DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and catp-2

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_504328.1	Gene:	catp-2 / 182114	WormBaseID:	WBGene00015338	Length:	1050	Species:	Caenorhabditis elegans

Alignment Length:	1056	Identity:	381/1056 - (36%)
Similarity:	573/1056 - (54%)	Gaps:	103/1056 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 AKVNKKENLDDLKQELDIDF--HKISPEELYQRFQ------THPE--NGLSHAKAKENLERDGPN 96
            |..:|:.|    :|.|.:.|  |.:...:|.::|.      ..|:  .|||...|.|.||.||.|
Worm    22 ADASKEVN----QQNLSLSFNEHHLDMRQLSEKFSMSKLDIVDPKVSRGLSKQVAAERLESDGRN 82

  Fly    97 ALTPPKQTPEWVKFCKNLFGGFAMLLWI----GAILCFVAYSIQASTSEEPAD-DNLYLGIVLSA 156
            ||:|||....|..|.:.    |..||||    .|.|..|||..      :|:| .||.:||.:..
Worm    83 ALSPPKVISNWKLFLRQ----FKNLLWILMFGAAALSLVAYIY------DPSDLTNLCVGIFIIV 137

  Fly   157 VVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADI 221
            ::.|..|.|:::|.|..:::.:|::::|....|||:|.:.||..|:||:||:|.|:.|.::||||
Worm   138 IIFVMCIVSFFEEKKGVEVVRAFQSLMPLSCQVIRDGVEQTLNPEELVVGDIVVVRSGCKVPADI 202

  Fly   222 RIIEARNFKVDNSSLTGESEPQSRGAEFTHENP--LETKNLAFFSTNAVEGTAKGVVISCGDHTV 284
            |:|...:|.::.||:|||:||....:....:..  .|:.|:||..:..|:|...|:||..|:.||
Worm   203 RVIACTDFYLETSSITGEAEPLEFNSAMADQKTSIFESYNIAFNGSFCVDGEGYGIVIRTGERTV 267

  Fly   285 MGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVI--FLIG--- 344
            :|:||.:.......:.....||..|:..||.:|:.:.|..|.:.  ||.:....||  |:.|
Worm   268 IGQIASMTLDQKEQKCKFQVEIGRFVKFITVMAIIMAVIIFSVG--LGINKGHDVIRYFVTGFLM 330

  Fly   345 IIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHM 409
            :|:||||:||..|||..||:.|:|||.||..:|.||.::::|:|:.|.||||||||:|.|||..:
Worm   331 VIIANVPQGLPTTVTTELTIIARRMAKKNVFLKKLEKIDSVGATTLIASDKTGTLTKNCMTVTDL 395

  Fly   410 WFDNQIIEA--DTTEDQSGVQYDRTS---PGFKA----LSRIATLCNRAEFKG---------GQD 456
            |::|.....  :.....:..::..||   ..|.|    |..:..:||:|..:.         ..|
Worm   396 WYNNSYNSGRPENRRRSTKTRFSITSNPAQSFDAPLSDLLSVVCVCNKARIENTVTVNRPPPNVD 460

  Fly   457 G---------VPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSI-- 510
            .         .|:.:..:.|:.||.|||:... |:.|...:|:..:.:.|:||||..||.:.:
Worm   461 SELDMSMYRIQPVKEMTIVGNPSEVALLRYAS-AMLDAKELRESFQVVFEIPFNSVRKYHLILAT 524

  Fly   511 -----HETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERV 570
                 ::.:..:|..:::::|||||.:::.|||:.|||:.|.||.:..|.||.||...|..|.||
Worm   525 NKNTWNQVDKNDDVEFVVMIKGAPEVLIKNCSTMNINGESKELDLKRMEDFNEAYEAFGDEGCRV 589

  Fly   571 LGFCD----------FMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCR 625
            :||..          |.|         |.||    .|:::..|:|:.:::||||...|.|:..|:
Worm   590 IGFAQKKFRARASTVFSL---------KSNT----VPMEDWDFLGMSAIMDPPRDDTPKAIKACK 641

  Fly   626 SAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRD 690
            :|||||.||||||..||.|||:.:|:|.....:..|..|::   :...|.::  .||:.|:||..
Worm   642 AAGIKVYMVTGDHKSTATAIARQIGMIDTEEVSRVDHNQQI---IRRSNSQD--WAVITGSELPA 701

  Fly   691 VSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIA 755
            ::..|.||:|: |..||||||:|:.||:||...|:.|..|.||||||||:|||||||:|||||:|
Worm   702 LTQKQWDELLQ-HRYIVFARTTPEHKLMIVTESQKRGECVTVTGDGVNDAPALKKADVGVAMGLA 765

  Fly   756 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPL 820
            ||||:|||||:|||||||:|||.|:|||||:||||:|:||||:....||:.|.:.......||.|
Worm   766 GSDVAKQAADIILLDDNFSSIVAGIEEGRLLFDNLRKTIAYTMAHMWPELVPVILNFFFGFPLGL 830

  Fly   821 GTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFF 885
            ..|.||.|||.:|:.||:|||||..|||||.:|||.. :..||...||:..|..:.:..:.....
Worm   831 TPVQILSIDLISDIPPAVSLAYEGPEADIMLQPPRKK-DTHLVTKGLITYTYLFMSIFISIGCVC 894

  Fly   886 VYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWA 950
            .|.:....||..|.:|......:......:.|.:.|.......:..:......||.||:|:.|..
Worm   895 AYLLSYYINGIGPWELAFTASTYFKHGAANFTTAKGVILNEEQQMYMANQAAAAFHISLVLGQAF 959

  Fly   951 DLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALA 1015
            .|.:|.|||.|||..|:.|....|.::.:.:|....::.||::......|.....|...|...:.
Worm   960 HLWMCLTRRVSIFAHGLGNIVAIFAVIIDLLLICIFTFVPGVKYIFGSQPPPWQCWLVPIVVGVW 1024

  Fly  1016 IFIYDETRRFYLRRNP 1031
            |:|::|.|:..:|:.|
Worm  1025 IWIFNELRKLGIRKYP 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	380/1053 (36%)
		Cation_ATPase_N	58..132	CDD:214842	29/87 (33%)
		E1-E2_ATPase	152..383	CDD:278548	86/237 (36%)
		Cation_ATPase	445..539	CDD:289987	29/118 (25%)
		COG4087	<695..770	CDD:226572	51/74 (69%)
		Cation_ATPase_C	817..1025	CDD:279079	64/207 (31%)
catp-2	NP_504328.1	HAD_like	66..1040	CDD:389748	370/1006 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830