DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and CG9981

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster

Alignment Length:	1178	Identity:	242/1178 - (20%)
Similarity:	421/1178 - (35%)	Gaps:	373/1178 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ENLERDGPNALTPPKQTPEWVKFCK-NLFGGFAMLLWI-GAILCFVAYSIQASTSEEPADDNLYL 150
            |:.::...|.:|..|.|  |..|.. |.:..|...::. ..|:..|::.:..:.|.      |..
  Fly    20 ESRQQKPLNRVTTTKYT--WFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISP------LVS 76

  Fly   151 GIVLSAVVIVTGI---FSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVK 212
            .:.|..|:|:|.:   ...|..|||.|::.:.:      .||||.|::..:.::.:|.||:|.|:
  Fly    77 LLPLLFVMIITALKEGLEDYSRSKSDKLVNTAR------VTVIRNGKEEIINSQFIVPGDLVVVR 135

  Fly   213 FGDRIPADIRIIEA----RNFKVDNSSLTGES---------------------------EPQS-- 244
            ....:|.|:.::::    |...|:.::|.||:                           ||.|
  Fly   136 NDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLKTICVPTNYLLAGDHELQGKDCIVCEPSSAD 200

  Fly   245 ----------------RGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLAS 293
                            .|:......||...||...... |:.|.:  |:.|..:|.|.....|.|
  Fly   201 LYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVR-VKSTER--VVGCAIYTGMHTKLQLNS 262

  Fly   294 GLDTGETPIAKE--IHHF-IHLITGVAVFLGVTFFV-------IAFILGYH---------WLDAV 339
            .. ||....:.|  |:.| :.||.|:.|.:.|.:.:       |...:.|.         |....
  Fly   263 RY-TGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFE 326

  Fly   340 IFLIGIIVANVPEGLLATVTVCLTLTAKRM----------------ASKNCLVKNLEAVETLGST 388
            .||..:::.|    .:..::..:.:...|:                ..:.|.|......|.||..
  Fly   327 DFLSFLLLFN----YMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQV 387

  Fly   389 STICSDKTGTLTQNRMTVAHMW---------------------FDNQIIEAD------------T 420
            :.:.||||||||:|.|...:.:                     |:.:.::||            |
  Fly   388 NILFSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHT 452

  Fly   421 TEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLK-CMELAL-- 482
            .|....|. |:|....:::|..:.|.:|          .|:.:..:....|.|||: |..|.|
  Fly   453 VEVLQEVG-DKTLESSESVSEQSHLMSR----------NIVDRYQASSPDEKALLEGCASLGLVY 506

  Fly   483 ----GDVMNI-------RKRNKKIAEVPFNS-TNKYQVSIHETEDTNDPRYLLVMKGAPERILER 535
                .||::|       :.:.|::..:.|:| ..:..|.:.:..||    ..|..|||...|..|
  Fly   507 EGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDT----IWLYSKGAESAIFPR 567

  Fly   536 CS---------------------TIFINGKEKVLDEEM---KEAFNNAYMELGGLGERVLGFCDF 576
            |.                     |:.: |:..:.|:|:   :|.:..|..:|....| ::..|
  Fly   568 CKASPLVEQTDAQITKYAQNGLRTMAV-GRRMLTDDELFHFEELYRKANTQLSNRNE-LIASC-- 628

  Fly   577 MLPSDKYPNGFKFNTDDINFPIDN-LRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPI 640
                        :.|      ::| |..:|..::.|..:..|.:.:...::||:|:.::|||...
  Fly   629 ------------YET------VENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVE 675

  Fly   641 TAKAIAKSVGIISEGNE------TVE--DIAQRLNIPVSEVNPREAKAAVVHG----AELRDVSS 693
            ||..|..:...|..|::      |.|  ::..||::    :...|.:..:|.|    |.|.....
  Fly   676 TAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDM----IGDDEPEVLIVDGTTITALLEHTPR 736

  Fly   694 DQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGA-IVAVTGDGVNDSPALKKADIGVAMGIAGS 757
            ...|..||... ::..|.||.||..||...:|... |.|..|||.||...:::|.||:  ||.|.
  Fly   737 QFADLALRCRA-VLCCRLSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGI--GITGR 798

  Fly   758 DVSKQAA--------------DMILLDDNFAS---------------IVTGVEEGRLIFD----- 788
            : .||||              .:.|:..::.|               |:||......::|
  Fly   799 E-GKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSAT 862

  Fly   789 NLKKSIAYTLTSNIPEIS-PFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKR 852
            |:..|| |....:|..|| .|....:||                          .:::|..::..
  Fly   863 NVYNSI-YLWLFDIVYISFSFTVLAICD--------------------------KDYSEETLLSH 900

  Fly   853 PPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLT 917
            |   .....|.::|            ||:.|.|..:::   |||:  :.| |...:....:||..
  Fly   901 P---ELYKPLAHNR------------QASMGVFSLWIL---NGFV--QCF-IIFFFTYAMLNDAN 944

  Fly   918 DSY--GQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIIC---KTRRNSIFQQGMRNWALNFGLV 977
            ..:  ||..:::       |..|.....||:|....|::.   .|.|             ||.::
  Fly   945 VLFNGGQTASFQ-------TFGTMLITIIVIVGNLKLLLVAHYMTYR-------------NFAMI 989

  Fly   978 FETVLAAFLS------YCPG-----MEKGLRMYPLKLVWWFPAI--------PFALAIFIYDETR 1023
            ..::.|..|:      |..|     ..:.|...|   :|.|..|        .|.:.: :.|..|
  Fly   990 LASIAAFMLTTYLYNLYTSGELYDVYNQFLSSLP---IWLFTIICSVACLLPDFVIKV-VNDMYR 1050

  Fly  1024 RFYLRRNP 1031
            :..|:..|
  Fly  1051 KVPLKSKP 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	242/1178 (21%)
		Cation_ATPase_N	58..132	CDD:214842	10/45 (22%)
		E1-E2_ATPase	152..383	CDD:278548	61/317 (19%)
		Cation_ATPase	445..539	CDD:289987	26/129 (20%)
		COG4087	<695..770	CDD:226572	29/89 (33%)
		Cation_ATPase_C	817..1025	CDD:279079	39/231 (17%)
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	11/47 (23%)
		ATPase-Plipid	28..1051	CDD:273734	238/1161 (20%)
		E1-E2_ATPase	84..>189	CDD:278548	24/110 (22%)
		Cation_ATPase	<489..568	CDD:289987	21/82 (26%)
		HAD_like	<758..807	CDD:304363	21/51 (41%)
		PhoLip_ATPase_C	804..1050	CDD:292829	55/317 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910