DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP7

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	952	Identity:	185/952 - (19%)
Similarity:	325/952 - (34%)	Gaps:	325/952 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 TPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFS--- 165
            ||  |:|    ||||             .:.:|:..:.:....|  :.:::|.|..::.::|
  Fly   424 TP--VQF----FGGF-------------HFYVQSYRAIKHGTTN--MDVLISMVTTISYVYSVAV 467

  Fly   166 ----YYQESKSSKIMESFKNMVPQFATVIREG----------------EKLTLRAEDLVL----- 205
                ...|..||.:  :|.:..|.....|..|                :.|:|:|.|.:|
  Fly   468 VIAAVLLEQNSSPL--TFFDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISP 530

  Fly   206 -----------------GDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSR-------G 246
                             ||:::|..|.::|.|.:::...: ..|.|.:||||.|.::       |
  Fly   531 DFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGHS-SCDESLITGESMPVAKRKGSVVIG 594

  Fly   247 AEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPI---AKEI-H 307
            ........|           .||.|      ..|::|.:.:|..|.....|.:.||   |..| .
  Fly   595 GSINQNGVL-----------LVEAT------HTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAG 642

  Fly   308 HFIHLITGVAVFLGVTFFVIAF---------------------ILGYHWLDAVIFLIGIIVANVP 351
            :|:..:..|:....:.:.:|.|                     |:.|.:..|    :.::....|
  Fly   643 YFVPFVVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCA----LSVLAIACP 703

  Fly   352 EGL-LATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQ-----NRMTVAHMW 410
            ..| |||.|..:..|... |....|||...|:|......|:..|||||:|.     :::|:
  Fly   704 CALGLATPTAVMVATGTG-AINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTL---- 763

  Fly   411 FDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKG-----------GQDGVPILKKE 464
                .:.|...                :|:|..|:...||...           .:|.:.:....
  Fly   764 ----FVTAQVC----------------SLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATP 808

  Fly   465 VSGDASEAALLKCM------------ELALGDVMNIRK--------RNKKIAEVPFNSTNKY--- 506
            .:|...:::..:.:            |..|....|..:        |......||.::....
  Fly   809 QAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHL 873

  Fly   507 --QVSIHETEDTNDPRYL--LVMKGAPERILERCSTIFINGKEKVLD--EEMKEAFNNAYMELGG 565
              |.|:.::.:.|:.:.|  ||::...|.:.:          :|::|  |.:....|..:||...
  Fly   874 LPQRSVRKSMELNNQQLLSDLVLEPEEELLTD----------QKIIDSPEILVLIGNREWMERNA 928

  Fly   566 LGERVLGFCDFMLPSDKYP--------NGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVA 622
            : |..|...|.|...::..        ||               :.|.:.::.|..:.....||.
  Fly   929 I-EVPLEISDCMTHEERKGHTAVLCALNG---------------QLVCMFAVSDMVKPEAHLAVY 977

  Fly   623 KCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAE 687
            ..:..||.|:::|||:..||.:||:.|||
  Fly   978 TLKRMGIDVVLLTGDNKNTAASIAREVGI------------------------------------ 1006

  Fly   688 LRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAM 752
                             ..|:|...|..|:..::..|..|..||:.||||||||||.:||:|:.:
  Fly  1007 -----------------RTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITI 1054

  Fly   753 GIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN---IPEISPFLA---F 811
            . ||:||:.:|:|::|:.::...:|..::..|.....::.:..:....|   ||..|...|   |
  Fly  1055 A-AGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGF 1118

  Fly   812 IL----CDIPLPLGTVTILCIDL-----------------------------GTDMVPAISLAYE 843
            .|    ..:.:...:|:::|..|                             ..|.:..:||
  Fly  1119 TLLPWMASVAMAASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSL--- 1180

  Fly   844 HAEADIMKRPPRDPFNDKLVN--SRLISMAYGQIGMIQAAAG 883
            |...|.:....|.||.....:  ||:....||.|....|..|
  Fly  1181 HRGLDDLPEKGRMPFKRSSTSLISRIFMHDYGNITSPDAKYG 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	185/952 (19%)
		Cation_ATPase_N	58..132	CDD:214842	8/27 (30%)
		E1-E2_ATPase	152..383	CDD:278548	61/308 (20%)
		Cation_ATPase	445..539	CDD:289987	17/131 (13%)
		COG4087	<695..770	CDD:226572	28/74 (38%)
		Cation_ATPase_C	817..1025	CDD:279079	18/98 (18%)
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219
		ZntA	285..1131	CDD:225127	167/856 (20%)
		HMA	287..350	CDD:238219
		E1-E2_ATPase	489..735	CDD:278548	53/268 (20%)
		COG4087	<984..1085	CDD:226572	41/154 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910