DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp2a2

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001104293.1	Gene:	Atp2a2 / 29693	RGDID:	2174	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1064	Identity:	315/1064 - (29%)
Similarity:	495/1064 - (46%)	Gaps:	167/1064 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAM-LLWIG 125
            |..:.||:...|..:...|||..:.|:..||.|.|.| |.::....::.....|....: :|.:.
  Rat     5 HTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNEL-PAEEGKTLLELVIEQFEDLLVRILLLA 68

  Fly   126 AILCFVAYSIQASTSE-----EPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQ 185
            |.:.||....:.....     ||        .|:..:::...|...:||..:...:|:.|...|:
  Rat    69 ACISFVLAWFEEGEETITAFVEP--------FVILLILVANAIVGVWQERNAENAIEALKEYEPE 125

  Fly   186 FATVIREGEKLT--LRAEDLVLGDVVEVKFGDRIPADIRI--IEARNFKVDNSSLTGESEPQSRG 246
            ...|.|:..|..  ::|:|:|.||:||:..||::|||||:  |::...:||.|.|||||.
  Rat   126 MGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESV----- 185

  Fly   247 AEFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIA 303
            :...|.:|:        :.||:.|..||...|.|.|||::.|.:|.:|:|.......:...||:.
  Rat   186 SVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ 250

  Fly   304 KEIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATV 358
            :::..|...::.|...:.:..::|..      :.|..|:...|:    .:.:.||.:||||.|.:
  Rat   251 QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVI 315

  Fly   359 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADT--- 420
            |.||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:..:: :|.||
  Rat   316 TTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDK-VEGDTCSL 379

  Fly   421 ----------------TEDQSGV---QYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPIL 461
                            .:|...|   |||    |...|:.|..|||.:     |.||..:.|
  Rat   380 NEFTITGSTYAPIGEVQKDDKPVKCHQYD----GLVELATICALCNDSALDYNEAKGVYEKV--- 437

  Fly   462 KKEVSGDASEAAL------LKCMELALGDVMNIRKRN------KKIAEVPFN---STNKYQVSIH 511
                 |:|:|.||      :...:..|..:..|.:.|      |::.:..|.   |.::..:|::
  Rat   438 -----GEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVY 497

  Fly   512 ETEDTNDPRYL----LVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGE--RV 570
            .|  .|.|...    :.:|||||.:::||:.|.:...:..:...:|:...:...|.|...:  |.
  Rat   498 CT--PNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRC 560

  Fly   571 LGFCDFMLP-------SDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAG 628
            |.......|       .:...|..|:.|        ||.|||.:.|:||||..|..:|..||.||
  Rat   561 LALATHDNPLRREEMHLEDSANFIKYET--------NLTFVGCVGMLDPPRIEVASSVKLCRQAG 617

  Fly   629 IKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVS- 692
            |:|||:|||:..||.||.:.:||..:.    ||:..:                ...|.|..::|
  Rat   618 IRVIMITGDNKGTAVAICRRIGIFGQD----EDVTSK----------------AFTGREFDELSP 662

  Fly   693 SDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 757
            |.|.|..|...   .|||..|..|..|||..|....|.|:|||||||:|||||::||:||| :|:
  Rat   663 SAQRDACLNAR---CFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMG-SGT 723

  Fly   758 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGT 822
            .|:|.|::|:|.||||::||..|||||.|::|:|:.|.|.::||:.|:...........|..|..
  Rat   724 AVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIP 788

  Fly   823 VTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAA--GFF 885
            |.:|.::|.||.:||.:|.:...:.|||.:|||:| .:.|::..|. ..|..||....||  |..
  Rat   789 VQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNP-KEPLISGWLF-FRYLAIGCYVGAATVGAA 851

  Fly   886 VYFVIMAENGFLPK-KLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQW 949
            .::.|.|:.|  |: ..:.:......|  .|..|..|.:....:.   .|....|..: :|.::.
  Rat   852 AWWFIAADGG--PRVSFYQLSHFLQCK--EDNPDFEGVDCAIFES---PYPMTMALSV-LVTIEM 908

  Fly   950 ADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLS----YCPGMEKGLRMYPLKLVWWFPAI 1010
            .:.:...:...|:.:  |..|. |..||....|:..|.    |...:....::.||.|..|...:
  Rat   909 CNALNSLSENQSLLR--MPPWE-NIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVL 970

  Fly  1011 PFALAIFIYDETRRFYLRR--NPG 1032
            ..:|.:.:.|||.:|..|.  .||
  Rat   971 KISLPVILMDETLKFVARNYLEPG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	315/1064 (30%)
		Cation_ATPase_N	58..132	CDD:214842	18/70 (26%)
		E1-E2_ATPase	152..383	CDD:278548	75/252 (30%)
		Cation_ATPase	445..539	CDD:289987	29/117 (25%)
		COG4087	<695..770	CDD:226572	37/74 (50%)
		Cation_ATPase_C	817..1025	CDD:279079	53/214 (25%)
Atp2a2	NP_001104293.1	Cation_ATPase_N	4..72	CDD:279080	17/67 (25%)
		ATPase-IIA1_Ca	53..988	CDD:273452	298/1007 (30%)
		E1-E2_ATPase	93..340	CDD:278548	75/251 (30%)
		Cation_ATPase	419..527	CDD:289987	29/117 (25%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		6/26 (23%)
		HAD	<605..711	CDD:289480	48/128 (38%)
		Cation_ATPase_C	783..986	CDD:279079	53/215 (25%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		7/19 (37%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250\|UniProtKB:O55143	788..1043		55/220 (25%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920