DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atpalpha and ATP1A2

DIOPT Version :9

Sequence 1:NP_732572.1 Gene:Atpalpha / 48971 FlyBaseID:FBgn0002921 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_000693.1 Gene:ATP1A2 / 477 HGNCID:800 Length:1020 Species:Homo sapiens


Alignment Length:1021 Identity:769/1021 - (75%)
Similarity:879/1021 - (86%) Gaps:13/1021 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 GQYKSRRKMPA----------KVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKA 86
            |:...|...||          |..|::.||:||:|:.:|.||:|.:||.:::|.....||::.:|
Human     2 GRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRA 66

  Fly    87 KENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLG 151
            ::.|.||||||||||..||||||||:.|||||::||||||||||:||.|||:..:||::||||||
Human    67 QDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLG 131

  Fly   152 IVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDR 216
            :||:|||||||.||||||:||||||:||||||||.|.|||||||:.:.||::|:||:||||.|||
Human   132 VVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDR 196

  Fly   217 IPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGD 281
            :|||:|||.:...||||||||||||||:|..||||||||||:|:.|||||.|||||:|:||:.||
Human   197 VPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGD 261

  Fly   282 HTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGII 346
            .|||||||.|||||:.|.||||.||.|||.|||||||||||:|||::.||||.||:|||||||||
Human   262 RTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGII 326

  Fly   347 VANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF 411
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
Human   327 VANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF 391

  Fly   412 DNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLK 476
            ||||.||||||||||..:|:.||.:.||||||.|||||.||.||:.:.:.|::.:|||||:||||
Human   392 DNQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLK 456

  Fly   477 CMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPR-YLLVMKGAPERILERCSTIF 540
            |:||:.|.|..:|.||.|:||:|||||||||:||||.||:  |: ::|||||||||||:|||||.
Human   457 CIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDS--PQSHVLVMKGAPERILDRCSTIL 519

  Fly   541 INGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVG 605
            :.|||..||:||::||.|||||||||||||||||...|||.|:|.||||:||::|||.:.|.|||
Human   520 VQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVG 584

  Fly   606 LMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPV 670
            ||||||||||||||||.|||||||||||||||||||||||||.|||||||||||||||.|||||:
Human   585 LMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPM 649

  Fly   671 SEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGD 735
            |:||||||||.||||::|:|::|:||||||:.|||||||||||||||||||||||.|||||||||
Human   650 SQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD 714

  Fly   736 GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 800
            ||||||||||||||:||||:|||||||||||||||||||||||||||||||||||||||||||||
Human   715 GVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS 779

  Fly   801 NIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNS 865
            |||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.||:...|||||.
Human   780 NIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNE 844

  Fly   866 RLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRK 930
            |||||||||||||||..|||.||||:|||||||.:|.|||..||.:.:|||.|||||||||..||
Human   845 RLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRK 909

  Fly   931 TLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKG 995
            .:|:|||||||.|||||||||||||||||||:|||||:|..|.|||:.||.|||||||||||...
Human   910 VVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVA 974

  Fly   996 LRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            |||||||:.|||.|.|::|.||||||.|:..|||.||||:|:||||
Human   975 LRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY 1020

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AtpalphaNP_732572.1 ATPase-IIC_X-K 45..1041 CDD:273445 762/996 (77%)
Cation_ATPase_N 58..132 CDD:214842 44/73 (60%)
E1-E2_ATPase 152..383 CDD:278548 181/230 (79%)
Cation_ATPase 445..539 CDD:289987 60/94 (64%)
COG4087 <695..770 CDD:226572 69/74 (93%)
Cation_ATPase_C 817..1025 CDD:279079 160/207 (77%)
ATP1A2NP_000693.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 6/28 (21%)
ATPase-IIC_X-K 30..1020 CDD:273445 761/991 (77%)
Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250 80..82 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..231 15/18 (83%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 476 1.000 Domainoid score I438
eggNOG 1 0.900 - - E2759_KOG0203
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1568 1.000 Inparanoid score I89
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D388324at2759
OrthoFinder 1 1.000 - - FOG0000283
OrthoInspector 1 1.000 - - otm41159
orthoMCL 1 0.900 - - OOG6_100215
Panther 1 1.100 - - LDO PTHR43294
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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