Protein Alignment Atpalpha and ATP2A2

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_733765.1
• Gene: ATP2A2 / 488
• HGNCID: 812
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 1065
• Identity: 315/1065 - (29%)
• Similarity: 494/1065 - (46%)
• Gaps: 169/1065 - (15%)

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAM-LLWIG 125
            |..:.||:...|..:...|||..:.|:..||.|.|.| |.::....::.....|....: :|.:.
Human     5 HTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNEL-PAEEGKTLLELVIEQFEDLLVRILLLA 68

  Fly   126 AILCFVAYSIQASTSE-----EPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQ 185
            |.:.||....:.....     ||        .|:..:::...|...:||..:...:|:.|...|:
Human    69 ACISFVLAWFEEGEETITAFVEP--------FVILLILVANAIVGVWQERNAENAIEALKEYEPE 125

  Fly   186 FATVIREGEKLT--LRAEDLVLGDVVEVKFGDRIPADIRI--IEARNFKVDNSSLTGESEPQSRG 246
            ...|.|:..|..  ::|:|:|.||:||:..||::|||||:  |::...:||.|.|||||.
Human   126 MGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESV----- 185

  Fly   247 AEFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIA 303
            :...|.:|:        :.||:.|..||...|.|.|||::.|.:|.:|:|.......:...||:.
Human   186 SVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ 250

  Fly   304 KEIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATV 358
            :::..|...::.|...:.:..::|..      :.|..|:...|:    .:.:.||.:||||.|.:
Human   251 QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVI 315

  Fly   359 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTT-- 421
            |.||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:..:: :|.||.
Human   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDR-VEGDTCSL 379

  Fly   422 -----------------EDQSGV---QYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPIL 461
                             :|...|   |||    |...|:.|..|||.:     |.||..:.|
Human   380 NEFTITGSTYAPIGEVHKDDKPVNCHQYD----GLVELATICALCNDSALDYNEAKGVYEKV--- 437

  Fly   462 KKEVSGDASEAAL------LKCMELALGDVMNIRKRN------KKIAEVPFN---STNKYQVSIH 511
                 |:|:|.||      :...:..|..:..|.:.|      |::.:..|.   |.::..:|::
Human   438 -----GEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVY 497

  Fly   512 ETEDTNDPRYL----LVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGE--RV 570
            .|  .|.|...    :.:|||||.:::||:.|.:...:..:...:|:...:...|.|...:  |.
Human   498 CT--PNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRC 560

  Fly   571 LGFCDFMLP-------SDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAG 628
            |.......|       .:...|..|:.|        ||.|||.:.|:||||..|..:|..||.||
Human   561 LALATHDNPLRREEMHLEDSANFIKYET--------NLTFVGCVGMLDPPRIEVASSVKLCRQAG 617

  Fly   629 IKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQR--LNIPVSEVNPREAKAAVVHGAELRDV 691
            |:|||:|||:..||.||.:.:||..:.    ||:..:  ......|:||
Human   618 IRVIMITGDNKGTAVAICRRIGIFGQD----EDVTSKAFTGREFDELNP---------------- 662

  Fly   692 SSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAG 756
             |.|.|..|...   .|||..|..|..|||..|....|.|:|||||||:||||||:||:||| :|
Human   663 -SAQRDACLNAR---CFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SG 722

  Fly   757 SDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLG 821
            :.|:|.|::|:|.||||::||..|||||.|::|:|:.|.|.::||:.|:...........|..|.
Human   723 TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALI 787

  Fly   822 TVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAA--GF 884
            .|.:|.::|.||.:||.:|.:...:.|||.:|||:| .:.|::..|. ..|..||....||  |.
Human   788 PVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNP-KEPLISGWLF-FRYLAIGCYVGAATVGA 850

  Fly   885 FVYFVIMAENGFLPK-KLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQ 948
            ..::.|.|:.|  |: ..:.:......|  .|..|..|.:....:.   .|....|..: :|.::
Human   851 AAWWFIAADGG--PRVSFYQLSHFLQCK--EDNPDFEGVDCAIFES---PYPMTMALSV-LVTIE 907

  Fly   949 WADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLS----YCPGMEKGLRMYPLKLVWWFPA 1009
            ..:.:...:...|:.:  |..|. |..||....|:..|.    |...:....::.||.:..|...
Human   908 MCNALNSLSENQSLLR--MPPWE-NIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMV 969

  Fly  1010 IPFALAIFIYDETRRFYLRR--NPG 1032
            :..:|.:.:.|||.:|..|.  .||
Human   970 LKISLPVILMDETLKFVARNYLEPG 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	315/1065 (30%)
ATP2A2	NP_733765.1	P-type_ATPase_SERCA	5..988	CDD:319778	312/1057 (30%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:18971376	575..594		6/26 (23%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		7/19 (37%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250|UniProtKB:O55143	788..1042		54/220 (25%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		3/10 (30%)