DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and ATP13A2

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_005245867.1	Gene:	ATP13A2 / 23400	HGNCID:	30213	Length:	1201	Species:	Homo sapiens

Alignment Length:	1006	Identity:	221/1006 - (21%)
Similarity:	382/1006 - (37%)	Gaps:	208/1006 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RSDYEHGRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPE- 67
            :|..|.||:.    |.|.|      ..:|.:|.    .|:::|.|....:.|.: :.::....:
Human   122 QSQAEDGRSQ----AAVGA------VPEGAWKD----TAQLHKSEEAVSVGQRV-LRYYLFQGQR 171

  Fly    68 ----ELYQRFQTHPENGLSHAKAKENLERD----------------GPNALT-PPKQTPE-WVKF 110
                |..|.|  :..:.|.|.::.:::.|.                |||.:: |.|..|: .|..
Human   172 YIWIETQQAF--YQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDE 234

  Fly   111 CKNLFGG---FAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKS 172
            ..|.:.|   |::.||:                   ||...:..:.:..:..::...|.|:..|.
Human   235 ALNPYYGFQAFSIALWL-------------------ADHYYWYALCIFLISSISICLSLYKTRKQ 280

  Fly   173 SKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGD-VVEVKFGDRIPADIRIIEARNFKVDNSSL 236
            |:.:.....:..:.......||:..:.:.:||.|| :|..:.|..:|.|..:: |....|:.|||
Human   281 SQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALV-AGECMVNESSL 344

  Fly   237 TGESEPQSRGA---------EFTHENPLETKNLAFFSTNAVEGTA------KGVVISCGDHTVMG 286
            ||||.|..:.|         ..||.     ::..|..|..::..|      ..||...|..|..|
Human   345 TGESIPVLKTALPEGLGPYCAETHR-----RHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKG 404

  Fly   287 RIAGLASGLDTGETPI-AKEIHHFIHLITGVAV--FLGVTFFVIAFILGYHWL---DAVIFLIGI 345
               ||.|.: ....|| .|...|.:..:..::|  .||..:.:  |||..:.:   :.||..:.:
Human   405 ---GLVSSI-LHPRPINFKFYKHSMKFVAALSVLALLGTIYSI--FILYRNRVPLNEIVIRALDL 463

  Fly   346 IVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW 410
            :...||..|.|.:|||......|:..:.....:...:...|....:|.|||||||::.:.|.
Human   464 VTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVM--- 525

  Fly   411 FDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVP-----------ILKKE 464
               .::..........|...|..|....|..:||....:..:....|.|           :|::|
Human   526 ---GVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEE 587

  Fly   465 VSGDASEAA-------------LLKCMELALGDVMNIRKRNKKIAEVPFNST-NKYQVSIHETED 515
            .:.|::...             .|:.||.....|..:.:       .||:|. .:..|.:.....
Human   588 PAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHR-------FPFSSALQRMSVVVAWPGA 645

  Fly   516 TNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPS 580
            |....|   :||:||.:...|:           .|.:...|..........|.||:......||:
Human   646 TQPEAY---VKGSPELVAGLCN-----------PETVPTDFAQMLQSYTAAGYRVVALASKPLPT 696

  Fly   581 DKYPN---GFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITA 642
              .|:   ..:...|.:...:..|..:.:.:::.|....|..|:.:.|   |:.:|||||:..||
Human   697 --VPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTR---IRAVMVTGDNLQTA 756

  Fly   643 KAIAKSVGIIS--EGNETVEDIAQRLNIPVS-EVNPREAKAAVVHGAELRDVSSDQLDE------ 698
            ..:|:..|:::  |....|.........|.| |..|.|:..| |:|.:..|.::....|
Human   757 VTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTA-VNGVKDPDQAASYTVEPDPRSR 820

  Fly   699 -----------ILRYHTEI---------VFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPAL 743
                       |:::..::         ||||.:|:||..:|...|::...|.:.|||.||..||
Human   821 HLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGAL 885

  Fly   744 KKADIGVAMGIA-GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN----LKKSIAYTLTSNIP 803
            |.||:|:::..| .|.||...:.|..::    .:...:.|||...|.    .|....|:||..|.
Human   886 KAADVGISLSQAEASVVSPFTSSMASIE----CVPMVIREGRCSLDTSFSVFKYMALYSLTQFIS 946

  Fly   804 EISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMK-RPPRDPFNDKLVNSRL 867
                  ..||..|...||.:..|.|||......|:.::.......:.: |||....:..:::|.|
Human   947 ------VLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLL 1005

  Fly   868 ISMAYGQIGMIQAAAGFFVYFVIMAENGFLP 898
            :.|..  :..:|...    ||:.:|:..|:|
Human  1006 LQMVL--VTGVQLGG----YFLTLAQPWFVP 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	211/965 (22%)
		Cation_ATPase_N	58..132	CDD:214842	18/99 (18%)
		E1-E2_ATPase	152..383	CDD:278548	58/252 (23%)
		Cation_ATPase	445..539	CDD:289987	20/118 (17%)
		COG4087	<695..770	CDD:226572	28/101 (28%)
		Cation_ATPase_C	817..1025	CDD:279079	19/83 (23%)
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	221/1006 (22%)
		P5-ATPase	39..>114	CDD:289194
		E1-E2_ATPase	262..497	CDD:278548	58/246 (24%)
		Cation_ATPase	<627..663	CDD:289987	10/38 (26%)
		COG4087	<849..>898	CDD:226572	21/48 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910