DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP2B4

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001675.3	Gene:	ATP2B4 / 493	HGNCID:	817	Length:	1205	Species:	Homo sapiens

Alignment Length:	1032	Identity:	297/1032 - (28%)
Similarity:	460/1032 - (44%)	Gaps:	250/1032 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERD--GPNALTPPKQTP 105
            |:.:..:.|.|.|   |:.|....:.|..|.:|.|..|||...|.....|.  |.|.: |||:..
Human    31 KLMELRSRDALTQ---INVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVI-PPKKPK 91

  Fly   106 EWVKFC-KNLFGGFAMLLWIGAILCFVAYSIQASTSEE----------PADDN------LYLGIV 153
            .:::.. :.|.....::|.|.||:..| .|......||          |.|:|      :....:
Human    92 TFLELVWEALQDVTLIILEIAAIISLV-LSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAI 155

  Fly   154 LSAVVIVTGIFSYYQESKSSKIMESFKNM-----VPQFATVIREGEKLTLRAEDLVLGDVVEVKF 213
            |.:|:||..:.::...||.    :.|:.:     ..|..::||.|:.:.|...::|:||:.:||:
Human   156 LFSVIIVVLVTAFNDWSKE----KQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKY 216

  Fly   214 GDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVIS 278
            ||.:|||..:|:..:.|:|.|||||||:...:.        |:...:....|:.:||:.:.||.:
Human   217 GDLLPADGILIQGNDLKIDESSLTGESDHVKKS--------LDKDPMLLSGTHVMEGSGRMVVTA 273

  Fly   279 CGDHTVMGRIA---------------------------------GLA---------SGLDTGE-- 299
            .|.::..|.|.                                 |:|         .|:|..|
Human   274 VGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKD 338

  Fly   300 ------------------TPIAKEIHHFIHLITGVAVFLGVTFFVI-AFILGYH-WLD------- 337
                              |.:|.:|.....|::.:.||:.:.:||| .|::... ||.
Human   339 KKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYI 403

  Fly   338 ---AVIFLIGI--IVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTG 397
               ...|:|||  :|..|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.|||||||
Human   404 QYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 468

  Fly   398 TLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDR-TSP-------------GFKALSRIATLCNR 448
            |||.|||||...:.             .|:.|.: .||             |....|...:....
Human   469 TLTMNRMTVVQAYI-------------GGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILP 520

  Fly   449 AEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIA-EVP---------FNST 503
            .|.:||      |.::| |:.:|.||       ||.|.::::..:.:. |||         |||.
Human   521 PEKEGG------LPRQV-GNKTECAL-------LGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSV 571

  Fly   504 NKYQVSIHETEDTNDPR--YLLVMKGAPERILERCSTIF------INGKEKVLDEEMKEAFNNAY 560
            .|...::     ..:|.  :.:..|||.|.||.:|:.|.      :..|.|..|:.::.....
Human   572 RKSMSTV-----IRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEP-- 629

  Fly   561 MELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCR 625
            |...||....:.:.||   .|..|     :.|:.|..:..|..:.::.:.||.|..||||:|||:
Human   630 MACDGLRTICIAYRDF---DDTEP-----SWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCK 686

  Fly   626 SAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNP--REAKAAVVHGAEL 688
            .|||.|.|||||:..||:|||...||::.|::.       |.:...|.|.  |..|.
Human   687 QAGITVRMVTGDNINTARAIATKCGILTPGDDF-------LCLEGKEFNRLIRNEKG-------- 736

  Fly   689 RDVSSDQLDEI---LRYHTEIVFARTSPQQKLIIVEGC--QRMG---AIVAVTGDGVNDSPALKK 745
             :|..::||:|   ||     |.||:||..|..:|:|.  ..:|   .:|||||||.||.|||||
Human   737 -EVEQEKLDKIWPKLR-----VLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKK 795

  Fly   746 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLA 810
            ||:|.||||||:||:|:|:|:||.||||.|||..|..||.::|::.|.:.:.||.|:  ::..:|
Human   796 ADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVA 858

  Fly   811 F----ILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLI 868
            |    |..|.||.  .|.:|.::|..|...:::||.|.....::||.|   ..|...:.:...::
Human   859 FTGACITQDSPLK--AVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNIL 921

  Fly   869 SMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWT 925
            ..|:.|:         .|.|:::    |..:|.|.|    ||.....|.....|.:|
Human   922 GHAFYQL---------IVIFILV----FAGEKFFDI----DSGRKAPLHSPPSQHYT 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	296/1030 (29%)
		Cation_ATPase_N	58..132	CDD:214842	21/76 (28%)
		E1-E2_ATPase	152..383	CDD:278548	78/311 (25%)
		Cation_ATPase	445..539	CDD:289987	27/105 (26%)
		COG4087	<695..770	CDD:226572	44/82 (54%)
		Cation_ATPase_C	817..1025	CDD:279079	26/112 (23%)
ATP2B4	NP_001675.3	ATPase-IIB_Ca	20..1052	CDD:273668	297/1032 (29%)
ATP2B4	NP_001675.3	ATP_Ca_trans_C	1089..1135	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920