DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP7A

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens

Alignment Length:	810	Identity:	173/810 - (21%)
Similarity:	307/810 - (37%)	Gaps:	227/810 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 KNLFGGFAMLLWIGAILCFVA-------YSIQASTSEEPADDNLYLGIVLSAVV-----IVTGIF 164
            :.:..|.:::..:..:||...       :.|||..:.:....|:.:.|||:..:     ::..:.
Human   703 RQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLV 767

  Fly   165 SYYQESK---------------------------SSKIMESFKNMVPQFATVIREGEKLTLRAED 202
            :.|:.:|                           ..|..|:...::...||   |...:||.:::
Human   768 AMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQAT---EATIVTLDSDN 829

  Fly   203 LVL------------GDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPL 255
            ::|            ||:::|..|.:.|.|.|:||..:. ||.|.:|||:.|.::       .|.
Human   830 ILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAK-------KPG 886

  Fly   256 ETKNLAFFSTNAVEGTAKGVVISCGDH----TVMGRIAGLASGLDTGETPIA----KEIHHFIHL 312
            .|......:.|       |.::.|..|    |.:.:|..|.....|.:.||.    |...:|:..
Human   887 STVIAGSINQN-------GSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPF 944

  Fly   313 ITGVAVFLGVTFFVIAFI---------LGYH----WLDAVI---FLIGIIVANV--PEGL-LATV 358
            |..|::...:.:.||.|:         .||:    ..:.:|   |...|.|..:  |..| |||.
Human   945 IVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATP 1009

  Fly   359 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTED 423
            |..:..|... |....|:|..|.:|.......:..|||||:|.....|      ||:   ....:
Human  1010 TAVMVGTGVG-AQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVV------NQV---KVLTE 1064

  Fly   424 QSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELAL------ 482
            .:.:.:      .|.|:.:.|..:.:|...|.......|:|:..:    .|..|::..:
Human  1065 SNRISH------HKILAIVGTAESNSEHPLGTAITKYCKQELDTE----TLGTCIDFQVVPGCGI 1119

  Fly   483 -GDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEK 546
             ..|.||.....|         |.:.:     ||.|.....||...|..   |:.||    ....
Human  1120 SCKVTNIEGLLHK---------NNWNI-----EDNNIKNASLVQIDASN---EQSST----SSSM 1163

  Fly   547 VLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLR--------- 602
            ::|.::..|.|....::      ::|..::|:     .||...|.|..:|..::.|
Human  1164 IIDAQISNALNAQQYKV------LIGNREWMI-----RNGLVINNDVNDFMTEHERKGRTAVLVA 1217

  Fly   603 ----FVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIA 663
                ..||:::.|..:.....|:...:|.|::|:::|||:..||::||..|||..
Human  1218 VDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK---------- 1272

  Fly   664 QRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGA 728
                                                       |||...|..|:..|:..|..|.
Human  1273 -------------------------------------------VFAEVLPSHKVAKVKQLQEEGK 1294

  Fly   729 IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS 793
            .||:.|||:||||||..|::|:|:| .|:||:.:|||::|:.::...:|..::..|.....::.:
Human  1295 RVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRIN 1358

  Fly   794 IAYTLTSNIPEISPFLAFILCDIPLPLGTV 823
            ..:.|..|:..| |..|.:.    :|:|.|
Human  1359 FVFALIYNLVGI-PIAAGVF----MPIGLV 1383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	173/810 (21%)
		Cation_ATPase_N	58..132	CDD:214842	3/19 (16%)
		E1-E2_ATPase	152..383	CDD:278548	65/301 (22%)
		Cation_ATPase	445..539	CDD:289987	19/100 (19%)
		COG4087	<695..770	CDD:226572	30/74 (41%)
		Cation_ATPase_C	817..1025	CDD:279079	3/7 (43%)
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	173/810 (21%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1487..1488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910