||||
  Fly   530 YLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKC 594

  Fly   625 RSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELR 689
            ||||::||||||||||||||||:|||||:  ..|.||||::..:.|.:::.|:|.|.||||.|||
  Fly   595 RSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELR 657

  Fly   690 DVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGI 754
            ::.:::||.::.||.|||||||||||||||||.|||.|.||||||||||||||||:|||||||||
  Fly   658 EMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGI 722

  Fly   755 AGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLP 819
            :||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|::.||||.
  Fly   723 SGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLA 787

  Fly   820 LGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGF 884
            |||:.|||||:||||:||||||||.||:|||.|.|||||.|:|||.:||.|||.|||:||..|.|
  Fly   788 LGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVACF 852

  Fly   885 FVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQW 949
            |.:|.||||:||.|.:|.|||:.||||.|.||.|.||||||||:||.||||..|.||:||||.|.
  Fly   853 FTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVTQV 917

  Fly   950 ADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFAL 1014
            .||:|||||||||.||||.|..|||.||.|.::|..|.|.|..||.||||.:|.:||..|.||.|
  Fly   918 FDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPFGL 982

  Fly  1015 AIFIYDETRRFYLRRNPGGWLEQETYY 1041
            .||.:||:|||.:|||||||:||||||
  Fly   983 LIFFFDESRRFLIRRNPGGWVEQETYY 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	659/998 (66%)
		Cation_ATPase_N	58..132	CDD:214842	39/73 (53%)
		E1-E2_ATPase	152..383	CDD:278548	165/230 (72%)
		Cation_ATPase	445..539	CDD:289987	53/93 (57%)
		COG4087	<695..770	CDD:226572	63/74 (85%)
		Cation_ATPase_C	817..1025	CDD:279079	136/207 (66%)
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	658/994 (66%)
		Cation_ATPase_N	29..102	CDD:214842	38/72 (53%)
		E1-E2_ATPase	123..354	CDD:278548	165/230 (72%)
		Cation_ATPase	416..509	CDD:289987	53/93 (57%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	137/208 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I532
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I96
Isobase	1	0.950	-	0	Normalized mean entropy	S851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm51342
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	P	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
	10	9.920