DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and atp2b3b

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_021325490.1	Gene:	atp2b3b / 558525	ZFINID:	ZDB-GENE-080409-2	Length:	1297	Species:	Danio rerio

Alignment Length:	1025	Identity:	296/1025 - (28%)
Similarity:	466/1025 - (45%)	Gaps:	270/1025 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NLDDLKQELDI----DFHKISP-----EELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQT 104
            :||:|:..:::    ...||..     |.|.||.::...:|||          |.|..|...:||
Zfish    37 SLDELRNLMELRGAEALQKIQESFTDVEGLCQRLKSSTTDGLS----------DNPTDLEKRRQT 91

  Fly   105 PEWVKFCKNLF-----GGFAMLLW------------IGAILCFVAYSIQASTSEEPADDNLYLG- 151
                 |.:|..     ..|..|:|            :.||:     |:..|..:.|.:|:...|
Zfish    92 -----FGQNFIPPKKPKTFLQLVWEALQDVTLIILELAAII-----SLALSFYQPPGEDSEVCGK 146

  Fly   152 --------------------IVLS--AVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGE 194
                                |:||  .||:||. |:.:.:.|..:.::|...:..:|| |:|.|.
Zfish   147 GAGGAEDEGEAEAGWIEGAAILLSVICVVLVTA-FNDWSKEKQFRGLQSRIELEQRFA-VVRNGN 209

  Fly   195 KLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKN 259
            .:.:...::|:||:.:||:||.:|||..:::..:.|:|.|||||||:...:..|   ::|
Zfish   210 VIQIPVAEMVVGDMAQVKYGDLLPADGVLVQGNDLKIDESSLTGESDHVRKSVE---KDP----- 266

  Fly   260 LAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGE------------------------- 299
            :....|:.:||:.:.:|.:.|.::..|.|..|. |...||
Zfish   267 MLLSGTHVMEGSGRMLVTAVGVNSQSGIIFTLL-GAGEGEEEKKEKKGKQPEAAVETNQNKAKKQ 330

  Fly   300 -----------------------------------------TPIAKEIHHFIHLITGVAVFLGVT 323
                                                     |.:|.:|.....:::.:.|.:.|.
Zfish   331 DGAVAMEMQPLKSAEGGEVEEREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVL 395

  Fly   324 FFVI-AFILG-YHWLD----------AVIFLIG--IIVANVPEGLLATVTVCLTLTAKRMASKNC 374
            :||| .|::| ..||.          ...|:||  ::|..|||||...||:.|..:.|:|...|.
Zfish   396 YFVIDTFVVGNMTWLPECTPIYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNN 460

  Fly   375 LVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKAL 439
            ||::|:|.||:|:.:.||||||||||.|||||...:.::|...  ...|.|.:..:.......|:
Zfish   461 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYINDQHFR--EIPDPSQISPNTLEMIVNAI 523

  Fly   440 SRIATLCNR---AEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKR--NKKIAEV- 498
            |......::   .:.:||      |.|:| |:.:|..||..:.....|...:|::  .:|:.:|
Zfish   524 SINCAYTSKIMPPDVEGG------LPKQV-GNKTECGLLGFLLDLKRDYAPVREQIPEEKLYKVY 581

  Fly   499 PFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIF-INGKEKVL-----DEEMKEAFN 557
            .|||..|...::.:..|.:   :.|..|||.|.:|::||:|. .||:.:..     ||.:|:...
Zfish   582 TFNSVRKSMSTVVQMPDGS---FRLYSKGASEIVLKKCSSILGTNGEARNFRPRDRDEMVKKVIE 643

  Fly   558 NAYMELGGLGERVLGFCDFMLPSDKYP---NGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPD 619
            .  |...||....:|:.|  ||.|..|   |..:..||        |..:.::.:.||.|..|||
Zfish   644 P--MACEGLRTICIGYRD--LPGDPEPEWENEAEIVTD--------LTCIAVVGIEDPVRPEVPD 696

  Fly   620 AVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV----EDIAQRLNIPVSEVNPREAKA 680
            |:.||:.|||.|.|||||:..||:|||...|||..|::.:    :|..:|:         |..|.
Zfish   697 AIRKCQRAGITVRMVTGDNINTARAIASKCGIIQPGDDFLCLEGKDFNRRI---------RNEKG 752

  Fly   681 AVVHGAELRDVSSDQLDEI---LRYHTEIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGD 735
                     ::..:::|:|   ||     |.||:||..|..:|:|.       ||.  :||||||
Zfish   753 ---------EIEQERIDKIWPKLR-----VLARSSPTDKHTLVKGIIDSTVLEQRQ--VVAVTGD 801

  Fly   736 GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 800
            |.||.|||||||:|.||||||:||:|:|:|:||.||||:|||..|..||.::|::.|.:.:.||.
Zfish   802 GTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTV 866

  Fly   801 NIPEISPFLAF----ILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP------R 855
            |:  ::..:||    |..|.||.  .|.:|.::|..|...:::||.|         ||      |
Zfish   867 NV--VAVIVAFTGACITQDSPLK--AVQMLWVNLIMDTFASLALATE---------PPTEALLLR 918

  Fly   856 DPFNDKLVNSRLISMAYGQIGMIQAAAGFFVY-FVIMAENGFLPKKLFGI 904
            .|:..   |:.|||:.     |::...|..|| .||:....|:.:|:|.|
Zfish   919 KPYGR---NNPLISLT-----MMKNILGHGVYQLVIIFTLLFVGEKIFNI 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	296/1025 (29%)
		Cation_ATPase_N	58..132	CDD:214842	21/99 (21%)
		E1-E2_ATPase	152..383	CDD:278548	78/312 (25%)
		Cation_ATPase	445..539	CDD:289987	26/99 (26%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	27/95 (28%)
atp2b3b	XP_021325490.1	E1-E2_ATPase	27..1068	CDD:332568	296/1025 (29%)
atp2b3b	XP_021325490.1	ATP_Ca_trans_C	1107..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010