DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp4a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_036641.1	Gene:	Atp4a / 24216	RGDID:	2177	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	627/1040 - (60%)
Similarity:	781/1040 - (75%)	Gaps:	15/1040 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRADSYRVATV-IATDDDNRTADGQYKSRRKMPAKV------NKKENLDDLKQELDIDFHKISPE 67
            |:|::|.:.:| :.|......|       .||..|.      .|||.|:::|:|::::.|::|..
  Rat     2 GKAENYELYSVELGTGPGGNMA-------AKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVS 59

  Fly    68 ELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVA 132
            ||.|::||....||..:.|.|.|.|||||||.||:.|||:|||.:.|.||...|:|:.|.:|.:|
  Rat    60 ELEQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIA 124

  Fly   133 YSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLT 197
            ::||||..:...||||||.:.|.|||:|||.|.||||.||:.|:.||||:|||.|||||:|:|..
  Rat   125 FAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQ 189

  Fly   198 LRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAF 262
            :.|:.||:||:||:|.|||:||||||:.|:..||||||||||||||:|..|.|||:||||:|:||
  Rat   190 INADQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAF 254

  Fly   263 FSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVI 327
            |||..:||||:|:|:|.||.|::||||.||||::..:||||.||.||:.:|.|:|:..|.||||:
  Rat   255 FSTMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVV 319

  Fly   328 AFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTIC 392
            |..:||.:|.|::|.:.|:||.|||||||||||||:|||||:|||||:||||||||||||||.||
  Rat   320 AMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVIC 384

  Fly   393 SDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDG 457
            ||||||||||||||:|:||||.|..|||||||||..:|::|..::||.|:.||||||.||.|||.
  Rat   385 SDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDA 449

  Fly   458 VPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYL 522
            ||:.|:.|.|||||.||||..||.||:.|..|.|..|:.|:|||||||:|:|||..||..|||:|
  Rat   450 VPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHL 514

  Fly   523 LVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGF 587
            |||||||||:|||||:|.|.|:|..|||:.:|||..||:.||||||||||||...|....||.|:
  Rat   515 LVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGY 579

  Fly   588 KFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGII 652
            .|:.:.:|||...|.|.||:||||||||.|||||.|||:|||:||||||||||||||||.|||||
  Rat   580 TFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGII 644

  Fly   653 SEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKL 717
            |||:|||||||.||.:||.:||.::|:|.|::|.:|:|:...:|.|.||.|.|:|||||||||||
  Rat   645 SEGSETVEDIAARLRMPVDQVNKKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKL 709

  Fly   718 IIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEE 782
            :|||.|||:||||||||||||||||||||||||||||||||.:|.|||||||||||||||||||:
  Rat   710 VIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQ 774

  Fly   783 GRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEA 847
            |||||||||||||||||.||||::|:|.:|...:|||||.:|||.|:|.||:.|::|||||.||:
  Rat   775 GRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES 839

  Fly   848 DIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKA 912
            |||...||:|..|:|||..|.:.:|.|||.||:.|||..||..||:.|:.|....|:|..|:...
  Rat   840 DIMHLRPRNPRRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHH 904

  Fly   913 VNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQG-MRNWALNFGL 976
            :.||.||||||||:..|...:|||:|.|||||.:.|.||::|.||||.|.|||| .||..|...:
  Rat   905 LQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAI 969

  Fly   977 VFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||:..:..||.|||||.......|::..||...:||.|.||:|||.|:..:|..||.|.:||.||
  Rat   970 VFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY 1034

Fly 1042 1041
Rat 1035 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	616/996 (62%)
		Cation_ATPase_N	58..132	CDD:214842	34/73 (47%)
		E1-E2_ATPase	152..383	CDD:278548	148/230 (64%)
		Cation_ATPase	445..539	CDD:289987	63/93 (68%)
		COG4087	<695..770	CDD:226572	62/74 (84%)
		Cation_ATPase_C	817..1025	CDD:279079	106/208 (51%)
Atp4a	NP_036641.1	H-K_ATPase_N	2..>27	CDD:286172	7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40		6/31 (19%)
		ATPase-IIC_X-K	42..1034	CDD:273445	613/991 (62%)
		Cation_ATPase_N	50..124	CDD:214842	34/73 (47%)
		E1-E2_ATPase	145..375	CDD:278548	148/229 (65%)
		Cation_ATPase	437..531	CDD:289987	63/93 (68%)
		COG4087	<687..>742	CDD:226572	45/54 (83%)
		Cation_ATPase_C	809..1018	CDD:279079	106/208 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830