DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp1a4

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001257959.1	Gene:	Atp1a4 / 29132	RGDID:	61952	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1022	Identity:	715/1022 - (69%)
Similarity:	842/1022 - (82%)	Gaps:	4/1022 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKA 86
            ||.:.......:..:..:.|....:|::|::||:|:.:|.||::.:||..::......|||...|
  Rat     9 ATSEQKPRPTLRASNTNRQPKVKRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSVTDA 73

  Fly    87 KENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPAD-DNLYL 150
            :|.|..:|||.||||..||||:||||.|||||::|||.|::|||:||.|..|..:|.|: |||||
  Rat    74 QEILTLNGPNVLTPPPTTPEWIKFCKQLFGGFSLLLWTGSLLCFLAYGIHVSYYQENANKDNLYL 138

  Fly   151 GIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGD 215
            |||||||||:||.||||||:||||||||||.||||.|.|||:|||:.:...|:||||:||||.||
  Rat   139 GIVLSAVVIITGCFSYYQEAKSSKIMESFKTMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGD 203

  Fly   216 RIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCG 280
            ::|||||:|.|:..||||||||||||||||..:.||||||||:|:.|||||.|||||:||||:.|
  Rat   204 QVPADIRVIAAQGCKVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGVVIATG 268

  Fly   281 DHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGI 345
            |||||||||.|.|||..|:||||.||.||||:||.||||||||||.::.||||.|||||||||||
  Rat   269 DHTVMGRIASLTSGLTMGKTPIATEIEHFIHIITAVAVFLGVTFFFLSLILGYTWLDAVIFLIGI 333

  Fly   346 IVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW 410
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||:|
  Rat   334 IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLW 398

  Fly   411 FDNQIIEADTTEDQ-SGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAAL 474
            ||..:.||||:|:| :|..:.::|..:..|:|||.|||||:||..|:.:||.|:..:|||||:||
  Rat   399 FDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASESAL 463

  Fly   475 LKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTI 539
            ||.:|.:...|..:|::|.|:||:|||||||||:|||..|| |...::|:|||||||||:.||:.
  Rat   464 LKFIEQSYSPVSEMRQKNPKVAEIPFNSTNKYQMSIHLLED-NSEAHVLLMKGAPERILDFCSSF 527

  Fly   540 FINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFV 604
            .:||:|..:|||||..|.|||:|||||||||||||...|||: :..||:|||:::|||::||.|.
  Rat   528 LLNGQEYPMDEEMKTDFQNAYIELGGLGERVLGFCFLNLPSN-FSKGFQFNTEELNFPMENLCFA 591

  Fly   605 GLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIP 669
            ||:|||||||.||||||:||||||||||||||||||||||||||||||||.|||.||||.||||.
  Rat   592 GLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEANETAEDIAARLNIS 656

  Fly   670 VSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTG 734
            :|:|:.:..||.||||:||:|:.|.|||.||:.:.|||||||||||||||||||||:||||||||
  Rat   657 ISQVSNKSIKAIVVHGSELKDMDSGQLDNILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTG 721

  Fly   735 DGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 799
            |||||||||||||||:||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat   722 DGVNDSPALKKADIGIAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 786

  Fly   800 SNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVN 864
            ||||||:|||.||:..|||||||:||||||||||||||||||||..|:|||||.||:|..|.|||
  Rat   787 SNIPEITPFLLFIVLSIPLPLGTITILCIDLGTDMVPAISLAYETPESDIMKRLPRNPKTDNLVN 851

  Fly   865 SRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDR 929
            .|||.|||||||||||.||||.||||:|||||.|..|.|||..||...:|||.|:|||:|||..|
  Rat   852 DRLIGMAYGQIGMIQALAGFFTYFVILAENGFKPLDLLGIRLYWDDTNLNDLEDTYGQQWTYEQR 916

  Fly   930 KTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEK 994
            |.:|:||.||||||||:|||||||||||||||:|:|||:|..|.|||:.||:|||.|||.|||:.
  Rat   917 KVVEFTCQTAFFISIVIVQWADLIICKTRRNSLFKQGMKNKVLIFGLLEETILAACLSYIPGMDV 981

  Fly   995 GLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            .|||||||:.|||.|:|:::.||||||.|:..:||.||||||:||||
  Rat   982 ALRMYPLKINWWFCALPYSVLIFIYDEVRKLIIRRRPGGWLEKETYY 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	710/997 (71%)
		Cation_ATPase_N	58..132	CDD:214842	38/73 (52%)
		E1-E2_ATPase	152..383	CDD:278548	181/230 (79%)
		Cation_ATPase	445..539	CDD:289987	54/93 (58%)
		COG4087	<695..770	CDD:226572	66/74 (89%)
		Cation_ATPase_C	817..1025	CDD:279079	150/207 (72%)
Atp1a4	NP_001257959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/26 (15%)
		ATPase-IIC_X-K	32..1028	CDD:273445	710/997 (71%)
		Cation_ATPase_N	46..119	CDD:214842	38/72 (53%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	87..89		1/1 (100%)
		E1-E2_ATPase	140..371	CDD:278548	181/230 (79%)
		Cation_ATPase	434..526	CDD:289987	53/92 (58%)
		COG4087	608..757	CDD:226572	122/148 (82%)
		Cation_ATPase_C	804..1013	CDD:279079	150/208 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	333	1.000	Domainoid score	I1095
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm45302
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.830