Protein Alignment Atpalpha and Atp2a3

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_058025.2
• Gene: Atp2a3 / 53313
• MGIID: 1194503
• Length: 1038
• Species: Mus musculus
• Alignment Length: 1064
• Identity: 321/1064 - (30%)
• Similarity: 500/1064 - (46%)
• Gaps: 173/1064 - (16%)

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGA 126
            |.:|..::.:||....|.|||..:..:..||.|||.|...:....|....:........:|.:.|
Mouse     5 HLLSAADVLRRFSVTAEGGLSLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAA 69

  Fly   127 ILCFVAYSIQ-----ASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQF 186
            ::.||....:     .:...||        :|:..:::...|...:||..:...:|:.|...|:.
Mouse    70 LVSFVLAWFEEGEETTTAFVEP--------LVIMLILVANAIVGVWQERNAESAIEALKEYEPEM 126

  Fly   187 ATVIREGEK--LTLRAEDLVLGDVVEVKFGDRIPADIRIIEARN--FKVDNSSLTGESEPQSRGA 247
            ..|||...|  ..:||.|:|.||:|||..||::|||:|:||.::  .:||.|.|||||...::
Mouse   127 GKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTK-- 189

  Fly   248 EFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAK 304
               |.:.:        :.||:.|..||...|.|.||.::.|..|.:|:|....:.::...||:.:
Mouse   190 ---HTDAIPDPRAVNQDKKNMLFSGTNIASGKALGVAVATGLQTELGKIRSQMAAVEPERTPLQR 251

  Fly   305 EIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATVT 359
            ::..|...::.....:.|..:||..      ..|..||...::    .:.:.||.:||||.|.:|
Mouse   252 KLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVIT 316

  Fly   360 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEAD----- 419
            .||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:.   :.||:
Mouse   317 TCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEAEAGTCR 378

  Fly   420 --------TTEDQSGV-----------QYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPI 460
                    ||....|.           |:|    |...|:.|..|||.:     |.||..:.|
Mouse   379 LHEFTISGTTYTPEGEVRQGEQPVRCGQFD----GLVELATICALCNDSALDYNEAKGVYEKV-- 437

  Fly   461 LKKEVSGDASEAALLKCMELALGDVMN---------------------IRKRNKKIAEVPFNSTN 504
                  |:|:|.||     ..|.:.||                     |::..:|...:.| |.:
Mouse   438 ------GEATETAL-----TCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEF-SRD 490

  Fly   505 KYQVSIHETEDTNDPRY---LLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGL 566
            :..:|::.|....||:.   .:.:|||||.::||||::.:..:...|....:|.. .|.:...|.
Mouse   491 RKSMSVYCTPTRADPKVQGSKMFVKGAPESVIERCSSVRVGSRTAPLSTTSREHI-LAKIRDWGS 554

  Fly   567 GERVLGFCDFMLPSDKYPNGFKFNTDD----INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSA 627
            |...|. |..:...|..|.....:.||    :.:..| |.|||.:.|:||||..|...:.:|..|
Mouse   555 GSDTLR-CLALATRDTPPRKEDMHLDDCSRFVQYETD-LTFVGCVGMLDPPRPEVAACITRCSRA 617

  Fly   628 GIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVS 692
            ||:|:|:|||:..||.||.:.:||..:    .||:.              .||..  |.|..|:|
Mouse   618 GIRVVMITGDNKGTAVAICRRLGIFGD----TEDVL--------------GKAYT--GREFDDLS 662

  Fly   693 SDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 757
            .:|..:..|  |...|||..|..|..|||..|....|.|:|||||||:||||||:||:||| :|:
Mouse   663 PEQQRQACR--TARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGT 724

  Fly   758 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGT 822
            .|:|.||:|:|.||||||||..|||||.|::|:|:.|.|.::||:.|:.......:..:|..|..
Mouse   725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789

  Fly   823 VTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGM------IQAA 881
            |.:|.::|.||.:||.:|.:...:.|||::|||:| .:.|::..|. ..|..||:      :.||
Mouse   790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRNP-REALISGWLF-FRYLAIGVYVGLATVAAA 852

  Fly   882 AGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVV 946
            ..:|:|.....:..|     :.:|........|.|       :...|.|..|....|...:|::|
Mouse   853 TWWFLYDTEGPQVTF-----YQLRNFLKCSEDNPL-------FAGIDCKVFESRFPTTMALSVLV 905

  Fly   947 -VQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSY----CPGMEKGLRMYPLKLVWW 1006
             ::..:.:...:...|:.:  |..| ||..|:...|::..|.:    .|.:....::.||....|
Mouse   906 TIEMCNALNSVSENQSLLR--MPPW-LNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQW 967

  Fly  1007 FPAIPFALAIFIYDETRRFYLRRN 1030
            ...:..:|.:.:.||..: ||.||
Mouse   968 GVVLQMSLPVILLDEALK-YLSRN 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	321/1064 (30%)
		Cation_ATPase_N	58..132	CDD:214842	18/69 (26%)
		E1-E2_ATPase	152..383	CDD:278548	77/252 (31%)
		Cation_ATPase	445..539	CDD:289987	32/122 (26%)
		COG4087	<695..770	CDD:226572	39/74 (53%)
		Cation_ATPase_C	817..1025	CDD:279079	51/218 (23%)
Atp2a3	NP_058025.2	Cation_ATPase_N	4..72	CDD:279080	17/66 (26%)
		ATPase-IIA1_Ca	53..989	CDD:273452	304/1013 (30%)
		E1-E2_ATPase	92..340	CDD:278548	77/252 (31%)
		Interaction with phospholamban 1. /evidence=ECO:0000250|UniProtKB:P04191	370..400		5/29 (17%)
		Cation_ATPase	419..528	CDD:289987	32/122 (26%)
		HAD	<604..712	CDD:289480	48/129 (37%)
		Cation_ATPase_C	784..987	CDD:279079	51/220 (23%)
		Interaction with phospholamban 2. /evidence=ECO:0000250|UniProtKB:P04191	788..808		7/19 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920