DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atpalpha and ATP13A1

DIOPT Version :9

Sequence 1:NP_732572.1 Gene:Atpalpha / 48971 FlyBaseID:FBgn0002921 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_065143.2 Gene:ATP13A1 / 57130 HGNCID:24215 Length:1204 Species:Homo sapiens


Alignment Length:950 Identity:191/950 - (20%)
Similarity:344/950 - (36%) Gaps:252/950 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 VNKKENLDDLKQELDIDFHKIS-PEELYQRFQTHP-----ENGLSHAKAKENLERDGPNALTPPK 102
            :::.|..|.| :.|..:|.||. ..:..::.|..|     .|..|:.::....:.|........|
Human   158 LHRNEGEDGL-EVLSFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKK 221

  Fly   103 --------QTPEWVKFCKN-------LFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGI 152
                    ..|::.:..|.       :|..|.:.||     |.              |:..|..:
Human   222 FGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLW-----CL--------------DEYWYYSV 267

  Fly   153 VLSAVVIVTGIFSYYQESKSSKIMESFKNM--------VPQFATVIREGEKLTLRAEDLVLGDVV 209
            ...::::.         .::|.:.:..:||        .|....|.|..:...:.::::|.||:|
Human   268 FTLSMLVA---------FEASLVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPIASDEIVPGDIV 323

  Fly   210 EVKFGDR---IPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLE--------------T 257
            .:....:   :|.|:.::..|.. ||.:.|||||.||.:       .|:|              .
Human   324 SIGRSPQENLVPCDVLLLRGRCI-VDEAMLTGESVPQMK-------EPIEDLSPDRVLDLQADSR 380

  Fly   258 KNLAFFSTNAVEGT--------AKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLIT 314
            .::.|..|..|:..        .|.|...|..:.       |.:|.:|.:..:.:.|...:..:|
Human   381 LHVIFGGTKVVQHIPPQKATTGLKPVDSGCVAYV-------LRTGFNTSQGKLLRTILFGVKRVT 438

  Fly   315 --GVAVFLGVTFFVIAFI--LGYHW---------------LDAVIFLIGIIVANVPEGLLATVTV 360
              .:..|:.:.|.::..|  ..|.|               |:..:.|..::...:|..|...|..
Human   439 ANNLETFIFILFLLVFAIAAAAYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNT 503

  Fly   361 CLTLTAKRMASKNCLVKNLEAVETL-----GSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADT 420
            .|...||..         :...|..     |.....|.|||||||.:.:.|              
Human   504 SLIALAKLY---------MYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVV-------------- 545

  Fly   421 TEDQSGVQYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPILKKEVSGDASEAALLKCMEL 480
                .||...|.......:|.|....:||     ......||..:      ||..|.|:|..::.
Human   546 ----RGVAGLRDGKEVTPVSSIPVETHRALASCHSLMQLDDGTLV------GDPLEKAMLTAVDW 600

  Fly   481 ALGD-----VMNIRKRNKKIAE-VPFNSTNKYQVSI---HETEDTNDPRYLLVMKGAPERILERC 536
            .|..     ..:|:.:..||.: ..|.|..| ::|:   :|...:.|..|:..:|||||.:....
Human   601 TLTKDEKVFPRSIKTQGLKIHQRFHFASALK-RMSVLASYEKLGSTDLCYIAAVKGAPETLHSMF 664

  Fly   537 STIFINGKEKVLDEEMKEAFNNAYMELGGLGERV--LGFCDFMLPSDKYPNGFKFNTDDINFPID 599
            |             :....:::.:.|:...|.||  ||:.:....:.:.....|....:.     
Human   665 S-------------QCPPDYHHIHTEISREGARVLALGYKELGHLTHQQAREVKREALEC----- 711

  Fly   600 NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV----- 659
            :|:|||.:.:..|.:|.....:.:.::|..:|:|:|||:|:||..:|:.:..|.:.:..:     
Human   712 SLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIEKAHTLILQPPS 776

  Fly   660 --------EDIAQRLNIPVSEVNPREAK---AAVVHGAELRDVSSDQLDEILRY--HTEIVFART 711
                    ..|...:.:|::..:|:...   |..:.|..|..:.:....::||.  |.: ||||.
Human   777 EKGRQCEWRSIDGSIVLPLARGSPKALALEYALCLTGDGLAHLQATDPQQLLRLIPHVQ-VFARV 840

  Fly   712 SPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAM------------------------ 752
            :|:||..::...:.:|.:..:.|||.||..|||.||:|||:                        
Human   841 APKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPTLSNS 905

  Fly   753 GI-AGSDVSKQAADMILLD-------DNFASIVTGVE-EGRLIFDNLKKSIAYTLTSNIPEISPF 808
            || |.|..:||.:.:...:       |..:.::..:| |...|......|||...||.:..|...
Human   906 GIRATSRTAKQRSGLPPSEEQPTSQRDRLSQVLRDLEDESTPIVKLGDASIAAPFTSKLSSIQCI 970

  Fly   809 LAFI---LCDIPLPLGTVTILCIDLGTDMVPAISLAYEHA 845
            ...|   .|.:...|....||.::       |:.|||..:
Human   971 CHVIKQGRCTLVTTLQMFKILALN-------ALILAYSQS 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AtpalphaNP_732572.1 ATPase-IIC_X-K 45..1041 CDD:273445 191/948 (20%)
Cation_ATPase_N 58..132 CDD:214842 16/94 (17%)
E1-E2_ATPase 152..383 CDD:278548 48/282 (17%)
Cation_ATPase 445..539 CDD:289987 26/107 (24%)
COG4087 <695..770 CDD:226572 30/101 (30%)
Cation_ATPase_C 817..1025 CDD:279079 7/28 (25%)
ATP13A1NP_065143.2 P-ATPase-V 85..1173 CDD:273738 191/949 (20%)
A-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986 199..230 3/30 (10%)
A-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986 295..435 31/154 (20%)
E1-E2_ATPase 298..510 CDD:278548 43/226 (19%)
P-domain, part 1. /evidence=ECO:0000250|UniProtKB:P39986 512..541 10/37 (27%)
N-domain. /evidence=ECO:0000250|UniProtKB:P39986 543..724 43/223 (19%)
Cation_ATPase 584..667 CDD:289987 22/102 (22%)
HAD 643..873 CDD:289480 55/248 (22%)
P-domain, part 2. /evidence=ECO:0000250|UniProtKB:P39986 727..885 42/158 (27%)
COG4087 <831..>884 CDD:226572 22/53 (42%)
Arm-like. /evidence=ECO:0000250|UniProtKB:P39986 886..949 9/62 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 889..933 6/43 (14%)
P-domain, part 3. /evidence=ECO:0000250|UniProtKB:P39986 950..965 5/14 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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