Protein Alignment Atpalpha and ATP2B3

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: XP_016885042.1
• Gene: ATP2B3 / 492
• HGNCID: 816
• Length: 1274
• Species: Homo sapiens
• Alignment Length: 1081
• Identity: 299/1081 - (27%)
• Similarity: 465/1081 - (43%)
• Gaps: 293/1081 - (27%)

  Fly    67 EELY-------QRFQTHPENGLSHAKAKENLERD----GPNALTPPKQTPEWVKFCKNLFGGFAM 120
            ||.|       :|.:|.|..||  |....:||:.    |.|.: ||||...:::..........:
Human    50 EEAYGDVSGLCRRLKTSPTEGL--ADNTNDLEKRRQIYGQNFI-PPKQPKTFLQLVWEALQDVTL 111

  Fly   121 LLWIGAILCFVAYSIQASTSEEP---------ADDN------------LYLGIVLSAVVIVTGIF 164
            ::...|.:..:..|..|...||.         |:|.            :.|.::  .||:||. |
Human   112 IILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVI--CVVLVTA-F 173

  Fly   165 SYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNF 229
            :.:.:.|..:.::|......:| ||||.|:.|.:....||:||:.:||:||.:|||..:|:|.:.
Human   174 NDWSKEKQFRGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDL 237

  Fly   230 KVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGL--- 291
            |:|.|||||||:...:.|:   ::|     :....|:.:||:.:.||.:.|.::..|.|..|
Human   238 KIDESSLTGESDHVRKSAD---KDP-----MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGA 294

  Fly   292 -----------------------ASGLDTGE---------------------------------- 299
                                   ..|.|.|.
Human   295 GGEEEEKKDKKGKQQDGAMESSQTKGTDLGHGVPLCAAKKQDGAVAMEMQPLKSAEGGEMEEREK 359

  Fly   300 -----------------TPIAKEIHHFIHLITGVAVFLGVTFFVI-AFIL-GYHWLD-------- 337
                             |.:|.:|.....:::.:.|.:.|.:||| .|:: |..||.
Human   360 KKANAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQ 424

  Fly   338 --AVIFLIG--IIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGT 398
              ...|:||  ::|..|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||
Human   425 YFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGT 489

  Fly   399 LTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALS-RIATLCNRAEFKGGQDGVPILK 462
            ||.|||||...:.              |..:.:..|...||: :|..|...|..........||.
Human   490 LTTNRMTVVQSYL--------------GDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILP 540

  Fly   463 KEVS-------GDASEAALLKCMELALGDVMNIRKRNKKIAE-VP---------FNSTNKYQVSI 510
            .|..       |:.:|.||       ||.|:::::..:.:.| :|         |||..|...::
Human   541 PEKEGALPRQVGNKTECAL-------LGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSMSTV 598

  Fly   511 HETEDTNDPRYLLVMKGAPERILERCSTIF-ING-----KEKVLDEEMKEAFNNAYMELGGLGER 569
            ....|..   :.|..|||.|.:|::|:.|. .||     :.:..|:.:::....  |...||...
Human   599 IRMPDGG---FRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEP--MACDGLRTI 658

  Fly   570 VLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMV 634
            .:.:.||..       |.:.:.|:.|..:.:|..:.::.:.||.|..||:|:.||:.|||.|.||
Human   659 CIAYRDFSA-------GQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMV 716

  Fly   635 TGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI 699
            |||:..||:|||...|||..|    ||.   |.:...|.|.|...       |..::..::||::
Human   717 TGDNINTARAIAAKCGIIQPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERLDKV 767

  Fly   700 ---LRYHTEIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGI 754
               ||     |.||:||..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||
Human   768 WPKLR-----VLARSSPTDKHTLVKGIIDSTTGEQRQ--VVAVTGDGTNDGPALKKADVGFAMGI 825

  Fly   755 AGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCD 815
            ||:||:|:|:|:||.||||.|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|
Human   826 AGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQD 888

  Fly   816 IPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP--RD-PFNDKLVNSRLISMAYGQIGM 877
            .||.  .|.:|.::|..|...:::||.|.....::.|.|  || |...:.:...::..|..|:.:
Human   889 SPLK--AVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAI 951

  Fly   878 IQAAAGFFVYFV------------------------------IMAE--NGFLPKKLFGIRKMWDS 910
            |     |.:.||                              :|.:  |....:|:.|.|.::|.
Human   952 I-----FTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDG 1011

  Fly   911 KAVNDL--TDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQW 949
            ...|.:  |...|                 .|.|.||:||:
Human  1012 IFSNPIFCTIVLG-----------------TFGIQIVIVQF 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	299/1081 (28%)
		Cation_ATPase_N	58..132	CDD:214842	18/75 (24%)
		E1-E2_ATPase	152..383	CDD:278548	81/321 (25%)
		Cation_ATPase	445..539	CDD:289987	26/110 (24%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	35/170 (21%)
ATP2B3	XP_016885042.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920