DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and pmr1

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_595098.1	Gene:	pmr1 / 2540383	PomBaseID:	SPBC31E1.02c	Length:	899	Species:	Schizosaccharomyces pombe

Alignment Length:	1011	Identity:	304/1011 - (30%)
Similarity:	483/1011 - (47%)	Gaps:	143/1011 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERD---GPNALTPPKQTPEWVKFCKN----- 113
            :.:.:...|.|:.....:|...||||  ..:|...|:   |.|.|....:....|:|.|.
pombe     1 MSVQYDAFSVEQTCADLETDMYNGLS--SLQEITRRNKVHGDNDLKVEDEENMVVQFLKQFVKDP 63

  Fly   114 ----LFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSK 174
                ||...|:.:.:|.|                 ||  .:.|.|:.|::||  ..:.||.:|.:
pombe    64 LILLLFASSAISVTLGNI-----------------DD--AISIALAIVIVVT--VGFVQEYRSEQ 107

  Fly   175 IMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGE 239
            .:::..|:||.:..|||.|:...:.|..||.||:|.::.|||:|||:||:||...::|.|:||||
pombe   108 SLKALNNLVPHYCNVIRSGKTEHIVASKLVPGDLVILQIGDRVPADLRIVEATELEIDESNLTGE 172

  Fly   240 SEPQSRGAEFTHEN--PLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPI 302
            :.|:.:.:|....|  ..|..|:||..|....|..:|:|::.|..|..||:.......:..:||:
pombe   173 NSPRKKSSEAISSNISLTERNNIAFMGTLVRHGHGRGIVVATGSDTEFGRVFLTMQQTEKPKTPL 237

  Fly   303 AKEIH------HFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVC 361
            ...:.      ..|.|| |:||.:     ::.|..|.:||:.:...:.:.||.:||||...|||.
pombe   238 QNSMDDLGKQLSLISLI-GIAVIV-----LVGFFQGKNWLEMLTIGVSLAVAAIPEGLPIIVTVT 296

  Fly   362 LTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSG 426
            |.|...||:.|..:::.|.:||||||.:.||||||||||.|.|||..::....:......|.:..
pombe   297 LALGVLRMSKKRAIIRRLPSVETLGSVNVICSDKTGTLTMNHMTVTKIYTCGMLAAFSLPESEHI 361

  Fly   427 VQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCME-LALGDVMNIRK 490
            ....|.:.|.:.....|.|||.::.....|.:.......:|...:.||::|.| ..|.|.   |:
pombe   362 ELSVRRTVGIEKALLAAALCNNSKVHNKADSILDTTCPWAGFPVDVALIECSERFGLKDP---RE 423

  Fly   491 RNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIF-INGKEKVLDEEMKE 554
            ...:|:||.|:|..|| :|:....:::...:   ||||.|::|..|:... .:|.:..|..||||
pombe   424 TYSRISEVSFSSERKY-MSVAVQYNSSKMNF---MKGATEQVLSSCAYFSDQDGVQHELTAEMKE 484

  Fly   555 AFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPD 619
            .......|:...|.|::...          :|...|         .|.|.||..:.||||..|.:
pombe   485 NIQRNEFEMAASGLRIIAVA----------SGINTN---------KLVFHGLFGINDPPRPQVRE 530

  Fly   620 AVAKCRSAGIKVIMVTGDHPITAKAIAKSVG--IISEGNETVEDIAQRLNIPVSEVNPREAKAAV 682
            :|....:.|::|||:|||..:||.:||:|:|  |.|...|.:.:.|
pombe   531 SVQYLMTGGVRVIMITGDSVVTAISIARSLGMAIPSNDEEAIRNYA------------------- 576

  Fly   683 VHGAELRDVSSDQL-DEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKA 746
            :.||:|.|:.|..| |.:.|.   :|||||:||.|:.|||..|.:|.:||:|||||||:||||.|
pombe   577 LTGAQLDDLDSSSLRDAVSRV---VVFARTTPQHKMKIVEALQSLGDVVAMTGDGVNDAPALKLA 638

  Fly   747 DIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF 811
            |||:|||..|:||:|:||||||.||:||:|::.||||:.||:|:|..|.:.|::::..:|.....
pombe   639 DIGIAMGRQGTDVAKEAADMILTDDSFATILSAVEEGKGIFNNIKNFITFQLSTSVAALSLIAIS 703

  Fly   812 ILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIG 876
            .:.....||..:.||.|::..|..||.||..|..:.|:|.:||| |.|..:::.:|:........
pombe   704 SVFGFQNPLNAMQILWINILMDGPPAQSLGVESVDEDVMMKPPR-PRNAPIISVQLLQRVLLSAF 767

  Fly   877 MIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFF 941
            :|....  .|.|.:..::|.:                           |.|| .|:.:||...|
pombe   768 IIVTVT--IVVFRVQMQDGNV---------------------------TARD-TTMTFTCFVFF- 801

  Fly   942 ISIVVVQWADLIICKTRRNSIFQQGM-RNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVW 1005
                  ...:.:.|::...|:|:.|: .|...|..:....:..|.:.|....::..:...:.|..
pombe   802 ------DMFNALACRSETKSVFKLGIFSNRMFNIAVGGSLIGQALVVYASPFQRIFQTEAIGLKD 860

  Fly  1006 WFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ....:....::...||.|::|.||.  |.:..::.|
pombe   861 VLILLACTSSVLWVDEIRKWYRRRK--GLVRTKSNY 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	303/1009 (30%)
		Cation_ATPase_N	58..132	CDD:214842	20/85 (24%)
		E1-E2_ATPase	152..383	CDD:278548	79/238 (33%)
		Cation_ATPase	445..539	CDD:289987	27/94 (29%)
		COG4087	<695..770	CDD:226572	46/75 (61%)
		Cation_ATPase_C	817..1025	CDD:279079	42/208 (20%)
pmr1	NP_595098.1	ATPase-IIA2_Ca	2..886	CDD:130585	302/1000 (30%)
		Cation_ATPase_N	5..75	CDD:279080	18/71 (25%)
		E1-E2_ATPase	87..318	CDD:278548	79/238 (33%)
		Cation_ATPase	380..467	CDD:289987	27/93 (29%)
		COG4087	<599..671	CDD:226572	48/71 (68%)
		Cation_ATPase_C	711..880	CDD:279079	42/206 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920