DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP7B

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_000044.2	Gene:	ATP7B / 540	HGNCID:	870	Length:	1465	Species:	Homo sapiens

Alignment Length:	943	Identity:	198/943 - (20%)
Similarity:	336/943 - (35%)	Gaps:	282/943 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ISPEELYQRFQTHPENGLSHAKAKENLERDGPNA--LTPPKQTPEWVK--FCKNLFG-------- 116
            |.|.::.:..:   |.|...:.|:.|     |||  |....:..:|.|  .|..:||
Human   613 IGPRDIIKIIE---EIGFHASLAQRN-----PNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMI 669

  Fly   117 ---------------------GFAMLLWIGAILC-FVA------YSIQASTSEEPADDNLYLGIV 153
                                 |.::|..|..||| ||.      :.:||..|......|:.:.||
Human   670 YMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIV 734

  Fly   154 L--------SAVVIVTGI---------------------------FSYYQESKSSKIMESFKNMV 183
            |        |.|::|..:                           ..:..:||:|:.:....::.
Human   735 LATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQ 799

  Fly   184 PQFATVIREGE-KLTLRAEDLVL-----GDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEP 242
            ...|||:..|| .|.:|.|.:.:     ||:|:|..|.:.|.|.:::|. |...|.|.:|||:.|
Human   800 ATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEG-NTMADESLITGEAMP 863

  Fly   243 QSRGAEFTHENPLETKNLAFFSTNAVEGT--AKGVVI----SCGDHTVMGRIAGLASGLDTGETP 301
            .::       .|         .:..:.|:  |.|.|:    ..|:.|.:.:|..|.......:.|
Human   864 VTK-------KP---------GSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAP 912

  Fly   302 IAKEIHHFIHLITGVAVFLGVTFFVIAFILGY---------------HWLDAVIFL-------IG 344
            |.:....|........:.:.....|:..::|:               |.....:.:       |.
Human   913 IQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSIT 977

  Fly   345 IIVANVPEGL-LATVTVCLTLTAKRMASKN-CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVA 407
            ::....|..| |||.|..:..|.  :|::| .|:|..:.:|......|:..|||||:|.....|.
Human   978 VLCIACPCSLGLATPTAVMVGTG--VAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVM 1040

  Fly   408 HMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEA 472
            .:     ::..|..          |.|..|.|:.:.|....:|...|.......|:|:..:
Human  1041 RV-----LLLGDVA----------TLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTE---- 1086

  Fly   473 ALLKCMEL----------ALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKG 527
            .|..|.:.          .:.:|..|...:::....|.:..|  :......|....|:...|:.|
Human  1087 TLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLN--EAGSLPAEKDAVPQTFSVLIG 1149

  Fly   528 APERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTD 592
            ..|.:.....||..:..:.:.|.|||             |:..
Human  1150 NREWLRRNGLTISSDVSDAMTDHEMK-------------GQTA---------------------- 1179

  Fly   593 DINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNE 657
             |...||.: ..|::::.|..:.....||...:|.|:.|:::|||:..||:|||..|||    |:
Human  1180 -ILVAIDGV-LCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGI----NK 1238

  Fly   658 TVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEG 722
                                                             |||...|..|:..|:.
Human  1239 -------------------------------------------------VFAEVLPSHKVAKVQE 1254

  Fly   723 CQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEG---- 783
            .|..|..||:.||||||||||.:||:|||:| .|:||:.:|||::|:.::...:|..:...
Human  1255 LQNKGKKVAMVGDGVNDSPALAQADMGVAIG-TGTDVAIEAADVVLIRNDLLDVVASIHLSKRTV 1318

  Fly   784 RLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEAD 848
            |.|..||..::.|.|. .||        |...:.:|:|.|....:........::|:.....:..
Human  1319 RRIRINLVLALIYNLV-GIP--------IAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLK 1374

  Fly   849 IMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAA 881
            ..|:|..:         |..:.|:|.:..:.|:
Human  1375 CYKKPDLE---------RYEAQAHGHMKPLTAS 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	198/943 (21%)
		Cation_ATPase_N	58..132	CDD:214842	22/101 (22%)
		E1-E2_ATPase	152..383	CDD:278548	59/301 (20%)
		Cation_ATPase	445..539	CDD:289987	15/103 (15%)
		COG4087	<695..770	CDD:226572	33/74 (45%)
		Cation_ATPase_C	817..1025	CDD:279079	10/65 (15%)
ATP7B	NP_000044.2	E1-E2_ATPase	769..1016	CDD:278548	53/265 (20%)
		COG4087	<1206..1309	CDD:226572	49/156 (31%)
		HMA	61..124	CDD:238219
		HMA	146..209	CDD:238219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..249
		HMA	260..318	CDD:238219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..355
		HMA	363..425	CDD:238219
		HMA	492..554	CDD:238219
		ZntA	566..1355	CDD:225127	191/889 (21%)
		HMA	567..630	CDD:238219	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910