Protein Alignment Atpalpha and ATP1A4

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_653300.2
• Gene: ATP1A4 / 480
• HGNCID: 14073
• Length: 1029
• Species: Homo sapiens
• Alignment Length: 1023
• Identity: 725/1023 - (70%)
• Similarity: 849/1023 - (82%)
• Gaps: 2/1023 - (0%)

  Fly    19 TVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSH 83
            ||...|...|....:...::||..:..:|.|:::||:|:.:|.||::.|||..::......|.||
Human     9 TVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSH 73

  Fly    84 AKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNL 148
            .:|||.|.|.|||.:|||..|||||||||.|||||::|||.||||||||||||...:|||..|||
Human    74 QRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNL 138

  Fly   149 YLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKF 213
            ||.||||.||||||.||||||:|||||||||||||||.|.|||.|||:.:..:::||||:||:|.
Human   139 YLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKG 203

  Fly   214 GDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVIS 278
            |||:|||:|:|.|:..||||||||||||||||..:|||||||||:|:.|||||.|||||:|:||:
Human   204 GDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIA 268

  Fly   279 CGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLI 343
            .||.|||||||.|.|||..|:||||.||.|||||||.||||||||||.::.:|||.||:|:||||
Human   269 TGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLI 333

  Fly   344 GIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 408
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Human   334 GIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 398

  Fly   409 MWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAA 473
            ||||..:.||||||:|:|..:.::|..:..|:|||.|||||:||..|:.:||.|:..:|||||:|
Human   399 MWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESA 463

  Fly   474 LLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCST 538
            |||.:|.:...|..:|::|.|:||:|||||||||:|||..||::. .::|:||||||||||.|||
Human   464 LLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQ-THVLMMKGAPERILEFCST 527

  Fly   539 IFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRF 603
            ..:||:|..:::||||||.|||:|||||||||||||...||| .:..||.||||:||||:|||.|
Human   528 FLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPS-SFSKGFPFNTDEINFPMDNLCF 591

  Fly   604 VGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNI 668
            |||:||||||||||||||:|||||||||||||||||||||||||.|||||||.||.|::|.||.|
Human   592 VGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKI 656

  Fly   669 PVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVT 733
            |:|:|:...|||.|||||||:|:.|.|||:||:.|.|||||||||||||||||||||:||:||||
Human   657 PISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVT 721

  Fly   734 GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 798
            ||||||||||||||||:||||:|||||||||||||||||||||||||||||||||||||||.|||
Human   722 GDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTL 786

  Fly   799 TSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLV 863
            |||||||:|||.||:..|||||||:||||||||||||||||||||.||:|||||.||:|..|.||
Human   787 TSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLV 851

  Fly   864 NSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRD 928
            |.|||.|||||||||||.||||.||||:|||||.|..|.|||..|:.|.:|||.|||||:|||..
Human   852 NHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQ 916

  Fly   929 RKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGME 993
            ||.:|:||.||||::|||||||||||.||||||:|||||||..|.||::.||:|||||||.|||:
Human   917 RKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMD 981

  Fly   994 KGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ..|||||||:.||..|||:::.||:|||.|:..:|::|.||:|:||||
Human   982 VALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	717/995 (72%)
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/27 (22%)
		P-type_ATPase_Na-K_like	70..1026	CDD:319794	704/957 (74%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..242		15/18 (83%)