DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and Atp2b3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_006528144.1	Gene:	Atp2b3 / 320707	MGIID:	1347353	Length:	1249	Species:	Mus musculus

Alignment Length:	1067	Identity:	297/1067 - (27%)
Similarity:	468/1067 - (43%)	Gaps:	288/1067 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LYQRFQTHPENGLSHAKAKENLERD----GPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILC 129
            |.:|.:|.|..||  |....:||:.    |.|.: ||||...:::..........:::...|.:.
Mouse    59 LCRRLKTSPTEGL--ADNTNDLEKRRQIYGQNFI-PPKQPKTFLQLVWEALQDVTLIILEVAAIV 120

  Fly   130 FVAYSIQASTSEEP---------ADDN------------LYLGIVLSAVVIVTGIFSYYQESKSS 173
            .:..|..|...||.         |:|.            :.|.::  .||:||. |:.:.:.|..
Mouse   121 SLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVI--CVVLVTA-FNDWSKEKQF 182

  Fly   174 KIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTG 238
            :.::|......:| ||||.|:.|.:....||:||:.:||:||.:|||..:|:..:.|:|.|||||
Mouse   183 RGLQSRIEQEQKF-TVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTG 246

  Fly   239 ESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGL--ASG------- 294
            ||:...:.|:   ::|     :....|:.:||:.:.||.:.|.::..|.|..|  |.|
Mouse   247 ESDHVRKSAD---KDP-----MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKD 303

  Fly   295 ---------LDTGE-----------------------------------------------TPIA 303
                     :|:.:                                               |.:|
Mouse   304 KKGKQQDGAMDSSQTRAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANVPKKEKSVLQGKLTKLA 368

  Fly   304 KEIHHFIHLITGVAVFLGVTFFVI-AFIL-GYHWLD----------AVIFLIG--IIVANVPEGL 354
            .:|.....:::.:.|.:.|.:||| .|:: |..||.          ...|:||  ::|..|||||
Mouse   369 VQIGKAGLVMSAITVIILVLYFVIETFVVDGRVWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGL 433

  Fly   355 LATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEAD 419
            ...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||...:.
Mouse   434 PLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYL-------- 490

  Fly   420 TTEDQSGVQYDRTSPGFKALS-RIATLCNRA--------------EFKGGQDGVPILKKEVSGDA 469
                  |..:.:..|...||: :|..|...|              |.:|.      |.::| |:.
Mouse   491 ------GDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGA------LPRQV-GNK 542

  Fly   470 SEAALLKCMELALGDVMNIRKRNKKIAE-VP---------FNSTNKYQVSIHETEDTNDPRYLLV 524
            :|.||       ||.|:::::..:.:.| :|         |||..|...::....|..   :.|.
Mouse   543 TECAL-------LGFVLDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGG---FRLF 597

  Fly   525 MKGAPERILERCSTIF-ING-----KEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKY 583
            .|||.|.:|::|:.|. .||     :.:..|:.:|:....  |...||....:.:.||....:.
Mouse   598 SKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKKIIEP--MACDGLRTICIAYRDFSAIQEP- 659

  Fly   584 PNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKS 648
                  :.|:.|..:.:|..:.::.:.||.|..||:|:.||:.|||.|.|||||:..||:|||..
Mouse   660 ------DWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAK 718

  Fly   649 VGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---LRYHTEIVFAR 710
            .|||..|    ||.   |.:...|.|.|...       |..::..::||::   ||     |.||
Mouse   719 CGIIQPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERLDKVWPKLR-----VLAR 764

  Fly   711 TSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMIL 768
            :||..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||||:||:|:|:|:||
Mouse   765 SSPTDKHTLVKGIIDSTTGEQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 827

  Fly   769 LDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPLPLGTVTILCID 829
            .||||.|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||.  .|.:|.::
Mouse   828 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPLK--AVQMLWVN 888

  Fly   830 LGTDMVPAISLAYEHAEADIMKRPP--RD-PFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFV-- 889
            |..|...:::||.|.....::.|.|  || |...:.:...::..|..|:.:|     |.:.||
Mouse   889 LIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTII-----FTLLFVGE 948

  Fly   890 ----------------------------IMAE--NGFLPKKLFGIRKMWDSKAVNDL--TDSYGQ 922
                                        :|.:  |....:|:.|.|.::|....|.:  |...|
Mouse   949 LFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLG- 1012

  Fly   923 EWTYRDRKTLEYTCHTAFFISIVVVQW 949
                            .|.|.||:||:
Mouse  1013 ----------------TFGIQIVIVQF 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	297/1067 (28%)
		Cation_ATPase_N	58..132	CDD:214842	16/66 (24%)
		E1-E2_ATPase	152..383	CDD:278548	80/309 (26%)
		Cation_ATPase	445..539	CDD:289987	27/117 (23%)
		COG4087	<695..770	CDD:226572	44/84 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	35/170 (21%)
Atp2b3	XP_006528144.1	ATPase-IIB_Ca	19..1061	CDD:273668	297/1067 (28%)
Atp2b3	XP_006528144.1	ATP_Ca_trans_C	1100..1175	CDD:372101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010