Protein Alignment Atpalpha and Atp13a4

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001178587.2
• Gene: Atp13a4 / 288026
• RGDID: 1306927
• Length: 1193
• Species: Rattus norvegicus
• Alignment Length: 1191
• Identity: 239/1191 - (20%)
• Similarity: 418/1191 - (35%)
• Gaps: 391/1191 - (32%)

  Fly    23 TDDDNRTADGQY---KSRRKMPAKVN--KKENLDDLKQELDIDFHKI-SPEELYQRFQTHPENGL 81
            |.|....||.::   ::.||...||.  |.:.:..:...|:..|.|| |.|:.....:.|.:.||
  Rat   105 TPDHPLIADEEFIINRAIRKPDLKVRYIKVQKIRYVWNNLEGQFQKIGSLEDCLSSAKIHQKFGL 169

  Fly    82 SHAKAKENLER--DGPNALTPPKQTPEWVKFCKN------LFGGFAMLLWIGAILCFVAYSIQAS 138
            .....::.:.|  .||||: ..:..|.|....|.      :|..|::.||.
  Rat   170 GLTSEEQEIRRLICGPNAI-DVEIIPIWKLLVKEVLNPFYIFQLFSVCLWF-------------- 219

  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQES-KSSKIMESFKNMVPQFATVIREGEKLTLRAED 202
             ||:..:..|.: |::|.:.|...::...|:| |...::||..::.  .:...|:.....|.:..
  Rat   220 -SEDYKEYALAI-ILMSVISIALTVYDLRQQSVKLHHLVESHNSIT--VSVYERKAGAQDLESRL 280

  Fly   203 LVLGDVVEVKFGDRI--PADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPL-ETKNLAFFS 264
            ||.||:: :..|.|:  |.|..:|:. :..||...|||||.|.::       .|| :|.:.|.:.
  Rat   281 LVPGDLL-ILTGSRVQMPCDAVLIDG-SCVVDEGMLTGESIPVTK-------TPLSQTASSAPWK 336

  Fly   265 TNAVEGTAKGVVISCGDHTVMGRIAG--------LASGLDTGETPIAKEIHH------------- 308
            ..: |...:..::.||...:..:.||        |.:|.:|.:..:.:.|.:
  Rat   337 MQS-EADPRRHILFCGTEVIQAKAAGSGTVRAVVLQTGFNTAKGDLVRSILYPKPMNFKLYRDAI 400

  Fly   309 -FIHLITGVAVFLGVTFFVIAFIL-GYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAS 371
             |:..:.|.|. :|:.:.:..::| |....:.|...:.:|...||..|.|.:|..:....:|:..
  Rat   401 RFLLCLVGTAT-IGMIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKK 464

  Fly   372 KNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGF 436
            |.....:.:.:...|..:.:|.|||||||:..:   .:|   .::..|..             ||
  Rat   465 KGIFCISPQRINVCGQLNLVCFDKTGTLTRGGL---DLW---GVVPCDQN-------------GF 510

  Fly   437 KALSRIATLCNRAEFKGGQDGVPILKKEVSGDASE-----AALLKCMELAL------GDVMNIRK 490
            :|:...|                      ||:|..     ||:..|..|.|      ||.::::.
  Rat   511 QAVHSFA----------------------SGEAVPWGPLCAAMATCHSLILLDGTIQGDPLDLKM 553

  Fly   491 ---------------RNKK------------------------IAEVPFNSTNKYQVSIHETEDT 516
                           .||:                        :.:.||:|..:....|  .::|
  Rat   554 FEATQWEMTVSGDDFHNKEMLAHTMVVKPPDTVGQVPAEGLAILHQFPFSSALQRMTVI--VQET 616

  Fly   517 NDPRYLLVMKGAPERILERCS-----TIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDF 576
            ...| :..|||||||:...|.     |.||:..:....:                |.||:.....
  Rat   617 GGGR-MAFMKGAPERVASFCQPDTVPTTFISELQVYTTQ----------------GFRVIALAYK 664

  Fly   577 MLPSDKYPNGF---KFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDH 638
            .|.:|......   |..:|        |.|:||:.:.:..:......:.:..||.|:..|:|||:
  Rat   665 KLETDCPTTTLMREKVESD--------LIFLGLLILENRLKEETRPVLEELISARIRTAMITGDN 721

  Fly   639 PITAKAIAKSVGIISEG--------NETVEDI------------------AQRLNIPVSEVNPRE 677
            ..||..:|:..|::|||        ||..:..                  :|...|.:.|..|..
  Rat   722 LQTAITVARKSGMVSEGQKVILVEANEATDSSSASITWKLVEEKKHGLFGSQDTYINIREEVPEN 786

  Fly   678 AKAAVVH----GAELRDVS---SDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGD 735
            .:....|    |...:.:|   |..|.:||...|  :|||.||.||..:||..|::...|.:.||
  Rat   787 GREGNYHFALSGKSFQVISQHFSSLLPKILINGT--IFARMSPGQKSSLVEEFQKLDYFVGMCGD 849

  Fly   736 GVNDSPALKKADIGVAMGIAGSDVSKQAADMI---------------LLDDNFASIVT------- 778
            |.||..|||.|.:||::       |:|.|.:.               |:.:..|::||
  Rat   850 GANDCGALKMAHVGVSL-------SEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKY 907

  Fly   779 --------------------GVEEGRLIFDNLKKSIAYTLTSNI----PEISPFL-AFILCDIPL 818
                                .:...:.:|.:|..:....:|.|:    |::.||. |..|...||
  Rat   908 MALYSMIQYVGVLLLYWKTNSLSNYQFLFQDLAITTLIGVTMNLNGANPKLVPFRPAGRLISPPL 972

  Fly   819 PLGTVTILCIDLGTDMV--------PAISLAY------EHAEADIMKRPPRDPFNDK-------- 861
            .|..:..:.:.|...:|        |..|:.|      .:.....:...|..|...:
  Rat   973 LLSVILNILLSLAMHIVGFILVQKQPWYSMDYHSVCPVRNESVSALSASPNVPEKTRSNSTFASF 1037

  Fly   862 ---------LVNSRLISMAYGQ----------------IGMIQAAAGFF---------------- 885
                     .:|..::::.:.:                :.::|.....|
  Rat  1038 ENTTIWFLGTINCIVVALVFSKGKPFRQPTYTNYIFVLVLILQMGVCLFILFADIPELHRRLDLL 1102

  Fly   886 -------VYFVIMAENGFL------------------PKKLFGIR-----KMWDSKAVNDLTDSY 920
                   ||.:||..:.|:                  .|:.||..     ::|..   |..|||
  Rat  1103 CTPVLWRVYILIMVSSNFVVSLAVEKAIIENRALWTAVKRCFGYHSKSQYRVWQR---NLATDS- 1163

  Fly   921 GQEW------TYRDRKTLEYT 935
              .|      :|.|.:.:.|:
  Rat  1164 --SWPPLNQTSYSDMQGVSYS 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	231/1166 (20%)
Atp13a4	NP_001178587.2	P5-ATPase	17..142	CDD:463565	9/36 (25%)
		P-type_ATPase_cation	174..1000	CDD:319842	197/932 (21%)