Protein Alignment Atpalpha and ATP2B1

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001353453.1
• Gene: ATP2B1 / 490
• HGNCID: 814
• Length: 1249
• Species: Homo sapiens
• Alignment Length: 1098
• Identity: 304/1098 - (27%)
• Similarity: 472/1098 - (42%)
• Gaps: 293/1098 - (26%)

  Fly    72 RFQTHPENGLSHAKAKENLERD----GPNALTPPKQTPEWVKFCKNLFGGFAMLLW-----IGAI 127
            :.:|.|..|||...|  :|||.    |.|.: |||:...           |..|:|     :..|
Human    62 KLKTSPNEGLSGNPA--DLERREAVFGKNFI-PPKKPKT-----------FLQLVWEALQDVTLI 112

  Fly   128 LCFVA--YSIQASTSEEPADDNLYLG--------------------IVLSAV-VIVTGIFSYYQE 169
            :..:|  .|:..|..:.|..||...|                    |:||.| |::...|:.:.:
Human   113 ILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSK 177

  Fly   170 SKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNS 234
            .|..:.::|......:| ||||.|:.:.:...|:.:||:.:||:||.:|||..:|:..:.|:|.|
Human   178 EKQFRGLQSRIEQEQKF-TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDES 241

  Fly   235 SLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGL-------- 291
            ||||||:...:.        |:...|....|:.:||:.:.||.:.|.::..|.|..|
Human   242 SLTGESDHVKKS--------LDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEE 298

  Fly   292 ----------------------------------------ASGLDTGE----------------- 299
                                                    ..|.|..|
Human   299 EKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQ 363

  Fly   300 ---TPIAKEIHHFIHLITGVAVFLGVTFFVI--AFILGYHWLD----------AVIFLIG--IIV 347
               |.:|.:|.....|::.:.|.:.|.:|||  .::....||.          ...|:||  ::|
Human   364 GKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLV 428

  Fly   348 ANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFD 412
            ..|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||...:.:
Human   429 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIN 493

  Fly   413 NQIIEADTTEDQSGVQYDRTSPGFKAL---------SRIATLCNRA------EFKGGQDGVPILK 462
            .:             .|.:. |..:|:         :.|:..|...      |.:||      |.
Human   494 EK-------------HYKKV-PEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGG------LP 538

  Fly   463 KEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVP---------FNSTNKYQVSIHETEDTND 518
            :.| |:.:|.|||..:.....|..::|.      |:|         |||..|   |:......:|
Human   539 RHV-GNKTECALLGLLLDLKRDYQDVRN------EIPEEALYKVYTFNSVRK---SMSTVLKNSD 593

  Fly   519 PRYLLVMKGAPERILERCSTIF-INGKEKVL-----DEEMKEAFNNAYMELGGLGERVLGFCDFM 577
            ..|.:..|||.|.||::|..|. .||:.||.     |:.:|........|  ||....|.|.||
Human   594 GSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASE--GLRTICLAFRDF- 655

  Fly   578 LPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITA 642
             |:.: |.....|.:||   :..|..:.::.:.||.|..||||:.||:.|||.|.|||||:..||
Human   656 -PAGE-PEPEWDNENDI---VTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTA 715

  Fly   643 KAIAKSVGIISEGNETV----EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---L 700
            :|||...||:..|.:.:    :|..:|:         |..|.         ::..:::|:|   |
Human   716 RAIATKCGILHPGEDFLCLEGKDFNRRI---------RNEKG---------EIEQERIDKIWPKL 762

  Fly   701 RYHTEIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSD 758
            |     |.||:||..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||||:|
Human   763 R-----VLARSSPTDKHTLVKGIIDSTVSDQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTD 820

  Fly   759 VSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPLP 819
            |:|:|:|:||.||||.|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||.
Human   821 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPLK 883

  Fly   820 LGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLISMAYGQIGMIQAA 881
              .|.:|.::|..|.:.:::||.|.....::.|.|   ..|...:.:...::..|:.|:
Human   884 --AVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQL------ 940

  Fly   882 AGFFVYFVIMAENGFLPKKLFGIRK----------------MWDSKAVNDLTDSYGQEWTYRDRK 930
               .|.|.::    |..:|.|.|..                ::::..:..|.:.......:.:|.
Human   941 ---VVVFTLL----FAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERN 998

  Fly   931 TLEYTCHTAFFISIV----VVQWADLIICK--TRRNSIFQQGMRNWALNFGLVFETVL 982
            ..|...:.|.|.:||    |||   :||.:  .:..|..:..:..|..:..|...|:|
Human   999 VFEGIFNNAIFCTIVLGTFVVQ---IIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLL 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	304/1098 (28%)
		Cation_ATPase_N	58..132	CDD:214842	18/68 (26%)
		E1-E2_ATPase	152..383	CDD:278548	78/313 (25%)
		Cation_ATPase	445..539	CDD:289987	29/108 (27%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	37/191 (19%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	304/1098 (28%)
		ATP_Ca_trans_C	1103..1178	CDD:403580

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920