DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atpalpha and ATP1A1

DIOPT Version :9

Sequence 1:NP_732572.1 Gene:Atpalpha / 48971 FlyBaseID:FBgn0002921 Length:1041 Species:Drosophila melanogaster
Sequence 2:NP_000692.2 Gene:ATP1A1 / 476 HGNCID:799 Length:1023 Species:Homo sapiens


Alignment Length:1032 Identity:771/1032 - (74%)
Similarity:888/1032 - (86%) Gaps:14/1032 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74
            || |.|..|.|....|             |...|..|..::|:||:|:.:|.||:|.:||::::.
Human     6 GR-DKYEPAAVSEQGD-------------KKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYG 56

  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139
            |....||:.|:|.|.|.||||||||||..||||:|||:.|||||:|||||||||||:||||||:|
Human    57 TDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAAT 121

  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204
            .|||.:||||||:|||||||:||.||||||:|||||||||||||||.|.|||.|||:::.||::|
Human   122 EEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVV 186

  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269
            :||:||||.|||||||:|||.|...||||||||||||||:|..:||:||||||:|:||||||.||
Human   187 VGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVE 251

  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334
            |||:|:|:..||.|||||||.|||||:.|:||||.||.||||:||||||||||:||:::.||.|.
Human   252 GTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYT 316

  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399
            ||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Human   317 WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 381

  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464
            ||||||||||||||||.||||||:||||.:|:||..:.||||||.|||||.|:..|:.:||||:.
Human   382 TQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRA 446

  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529
            |:|||||:|||||:||..|.|..:|:|..||.|:|||||||||:|||:..:|::|::||||||||
Human   447 VAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAP 511

  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594
            ||||:|||:|.::|||:.||||:|:||.|||:|||||||||||||...||.:::|.||:|:|||:
Human   512 ERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDV 576

  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659
            |||||||.||||:||||||||||||||.|||||||||||||||||||||||||.|||||||||||
Human   577 NFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETV 641

  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724
            ||||.|||||||:||||:|||.||||::|:|::|:|||:||:|||||||||||||||||||||||
Human   642 EDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQ 706

  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   707 RQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 771

  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854
            ||||||||||||||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.|
Human   772 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP 836

  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919
            |:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|:|..||.:.:||:.||
Human   837 RNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDS 901

  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAA 984
            |||:|||..||.:|:|||||||:||||||||||:||||||||:|||||:|..|.|||..||.|||
Human   902 YGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAA 966

  Fly   985 FLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||||||||...|||||||..|||.|.|::|.||:|||.|:..:||.||||:|:||||
Human   967 FLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AtpalphaNP_732572.1 ATPase-IIC_X-K 45..1041 CDD:273445 760/995 (76%)
Cation_ATPase_N 58..132 CDD:214842 46/73 (63%)
E1-E2_ATPase 152..383 CDD:278548 179/230 (78%)
Cation_ATPase 445..539 CDD:289987 60/93 (65%)
COG4087 <695..770 CDD:226572 71/74 (96%)
Cation_ATPase_C 817..1025 CDD:279079 156/207 (75%)
ATP1A1NP_000692.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 13/46 (28%)
ATPase-IIC_X-K 30..1023 CDD:273445 759/992 (77%)
Phosphoinositide-3 kinase binding. /evidence=ECO:0000250 82..84 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..235 13/18 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 476 1.000 Domainoid score I438
eggNOG 1 0.900 - - E2759_KOG0203
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1568 1.000 Inparanoid score I89
Isobase 1 0.950 - 0 Normalized mean entropy S851
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D50082at33208
OrthoFinder 1 1.000 - - FOG0000283
OrthoInspector 1 1.000 - - otm41159
orthoMCL 1 0.900 - - OOG6_100215
Panther 1 1.100 - - O PTHR43294
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3604
SonicParanoid 1 1.000 - - X416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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