DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp1a1

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_036636.1	Gene:	Atp1a1 / 24211	RGDID:	2167	Length:	1023	Species:	Rattus norvegicus

Alignment Length:	1032	Identity:	766/1032 - (74%)
Similarity:	893/1032 - (86%)	Gaps:	14/1032 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74
            || |.|..|.|        :..|..||:     |..|:.::|:||:|:.:|.||:|.:||::::.
  Rat     6 GR-DKYEPAAV--------SEHGDKKSK-----KAKKERDMDELKKEVSMDDHKLSLDELHRKYG 56

  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139
            |....||:.|:|.|.|.||||||||||..||||||||:.|||||:|||||||||||:||.|:::|
  Rat    57 TDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSAT 121

  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204
            .|||.:|:||||:|||||||:||.||||||:|||||||||||||||.|.|||.|||:::.|||:|
  Rat   122 EEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVV 186

  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269
            :||:||||.|||||||:|||.|...||||||||||||||:|..:||:||||||:|:||||||.||
  Rat   187 VGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVE 251

  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334
            |||:|:|:..||.|||||||.|||||:.|:||||:||.|||||||||||||||:||:::.||.|.
  Rat   252 GTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYT 316

  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399
            ||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
  Rat   317 WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 381

  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464
            ||||||||||||||||.||||||:||||.:|:||..:.||||||.|||||.|:..|:.:||||:.
  Rat   382 TQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRA 446

  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529
            |:|||||:|||||:|:..|.||.:|::..||.|:|||||||||:|||:..:.::|::||||||||
  Rat   447 VAGDASESALLKCIEVCCGSVMEMREKYTKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMKGAP 511

  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594
            ||||:|||:|.::|||:.||||:|:||.|||:|||||||||||||..:||.:::|.||:|:||::
  Rat   512 ERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEV 576

  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659
            |||:|||.||||:||||||||||||||.|||||||||||||||||||||||||.|||||||||||
  Rat   577 NFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETV 641

  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724
            ||||.||||||::||||:|||.||||::|:|::|::||:||||||||||||||||||||||||||
  Rat   642 EDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQ 706

  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789
            |.||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Rat   707 RQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 771

  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854
            ||||||||||||||||:|||.||:.:||||||||||||||||||||||||||||.||:|||||.|
  Rat   772 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP 836

  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919
            |:|..|||||.|||||||||||||||..|||.||||:|||||||..|.|||:.||.:.:||:.||
  Rat   837 RNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVEDS 901

  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAA 984
            |||:|||..||.:|:|||||||:||||||||||:||||||||:|||||:|..|.|||..||.|||
  Rat   902 YGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAA 966

  Fly   985 FLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||||||||...|||||||..|||.|.|::|.||:|||.|:..:||.||||:|:||||
  Rat   967 FLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	754/995 (76%)
		Cation_ATPase_N	58..132	CDD:214842	47/73 (64%)
		E1-E2_ATPase	152..383	CDD:278548	181/230 (79%)
		Cation_ATPase	445..539	CDD:289987	58/93 (62%)
		COG4087	<695..770	CDD:226572	70/74 (95%)
		Cation_ATPase_C	817..1025	CDD:279079	157/207 (76%)
Atp1a1	NP_036636.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		14/45 (31%)
		ATPase-IIC_X-K	29..1023	CDD:273445	753/993 (76%)
		Cation_ATPase_N	40..114	CDD:214842	47/73 (64%)
		Phosphoinositide-3 kinase binding	82..84		1/1 (100%)
		E1-E2_ATPase	134..365	CDD:278548	181/230 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..235		13/18 (72%)
		Cation_ATPase	427..521	CDD:289987	58/93 (62%)
		COG4087	606..>732	CDD:226572	110/125 (88%)
		Cation_ATPase_C	799..1008	CDD:279079	157/208 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	472	1.000	Domainoid score	I423
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1566	1.000	Inparanoid score	I82
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D50082at33208
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm45302
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840