Protein Alignment Atpalpha and Atp1a4

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_038762.1
• Gene: Atp1a4 / 27222
• MGIID: 1351335
• Length: 1032
• Species: Mus musculus
• Alignment Length: 1005
• Identity: 717/1005 - (71%)
• Similarity: 843/1005 - (83%)
• Gaps: 4/1005 - (0%)

  Fly    39 KMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQ 103
            :.|....:|::|::||:|:.:|.||::.:||..::......|||..:|::.|.::|||.||||..
Mouse    30 RQPKMKRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTPPPT 94

  Fly   104 TPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPAD-DNLYLGIVLSAVVIVTGIFSYY 167
            ||||||||:.|||||::|||.||.|||:||.|..:..:|.|: ||||||||||||||:||.||||
Mouse    95 TPEWVKFCRQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITGCFSYY 159

  Fly   168 QESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVD 232
            ||:|||||||||||||||.|.|||:|||:.:...|:||||:||||.||:||||||:|.|:..|||
Mouse   160 QEAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISAQGCKVD 224

  Fly   233 NSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDT 297
            |||||||||||||..:.||||||||:|:.|||||.|||||:|:||:.||:|||||||.|.|||..
Mouse   225 NSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGIVIATGDYTVMGRIASLTSGLQM 289

  Fly   298 GETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCL 362
            |:||||.||.|||||||.|||||||:||.::.||||.||||||||||||||||||||||||||||
Mouse   290 GKTPIATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFLIGIIVANVPEGLLATVTVCL 354

  Fly   363 TLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQ-SG 426
            ||||||||.|||||||||||||||||||||||||||||||||||||:|||..:.||||:|:| :|
Mouse   355 TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTG 419

  Fly   427 VQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKR 491
            ..:.::|..:..|:|||.|||||:||..|:.|||.|:..:|||||:||||.:|.:...|..:|::
Mouse   420 KTFPKSSDTWFYLARIAGLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQSYNPVSEMRQK 484

  Fly   492 NKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAF 556
            |.|:||:|||||||||:|||..|| |...::|:||||||||.:.||:..:||:|..:|||||..|
Mouse   485 NPKVAEIPFNSTNKYQMSIHLLED-NSEAHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDF 548

  Fly   557 NNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAV 621
            .|||:|||||||||||||...|||: :..||:||||::|||::||.|.||:|||||||.||||||
Mouse   549 QNAYIELGGLGERVLGFCFLNLPSN-FSKGFQFNTDELNFPMENLCFAGLISMIDPPRTAVPDAV 612

  Fly   622 AKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGA 686
            :||||||||||||||||||||||||||||||||||:|.||||.|||||:|:||.:..||.||||:
Mouse   613 SKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGS 677

  Fly   687 ELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVA 751
            ||:|:.|.|||:||:.:.|||||||||||||||||||||:|||||||||||||||||||||||:|
Mouse   678 ELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIA 742

  Fly   752 MGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDI 816
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||:..|
Mouse   743 MGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIILSI 807

  Fly   817 PLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAA 881
            ||||||:||||||||||||||||||||..|:|||||.||:|..|.|||:|||.|||||||||||.
Mouse   808 PLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNNRLIGMAYGQIGMIQAL 872

  Fly   882 AGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVV 946
            ||||.||||:|||||.|..|.|||..||...:|||.|||||:|||..||.:|:||.||||||||:
Mouse   873 AGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTCQTAFFISIVI 937

  Fly   947 VQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIP 1011
            |||||||||||||||:|:|||:|..|.|||:.||||||||||.|||:..|||||||:.|||.|:|
Mouse   938 VQWADLIICKTRRNSLFKQGMKNKILIFGLLEETVLAAFLSYVPGMDVSLRMYPLKINWWFCALP 1002

  Fly  1012 FALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            :::.||:|||.|:..:||.||||||:||||
Mouse  1003 YSVLIFVYDEIRKLIIRRRPGGWLEKETYY 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	714/997 (72%)
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		2/11 (18%)
		ATPase-IIC_X-K	36..1032	CDD:273445	714/997 (72%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93		1/1 (100%)