DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP12A

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001172014.1	Gene:	ATP12A / 479	HGNCID:	13816	Length:	1045	Species:	Homo sapiens

Alignment Length:	1031	Identity:	644/1031 - (62%)
Similarity:	797/1031 - (77%)	Gaps:	13/1031 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VIATDDDNRTADG--QYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLS 82
            ::.||    ..||  :|:..:....::.||.:.::.::||.:|.||:|..||.:::.|....|||
Human    19 IVKTD----KGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLS 79

  Fly    83 HAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDN 147
            ..:|.|.|.|||||:|||||||||.|||.|.:.|||::|||:||.||::||.||.|:.:..:.:|
Human    80 STRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNN 144

  Fly   148 LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVK 212
            :|||.||..|||:||||:||||:||:.||.||..|:||.|.|||:.||.|:.:|.||:||:||||
Human   145 VYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVK 209

  Fly   213 FGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE------GT 271
            .||:||||||::.::..:|||||||||||||.|.:||||||||||||:.|:||..:|      ||
Human   210 GGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEASTSPVGT 274

  Fly   272 AKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWL 336
            ..|:||:.||.|::|.||.||||:...:||||.||.||:|::.||||.:|:.||:||..|.|..|
Human   275 VTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVL 339

  Fly   337 DAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQ 401
            |::|||||||||||||||||||||.|:|||||||.||||||||||||||||||.|||||||||||
Human   340 DSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQ 404

  Fly   402 NRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVS 466
            |||||||:||||||..|||:||.|...:|::|..:.:||:|.|||||||||.||:.|||:||.|.
Human   405 NRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVI 469

  Fly   467 GDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPER 531
            |||||.||||..|:.|||||.|||||:|:||:|||||||:|:||||.:|.:..|:|:||||||||
Human   470 GDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPER 534

  Fly   532 ILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINF 596
            |||:||||.|||:|..||:...:.|:.||||||||||||||||...||:|::|..:.|:.|.:||
Human   535 ILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNF 599

  Fly   597 PIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVED 661
            |..||.||||:|||||||:.|||||.|||||||||||||||||||||||||||||||..:|||||
Human   600 PTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVED 664

  Fly   662 IAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRM 726
            ||.||||.|.:||.|:||||||.|.||:|:||:||||||..:.|||||||||||||||||||||.
Human   665 IAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQ 729

  Fly   727 GAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK 791
            .|:||||||||||||||||||||:||||||||.:|.||||:||||||||||||||||||||||||
Human   730 DAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLK 794

  Fly   792 KSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRD 856
            |:|||:||.||.|:.|||.:|:..:|||:||:|||.||||||::|:|:||||.||:|||.|.||.
Human   795 KTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRH 859

  Fly   857 PFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYG 921
            ...|:|||..|...:|..||::||...|.|||.:.|:.||||:.|..:|..|:...||||.||||
Human   860 KNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYG 924

  Fly   922 QEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGM-RNWALNFGLVFETVLAAF 985
            ||||...|:.||:|.:||||:.|:|.|.|||||.|||||||||||: ||..:..|:..:.::...
Human   925 QEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLI 989

  Fly   986 LSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            |||..|....|....|:..:||.|:|.|:.|::|||.|:.::|..||.|.::..||
Human   990 LSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	637/1002 (64%)
		Cation_ATPase_N	58..132	CDD:214842	41/73 (56%)
		E1-E2_ATPase	152..383	CDD:278548	152/236 (64%)
		Cation_ATPase	445..539	CDD:289987	67/93 (72%)
		COG4087	<695..770	CDD:226572	62/74 (84%)
		Cation_ATPase_C	817..1025	CDD:279079	108/208 (52%)
ATP12A	NP_001172014.1	ATPase-IIC_X-K	42..1045	CDD:273445	637/1002 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830