DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and atp2b1a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_021330641.1	Gene:	atp2b1a / 378746	ZFINID:	ZDB-GENE-030925-29	Length:	1266	Species:	Danio rerio

Alignment Length:	1171	Identity:	310/1171 - (26%)
Similarity:	496/1171 - (42%)	Gaps:	316/1171 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ADGQYKSRRKMPAKVNKKE----NLDDLKQELDI----DFHKISPEELY-------QRFQTHPEN 79
            |:..|...:...|:.|...    :|.:|:..:::    ...||  :|.|       .|.:|...:
Zfish     2 ANNSYSGVKNSVAEPNHNGEFGCSLKELRSLMELRGAEGLQKI--QETYGDVNGLCNRLKTSAVD 64

  Fly    80 GLSHAKAKENLERD----GPNALTPPKQTPEWVKFCKNLFGGFAMLLW-----IGAILCFVAYSI 135
            |||...:  ::|:.    |.|.: |||:...           |..|:|     :..|:..||..:
Zfish    65 GLSGQPS--DIEKRKAAFGQNFI-PPKKPKT-----------FLQLVWEALQDVTLIILEVAAIV 115

  Fly   136 QASTS----EEPADDNLYLG------------------IVLSAV-VIVTGIFSYYQESKSSKIME 177
            ....|    .:..|.|...|                  |:||.| |::...|:.:.:.|..:.::
Zfish   116 SLGLSFYKPPDAGDKNCVKGTGGEPEEEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQ 180

  Fly   178 SFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEP 242
            |......:| :|:|.|:.:.:...::|:||:.::|:||.:|||..:|:..:.|:|.|||||||:.
Zfish   181 SRIEQEQKF-SVVRGGQVIQIHVAEIVVGDIAQIKYGDLLPADGILIQGNDLKIDESSLTGESDH 244

  Fly   243 QSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGL---------------- 291
            ..:.        |:...:....|:.:||:.|.||.:.|.::..|.|..|
Zfish   245 VKKS--------LDKDAMLLSGTHVMEGSGKIVVTAVGVNSQTGIIFTLLGAGEDDDDEEEKEKK 301

  Fly   292 ------------------------------------------ASGLDTGETPIAKEIHHFIH-LI 313
                                                      |.|.:..:..:.|:....:. .:
Zfish   302 KEKERKKEKKNKKQDGSVENRKKAKAQDGAAMEMQPLNSDEGADGEEKRKANLPKKEKSVLQGKL 366

  Fly   314 TGVAVFLG----------VTFFVIAFILGYHWLDAV----------------IFLIG--IIVANV 350
            |.:||.:|          |...|:.|::...|:|.:                .|:||  ::|..|
Zfish   367 TKLAVQIGKAGLLMSAITVIILVVLFVVDTFWVDKIPWDSGCIPIYIQFFVKFFIIGVTVLVVAV 431

  Fly   351 PEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWF---- 411
            ||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||..::.
Zfish   432 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQVFIADKH 496

  Fly   412 -----DNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASE 471
                 :..::.|.|        .|....|........|.....|.:||      |.::| |:.:|
Zfish   497 YRKVPEPDVVPAST--------MDLLIVGISVNCAYTTKIMSPEKEGG------LNRQV-GNKTE 546

  Fly   472 AALLKCMELALGDVMNIRKRNKKIA-EVP---------FNSTNKYQVSIHETEDTNDPRYLLVMK 526
            .||       ||..::::|..:.:. |:|         |||..|...::.:.:|.:   |.:..|
Zfish   547 CAL-------LGFALDLKKDYQAVRNEIPEEKLYKVYTFNSVRKSMSTVLKNDDGS---YRMFSK 601

  Fly   527 GAPERILERCSTIFIN-GKEKVL-----DEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPN 585
            ||.|.:|::|..|..: |:.||.     |:.:|........|  ||....|.:.||. .|:..|:
Zfish   602 GASEILLKKCFKILTSTGEAKVFRPRDRDDMVKRVIEPMASE--GLRTICLAYRDFP-ASEGEPD 663

  Fly   586 GFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVG 650
            .  .|..||   :..|..|.::.:.||.|..||||:.||:.|||.|.|||||:..||:|||...|
Zfish   664 W--DNEADI---LTRLTCVCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNLNTARAIATKCG 723

  Fly   651 IISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---LRYHTEIVFARTS 712
            |:..|::.       |.:...|.|.|...       |..::..:::|:|   ||     |.||:|
Zfish   724 ILQVGDDF-------LCLEGKEFNRRIRN-------EKGEIEQERIDKIWPKLR-----VLARSS 769

  Fly   713 PQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLD 770
            |..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||||:||:|:|:|:||.|
Zfish   770 PTDKHTLVKGIIDSTVVEQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTD 832

  Fly   771 DNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPLPLGTVTILCIDLG 831
            |||:|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||.  .|.:|.::|.
Zfish   833 DNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPLK--AVQMLWVNLI 893

  Fly   832 TDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVY-FVIMAENG 895
            .|.:.:::||.|.....::.|.|...      |..|||..     |::...|..|| .:|:....
Zfish   894 MDTLASLALATEPPTESLLLRKPYGR------NKPLISRT-----MMKNILGHAVYQLIIIFTLL 947

  Fly   896 FLPKKLFGIRKMWDSKAVNDLTDSYGQEWT--------------------YRDRKTLEYTCHT-- 938
            |..:|:|.|    ||....||.....:.:|                    :.:|...|...:.
Zfish   948 FAGEKMFNI----DSGRYADLHAPPSEHYTIVFNTFVMMQLFNEINARKIHGERNVFEGIFNNMI 1008

  Fly   939 -------AFFISIVVVQWADLIICKTRRNSIFQQGMRNW---------ALNFGLVFETVLAAFLS 987
                   .|.|.||:||:..      :..|.....:..|         .|.:|.|..|:..:.|:
Zfish  1009 FCTIVFGTFVIQIVIVQFGG------KPFSCVGLNIEQWLWCIFLGFGCLLWGQVISTIPTSRLT 1067

  Fly   988 Y 988
            :
Zfish  1068 F 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	307/1156 (27%)
		Cation_ATPase_N	58..132	CDD:214842	19/93 (20%)
		E1-E2_ATPase	152..383	CDD:278548	73/318 (23%)
		Cation_ATPase	445..539	CDD:289987	26/103 (25%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	44/211 (21%)
atp2b1a	XP_021330641.1	E1-E2_ATPase	10..1064	CDD:332568	307/1157 (27%)
atp2b1a	XP_021330641.1	ATP_Ca_trans_C	1105..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010