DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp12a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_619593.2	Gene:	Atp12a / 192113	MGIID:	1926943	Length:	1035	Species:	Mus musculus

Alignment Length:	1012	Identity:	649/1012 - (64%)
Similarity:	801/1012 - (79%)	Gaps:	3/1012 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGP 95
            |.::|..:...::.||.:. ::||:|||:|.|::|..:|.|::.|:...|||..:|.|.|.||||
Mouse    26 DKKFKGGKNKDSEPNKSQE-EELKKELDLDDHRLSNTDLEQKYGTNIIQGLSSIRAAELLARDGP 89

  Fly    96 NALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIV 160
            |||||||||||.:||.|.:.|||::||||||.||::||.|| ..|...:.||:|||.:|..|||:
Mouse    90 NALTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQ-YVSSTASLDNVYLGAILVLVVIL 153

  Fly   161 TGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIE 225
            ||||:||||:||:.||.||..|:||.|.|||:.||..:.||.||:|||||:|.||:||||||::.
Mouse   154 TGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQIPADIRLVF 218

  Fly   226 ARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAG 290
            ::..||||||||||||||:|..||||||||||||:.|:||..:||||.|:||:.||.|::||||.
Mouse   219 SQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIAS 283

  Fly   291 LASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLL 355
            ||||:.:.:||||.||.||:|::..|||.:||.||:.|..:.|:.|||:||||.|||||||||||
Mouse   284 LASGVGSEKTPIAIEIEHFVHIVAAVAVSVGVIFFITAVCMKYYVLDAIIFLISIIVANVPEGLL 348

  Fly   356 ATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADT 420
            |||||.|:|||||||.||||||||||||||||||.||||||||||||||||||:||||||..|||
Mouse   349 ATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADT 413

  Fly   421 TEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDV 485
            :|:|:...:|::|..:.:||:|.||||||||:.||:.|||:|:.|.|||||.||||..|:.||||
Mouse   414 SENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRVVVGDASETALLKFSEVILGDV 478

  Fly   486 MNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDE 550
            |:|||||.|:||:|||||||:|:|||||||.||.|:|:|||||||||||:||||.|||:|:.||:
Mouse   479 MDIRKRNHKVAEIPFNSTNKFQLSIHETEDPNDKRFLMVMKGAPERILEKCSTIMINGQEQPLDK 543

  Fly   551 EMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRA 615
            ...:||:.||||||||||||||||...||:||:|..:.|:.|.||||..||.||||:|||||||:
Mouse   544 SSADAFHTAYMELGGLGERVLGFCHLYLPADKFPQSYTFDVDSINFPTSNLCFVGLLSMIDPPRS 608

  Fly   616 AVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKA 680
            .|||||:|||||||||||||||||||||||||||||||..||||||||:|.||.|.:||.|||||
Mouse   609 TVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKA 673

  Fly   681 AVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKK 745
            |||.|.||:|::.:||||:|..:.|||||||||||||||||||||..|:||||||||||||||||
Mouse   674 AVVTGMELKDMTPEQLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKK 738

  Fly   746 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLA 810
            ||||:||||||||.:|.||||:|||||||||||||||||||||||||:||||||.||.|:.|||.
Mouse   739 ADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLI 803

  Fly   811 FILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQI 875
            :|:..:|||:||:|||.||||||::|:|:||||.||:|||.|.||....|:|||.:|...:|..|
Mouse   804 YIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNKQLAIYSYLHI 868

  Fly   876 GMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAF 940
            |::||..||.|||.:.|:.||.|..|..:|..|::..:|||.||||||||...||.||:|..|||
Mouse   869 GLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAF 933

  Fly   941 FISIVVVQWADLIICKTRRNSIFQQGM-RNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLV 1004
            |::|:|.|.|||||.|||||||||||: ||..:..|::.:.::|..|||..|....|....|:..
Mouse   934 FVAIMVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIISQIIVALVLSYGLGSVTALSFTMLRAQ 998

  Fly  1005 WWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            :||.|:|.|:.|::|||.|:.::|..||.|.::..||
Mouse   999 YWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	645/996 (65%)
		Cation_ATPase_N	58..132	CDD:214842	42/73 (58%)
		E1-E2_ATPase	152..383	CDD:278548	152/230 (66%)
		Cation_ATPase	445..539	CDD:289987	69/93 (74%)
		COG4087	<695..770	CDD:226572	61/74 (82%)
		Cation_ATPase_C	817..1025	CDD:279079	109/208 (52%)
Atp12a	NP_619593.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..49		5/23 (22%)
Atp12a	NP_619593.2	ATPase-IIC_X-K	40..1035	CDD:273445	645/996 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.830