DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp2a3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_038941199.1	Gene:	Atp2a3 / 25391	RGDID:	2175	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	316/1080 - (29%)
Similarity:	497/1080 - (46%)	Gaps:	198/1080 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGA 126
            |.:|..::.:||....|.||:..:..:..||.|||.|...:....|....:........:|.:.|
  Rat     5 HLLSAADVLRRFSVTAEGGLTLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAA 69

  Fly   127 ILCFVAYSIQ-----ASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQF 186
            ::.||....:     .:...||        :|:..:::...|...:||..:...:|:.|...|:.
  Rat    70 LVSFVLAWFEEGEETTTAFVEP--------LVIMLILVANAIVGVWQERNAESAIEALKEYEPEM 126

  Fly   187 ATVIREGEK--LTLRAEDLVLGDVVEVKFGDRIPADIRIIEARN--FKVDNSSLTGESEPQSRGA 247
            ..|||...|  ..:||.|:|.||:|||..||::|||:|:||.::  .:||.|.|||||...::
  Rat   127 GKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTK-- 189

  Fly   248 EFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAK 304
               |.:.:        :.||:.|..||...|.|.||.::.|.||.:|:|....:.::...||:.:
  Rat   190 ---HTDAIPDPRAVNQDKKNMLFSGTNIASGKALGVAVATGLHTELGKIRSQMAAVEPERTPLQR 251

  Fly   305 EIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATVT 359
            ::..|...::.....:.|..:||..      ..|..||...::    .:.:.||.:||||.|.:|
  Rat   252 KLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVIT 316

  Fly   360 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEAD----- 419
            .||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:.   :.||:
  Rat   317 TCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEAEAGACR 378

  Fly   420 --------TT-----EDQSGVQYDRTS--PGFKALSRIATLCNRA-----EFKGGQDGVPILKKE 464
                    ||     |.:.|.|..|..  .|...|:.|..|||.:     |.||..:.|
  Rat   379 LHEFTISGTTYTPEGEVRQGEQLVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKV------ 437

  Fly   465 VSGDASEAALLKCMELALGDVMN---------------------IRKRNKKIAEVPFNSTNKYQV 508
              |:|:|.||     ..|.:.||                     |::..:|...:.| |.::..:
  Rat   438 --GEATETAL-----TCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEF-SRDRKSM 494

  Fly   509 SIHETEDTNDPR---YLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERV 570
            |::.|....||:   ..:.:|||||.::||||::.:..:...|....:|.. .|.:...|.|...
  Rat   495 SVYCTPTRADPKAQGSKMFVKGAPESVIERCSSVRVGSRTVPLSATSREHI-LAKIRDWGSGSDT 558

  Fly   571 LGFCDFMLPSDKYPNGFKFNTDDINFPID---NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVI 632
            |. |..:...|..|.......||.:..:.   .|.|||.:.|:||||..|...:.:|..|||:|:
  Rat   559 LR-CLALATRDTPPRKEDMQLDDCSQFVQYETGLTFVGCVGMLDPPRPEVAACITRCSRAGIRVV 622

  Fly   633 MVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLD 697
            |:|||:..||.||.:.:||..:    .||:.              .||..  |.|..|:|.:|..
  Rat   623 MITGDNKGTAVAICRRLGIFGD----TEDVL--------------GKAYT--GREFDDLSPEQQR 667

  Fly   698 EILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQ 762
            :..|  |...|||..|..|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.
  Rat   668 QACR--TARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKS 729

  Fly   763 AADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILC 827
            ||:|:|.||||||||..|||||.|::|:|:.|.|.::||:.|:.......:..:|..|..|.:|.
  Rat   730 AAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLW 794

  Fly   828 IDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGM------IQAAAGFFV 886
            ::|.||.:||.:|.:...:.|||::.||:| .:.|::..|. ..|..||:      :.||..:|:
  Rat   795 VNLVTDGLPATALGFNPPDLDIMEKLPRNP-REALISGWLF-FRYLAIGVYVGLATVAAATWWFL 857

  Fly   887 YFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYR------------------DRKTLE 933
            |                              |:.|.:.|:.                  |.:..|
  Rat   858 Y------------------------------DAEGPQVTFHQLRNFLKCSEDNPLFAGIDCEVFE 892

  Fly   934 YTCHTAFFISIVV-VQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSY----CPGME 993
            ....|...:|::| ::..:.:...:...|:.:  |..| ||..|:...|::..|.:    .|.:.
  Rat   893 SRFPTTMALSVLVTIEMCNALNSVSENQSLLR--MPPW-LNPWLLGAVVMSMALHFLILLVPPLP 954

  Fly   994 KGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGG 1033
            ...::.||....|...:..:|.:.:.||..::..|.:..|
  Rat   955 LIFQVTPLSGRQWGVVLQMSLPVILLDEALKYLSRHHVDG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	316/1080 (29%)
		Cation_ATPase_N	58..132	CDD:214842	17/69 (25%)
		E1-E2_ATPase	152..383	CDD:278548	78/252 (31%)
		Cation_ATPase	445..539	CDD:289987	32/122 (26%)
		COG4087	<695..770	CDD:226572	39/74 (53%)
		Cation_ATPase_C	817..1025	CDD:279079	48/236 (20%)
Atp2a3	XP_038941199.1	P-type_ATPase_SERCA	5..989	CDD:319778	314/1073 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920