Protein Alignment Atpalpha and ATP2B2

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: XP_016861981.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1272
• Species: Homo sapiens
• Alignment Length: 1170
• Identity: 307/1170 - (26%)
• Similarity: 489/1170 - (41%)
• Gaps: 349/1170 - (29%)

  Fly    38 RKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERD----GPNAL 98
            |...|.|..||...|             .|.:.:|.:|.|..||  .....:||:.    |.|.:
Human    38 RGTEAVVKIKETYGD-------------TEAICRRLKTSPVEGL--PGTAPDLEKRKQIFGQNFI 87

  Fly    99 TPPKQTPEWVKFCKNLFGGFAMLLW-----IGAILCFVAYSIQ---------------ASTSEEP 143
             |||:...           |..|:|     :..|:..:|..|.               .:|::..
Human    88 -PPKKPKT-----------FLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGG 140

  Fly   144 ADDN------------LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKL 196
            |:|.            :.|.::  .||:||. |:.:.:.|..:.::|......:| ||:|.|:.:
Human   141 AEDEGEAEAGWIEGAAILLSVI--CVVLVTA-FNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVV 201

  Fly   197 TLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLA 261
            .:...::|:||:.:||:||.:|||...|:..:.|:|.|||||||:...:..:   ::|     :.
Human   202 QIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDP-----ML 258

  Fly   262 FFSTNAVEGTAKGVVISCGDHTVMGRI-------------------------------------- 288
            ...|:.:||:.:.:|.:.|.::..|.|
Human   259 LSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNA 323

  Fly   289 -----AGLASG---------------------------LDTGE---------------------- 299
                 |.|.:|                           |.:.|
Human   324 ADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQG 388

  Fly   300 --TPIAKEIHHFIHLITGVAVFLGVTFFVI-AFILGYH-WLD----------AVIFLIG--IIVA 348
              |.:|.:|.....:::.:.|.:.|.:|.: .|::... ||.          ...|:||  ::|.
Human   389 KLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVV 453

  Fly   349 NVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDN 413
            .|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||...:..:
Human   454 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGD 518

  Fly   414 QIIEADTTEDQSGVQY----DRTSPGFKALSRI--ATLCNRA--------EFKGGQDGVPILKKE 464
                         |.|    |.:|...|.:..:  |...|.|        |.:|.      |.::
Human   519 -------------VHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA------LPRQ 564

  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKI-AEVP---------FNSTNKYQVSIHETEDTNDP 519
            | |:.:|..|       ||.|:::::..:.: :::|         |||..|...::.:..|.:
Human   565 V-GNKTECGL-------LGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDES-- 619

  Fly   520 RYLLVMKGAPERILERCSTIFING-------KEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFM 577
             :.:..|||.|.:|::|..| :||       :.:..||.:|:....  |...||....:.:.||
Human   620 -FRMYSKGASEIVLKKCCKI-LNGAGEPRVFRPRDRDEMVKKVIEP--MACDGLRTICVAYRDF- 679

  Fly   578 LPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITA 642
             ||...|     :.|:.|..::.|..:.::.:.||.|..||:|:.||:.|||.|.|||||:..||
Human   680 -PSSPEP-----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 738

  Fly   643 KAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---LRYHT 704
            :|||...|||..|    ||.   |.:...|.|.|...       |..::..:::|:|   ||
Human   739 RAIAIKCGIIHPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERIDKIWPKLR--- 786

  Fly   705 EIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQ 762
              |.||:||..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||||:||:|:
Human   787 --VLARSSPTDKHTLVKGIIDSTHTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 847

  Fly   763 AADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPLPLGTV 823
            |:|:||.||||:|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||.  .|
Human   848 ASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPLK--AV 908

  Fly   824 TILCIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLISMAYGQIGMI------- 878
            .:|.::|..|...:::||.|.....::.|.|   ..|...:.:...::..|..|:.:|
Human   909 QMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVG 973

  Fly   879 ----QAAAG---------------FFVYFVIM-AENGFLPKKLFGIRKMWDSKAVNDL--TDSYG 921
                |..:|               .|..||:| ..|....:|:.|.|.::|....|.:  |...|
Human   974 EKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLG 1038

  Fly   922 QEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFG---LVFETVLA 983
                             .|.|.||:||:..    |....|..|.....|.:..|   ||:..|:|
Human  1039 -----------------TFAIQIVIVQFGG----KPFSCSPLQLDQWMWCIFIGLGELVWGQVIA 1082

  Fly   984  983
            Human  1083  1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	304/1163 (26%)
		Cation_ATPase_N	58..132	CDD:214842	17/82 (21%)
		E1-E2_ATPase	152..383	CDD:278548	73/338 (22%)
		Cation_ATPase	445..539	CDD:289987	24/111 (22%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	44/202 (22%)
ATP2B2	XP_016861981.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920