DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP2A2

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_733765.1	Gene:	ATP2A2 / 488	HGNCID:	812	Length:	1042	Species:	Homo sapiens

Alignment Length:	1065	Identity:	315/1065 - (29%)
Similarity:	494/1065 - (46%)	Gaps:	169/1065 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAM-LLWIG 125
            |..:.||:...|..:...|||..:.|:..||.|.|.| |.::....::.....|....: :|.:.
Human     5 HTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNEL-PAEEGKTLLELVIEQFEDLLVRILLLA 68

  Fly   126 AILCFVAYSIQASTSE-----EPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQ 185
            |.:.||....:.....     ||        .|:..:::...|...:||..:...:|:.|...|:
Human    69 ACISFVLAWFEEGEETITAFVEP--------FVILLILVANAIVGVWQERNAENAIEALKEYEPE 125

  Fly   186 FATVIREGEKLT--LRAEDLVLGDVVEVKFGDRIPADIRI--IEARNFKVDNSSLTGESEPQSRG 246
            ...|.|:..|..  ::|:|:|.||:||:..||::|||||:  |::...:||.|.|||||.
Human   126 MGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESV----- 185

  Fly   247 AEFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIA 303
            :...|.:|:        :.||:.|..||...|.|.|||::.|.:|.:|:|.......:...||:.
Human   186 SVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ 250

  Fly   304 KEIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATV 358
            :::..|...::.|...:.:..::|..      :.|..|:...|:    .:.:.||.:||||.|.:
Human   251 QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVI 315

  Fly   359 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTT-- 421
            |.||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:..:: :|.||.
Human   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDR-VEGDTCSL 379

  Fly   422 -----------------EDQSGV---QYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPIL 461
                             :|...|   |||    |...|:.|..|||.:     |.||..:.|
Human   380 NEFTITGSTYAPIGEVHKDDKPVNCHQYD----GLVELATICALCNDSALDYNEAKGVYEKV--- 437

  Fly   462 KKEVSGDASEAAL------LKCMELALGDVMNIRKRN------KKIAEVPFN---STNKYQVSIH 511
                 |:|:|.||      :...:..|..:..|.:.|      |::.:..|.   |.::..:|::
Human   438 -----GEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVY 497

  Fly   512 ETEDTNDPRYL----LVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGE--RV 570
            .|  .|.|...    :.:|||||.:::||:.|.:...:..:...:|:...:...|.|...:  |.
Human   498 CT--PNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRC 560

  Fly   571 LGFCDFMLP-------SDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAG 628
            |.......|       .:...|..|:.|        ||.|||.:.|:||||..|..:|..||.||
Human   561 LALATHDNPLRREEMHLEDSANFIKYET--------NLTFVGCVGMLDPPRIEVASSVKLCRQAG 617

  Fly   629 IKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQR--LNIPVSEVNPREAKAAVVHGAELRDV 691
            |:|||:|||:..||.||.:.:||..:.    ||:..:  ......|:||
Human   618 IRVIMITGDNKGTAVAICRRIGIFGQD----EDVTSKAFTGREFDELNP---------------- 662

  Fly   692 SSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAG 756
             |.|.|..|...   .|||..|..|..|||..|....|.|:|||||||:||||||:||:||| :|
Human   663 -SAQRDACLNAR---CFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SG 722

  Fly   757 SDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLG 821
            :.|:|.|::|:|.||||::||..|||||.|::|:|:.|.|.::||:.|:...........|..|.
Human   723 TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALI 787

  Fly   822 TVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAA--GF 884
            .|.:|.::|.||.:||.:|.:...:.|||.:|||:| .:.|::..|. ..|..||....||  |.
Human   788 PVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNP-KEPLISGWLF-FRYLAIGCYVGAATVGA 850

  Fly   885 FVYFVIMAENGFLPK-KLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQ 948
            ..::.|.|:.|  |: ..:.:......|  .|..|..|.:....:.   .|....|..: :|.::
Human   851 AAWWFIAADGG--PRVSFYQLSHFLQCK--EDNPDFEGVDCAIFES---PYPMTMALSV-LVTIE 907

  Fly   949 WADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLS----YCPGMEKGLRMYPLKLVWWFPA 1009
            ..:.:...:...|:.:  |..|. |..||....|:..|.    |...:....::.||.:..|...
Human   908 MCNALNSLSENQSLLR--MPPWE-NIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMV 969

  Fly  1010 IPFALAIFIYDETRRFYLRR--NPG 1032
            :..:|.:.:.|||.:|..|.  .||
Human   970 LKISLPVILMDETLKFVARNYLEPG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	315/1065 (30%)
		Cation_ATPase_N	58..132	CDD:214842	18/70 (26%)
		E1-E2_ATPase	152..383	CDD:278548	75/252 (30%)
		Cation_ATPase	445..539	CDD:289987	29/117 (25%)
		COG4087	<695..770	CDD:226572	38/74 (51%)
		Cation_ATPase_C	817..1025	CDD:279079	52/214 (24%)
ATP2A2	NP_733765.1	Cation_ATPase_N	4..72	CDD:279080	17/67 (25%)
		ATPase-IIA1_Ca	53..988	CDD:273452	298/1008 (30%)
		E1-E2_ATPase	93..340	CDD:278548	75/251 (30%)
		Cation_ATPase	419..527	CDD:289987	29/117 (25%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:18971376	575..594		6/26 (23%)
		HAD	<605..711	CDD:289480	48/129 (37%)
		Cation_ATPase_C	783..986	CDD:279079	52/215 (24%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		7/19 (37%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250\|UniProtKB:O55143	788..1042		54/220 (25%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920