DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and Atp13a2

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_006239308.1	Gene:	Atp13a2 / 362645	RGDID:	1307977	Length:	1173	Species:	Rattus norvegicus

Alignment Length:	920	Identity:	217/920 - (23%)
Similarity:	343/920 - (37%)	Gaps:	222/920 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GPNALTPPKQTPEWVKFCKNL-----------FGGFAMLLWIGAILCFVAYSIQASTSEEPADDN 147
            |||.:..|      ||....|           |..|::.||:                   ||..
  Rat   212 GPNVIGIP------VKSYLQLLVDEALNPYYGFQAFSIALWL-------------------ADHY 251

  Fly   148 LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGD-VVEV 211
            .:..:.:..:..::...|.|:..|.|..:.....:..:.......||:..:.:.:||.|| :|..
  Rat   252 YWYAVCIFLISAISICLSLYKTRKQSMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLP 316

  Fly   212 KFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPL----ET--KNLAFFSTNAVEG 270
            :.|..:|.|..:: |....|:.|||||||.|..:.|  ..|.|.    ||  ::..|..|..::.
  Rat   317 QEGGMMPCDAALV-AGECVVNESSLTGESIPVLKTA--LPEGPQPYCPETHRRHTLFCGTLVLQA 378

  Fly   271 TA------KGVVISCGDHTVMGRIAGLASGLDTGETPIA-KEIHHFIHLITGVAV--FLGVTFFV 326
            .|      ..||...|..|..|   ||.|.: ....||: |...|.:..:..::|  .||..:.:
  Rat   379 RAYLGPRVLAVVTRTGFCTAKG---GLVSSI-LHPRPISFKFYRHSMKFVAALSVLALLGTIYSI 439

  Fly   327 IAFILGYHWL---DAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGST 388
            |  ||..:.:   :.||..:.::...||..|.|.:|||......|:.::.....:...:...|..
  Rat   440 I--ILYRNRVPVKEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKL 502

  Fly   389 STICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGV-------------QYDRTSPGFKALS 440
            ..:|.|||||||::.:                  |..||             :.....||  .|.
  Rat   503 RLVCFDKTGTLTEDGL------------------DIMGVVPLKGQMLLPLVPEPCHLPPG--PLL 547

  Fly   441 RIATLCNR-AEFKGGQDGVPILKKEV------------SGDASEAALLKCM----------ELAL 482
            |....|:. ::......|.|:..|.|            :|.|.|..:|..|          |.:.
  Rat   548 RALVTCHALSQLHDTLVGDPMDLKMVESTGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQEESP 612

  Fly   483 GDVMNIRKRNKKIAEVPFNST-NKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEK 546
            ..|..:|:       .||:|. .:..|.:.....|....|   :||:||.:...||
  Rat   613 EPVSVLRR-------FPFSSALQRMDVVVTWPGATQPEAY---VKGSPELVASLCS--------- 658

  Fly   547 VLDEEMKEAFNNAYMELGGLGERVLGFCDFMLP-SDKYPNGFKFNTDDINFPIDNLRFVGLMSMI 610
              .|.:...|..........|.||:......|| :.......:...|.:.   ..|..:||:.|.
  Rat   659 --PETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPSLEAAQQLTRDTVE---QELSLLGLLVMR 718

  Fly   611 DPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIA-------QRLNI 668
            :..:......:...|..||:.:|||||:..||..:||:.|::.    |.|.:|       ::...
  Rat   719 NLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTVAKACGMVG----TQEHLAIIHATHPEQGQP 779

  Fly   669 PVSEVNPREAKAAVVHGAELRDVSSDQLDE----------------ILRYH----------TEIV 707
            ...|..|.|..|| ::||:....::|...|                :|:.|          ...|
  Rat   780 AALEFLPTEPSAA-MNGAKDPVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLVQATV 843

  Fly   708 FARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIA-GSDVSKQAADMILLDD 771
            |||.:|:||..:|...||:...|.:.|||.||..|||.||:|:::..| .|.||...:.|..::
  Rat   844 FARMAPEQKTQLVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIE- 907

  Fly   772 NFASIVTGVEEGRLIFDN----LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLG- 831
               .:.|.:.|||...|.    .|....|:||..|.      ..||..|...||.:..|.|||.
  Rat   908 ---CVPTVIREGRCSLDTSFSVFKYMALYSLTQFIS------VLILYTINTNLGDLQFLAIDLFI 963

  Fly   832 TDMV--------PAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYF 888
            |..|        ||::|        :..|||....:..::.|.|:.:|.  :..||...    ||
  Rat   964 TTTVAVLMSRTGPALTL--------VRARPPGALLSVPVLGSLLLQVAL--VAGIQLGG----YF 1014

  Fly   889 VIMAENGFLP 898
            :::|:..|:|
  Rat  1015 LVIAQPWFVP 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	217/920 (24%)
		Cation_ATPase_N	58..132	CDD:214842	11/48 (23%)
		E1-E2_ATPase	152..383	CDD:278548	60/249 (24%)
		Cation_ATPase	445..539	CDD:289987	25/117 (21%)
		COG4087	<695..770	CDD:226572	30/101 (30%)
		Cation_ATPase_C	817..1025	CDD:279079	24/91 (26%)
Atp13a2	XP_006239308.1	P-ATPase-V	39..1116	CDD:273738	217/920 (24%)
		P5-ATPase	39..>110	CDD:289194
		E1-E2_ATPase	258..493	CDD:278548	60/243 (25%)
		Cation_ATPase	<621..658	CDD:289987	10/39 (26%)
		COG4087	<843..>892	CDD:226572	22/48 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000