DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and ATP1A3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001243143.1	Gene:	ATP1A3 / 478	HGNCID:	801	Length:	1026	Species:	Homo sapiens

Alignment Length:	1032	Identity:	783/1032 - (75%)
Similarity:	892/1032 - (86%)	Gaps:	9/1032 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74
            |.:||||:||.....||.   |...|::.|      ::.:|||||:|:.:..||:|.||:.:::.
Human     4 GGSDSYRIATSQDKKDDK---DSPKKNKGK------ERRDLDDLKKEVAMTEHKMSVEEVCRKYN 59

  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139
            |....||:|:||:|.|.||||||||||..||||||||:.|||||::||||||||||:||.|||.|
Human    60 TDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGT 124

  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204
            .::|:.|||||||||:||||:||.||||||:|||||||||||||||.|.|||||||:.:.||::|
Human   125 EDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVV 189

  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269
            :||:||:|.|||:|||:|||.|...||||||||||||||:|..:.||:|||||:|:.|||||.||
Human   190 VGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVE 254

  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334
            |||:|||::.||.|||||||.|||||:.|:||||.||.|||.|||||||||||:||:::.||||.
Human   255 GTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYT 319

  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399
            ||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Human   320 WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 384

  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464
            ||||||||||||||||.||||||||||..:|::|..:.|||.||.|||||.||||||.:|:||::
Human   385 TQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRD 449

  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529
            |:|||||:|||||:||:.|.|..:|:||||:||:|||||||||:|||||||.||.||||||||||
Human   450 VAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAP 514

  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594
            ||||:|||||.:.|||:.|||||||||.|||:|||||||||||||.:.||.:::|.||.|:.||:
Human   515 ERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDV 579

  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659
            ||..|||.|||||||||||||||||||.|||||||||||||||||||||||||.|||||||||||
Human   580 NFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETV 644

  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724
            ||||.|||||||:||||:|||.|:||.:|:|.:|:|:||||:.||||||||||||||||||||||
Human   645 EDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQ 709

  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   710 RQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 774

  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854
            ||||||||||||||||:|||.||:.:|||||||:||||||||||||||||||||.||:|||||.|
Human   775 LKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQP 839

  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919
            |:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|||..||.:.||||.||
Human   840 RNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDS 904

  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAA 984
            |||:|||..||.:|:|||||||:|||||||||||||||||||:|||||:|..|.|||..||.|||
Human   905 YGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAA 969

  Fly   985 FLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||||||||:..|||||||..|||.|.|::..||:|||.|:..||||||||:|:||||
Human   970 FLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	769/995 (77%)
		Cation_ATPase_N	58..132	CDD:214842	46/73 (63%)
		E1-E2_ATPase	152..383	CDD:278548	178/230 (77%)
		Cation_ATPase	445..539	CDD:289987	71/93 (76%)
		COG4087	<695..770	CDD:226572	70/74 (95%)
		Cation_ATPase_C	817..1025	CDD:279079	158/207 (76%)
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	770/1001 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I438
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113729
Inparanoid	1	1.050	1568	1.000	Inparanoid score	I89
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm41159
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3604
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910