DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and eat-6

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_506269.1	Gene:	eat-6 / 179796	WormBaseID:	WBGene00001137	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	999	Identity:	751/999 - (75%)
Similarity:	865/999 - (86%)	Gaps:	5/999 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEW 107
            |.:||:.|.|||||:.:|.|.:..|||..|..|:.|.||:..||:|.|.::|||||:||:.||||
Worm     3 KKDKKQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEW 67

  Fly   108 VKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKS 172
            :|||||||||||||||:|||||::|||:...|.|.|:.|||||||||..||::||:|.|||||||
Worm    68 IKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQESKS 132

  Fly   173 SKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLT 237
            ||||:|||||||.||.|.|:|:|..::.|:||:||:||||.|||:|||:|::.|..|||||||||
Worm   133 SKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLT 197

  Fly   238 GESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPI 302
            ||||||||..:.|:||||||:|:||||||||||||||:||..||:|||||||.||||||||.|||
Worm   198 GESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPI 262

  Fly   303 AKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAK 367
            |:||.||||||||||||||::||:||||||||||.||:||||||||||||||:||||||||||||
Worm   263 AREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAK 327

  Fly   368 RMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRT 432
            |||||||||||||||||||||||||||||||||||||||||||:|..|.|.||||.|:. |..||
Worm   328 RMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTS-QEKRT 391

  Fly   433 SPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAE 497
            ...|:||.|||:||||||||.||...|||:::.:|||||.||||..||..|:|:.:|::||||||
Worm   392 GASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAE 456

  Fly   498 VPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYME 562
            :|||||||||||||:    |...|||||||||||||:.|||||:||||..|.::::|.||.||:|
Worm   457 IPFNSTNKYQVSIHD----NGDHYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLE 517

  Fly   563 LGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSA 627
            |||:||||||||||:||:||:|.||||:.:::|||:.||||||||||||||||||||||||||||
Worm   518 LGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSA 582

  Fly   628 GIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVS 692
            ||||:|||||||||||||||||||||:|.|||||||.|..|||.|||||||||||:||::||::|
Worm   583 GIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMS 647

  Fly   693 SDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 757
            .|||.||::||:|||||||||||||:||||.|:.|.|||||||||||||||||||||||||||||
Worm   648 EDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGS 712

  Fly   758 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGT 822
            ||||||||||||||||||||.|||||||||||||||||||||||||||||||.:||..|||||||
Worm   713 DVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGT 777

  Fly   823 VTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVY 887
            |||||||||||||||||||||.||:|||||.||||..|||||.||||:||||||||||:||||.|
Worm   778 VTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQASAGFFTY 842

  Fly   888 FVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADL 952
            |.|||:|||:|..|:.:|..|||:|.|::.|||||||||.:||.|||||.||:|:||||||||||
Worm   843 FWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADL 907

  Fly   953 IICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIF 1017
            ||.||||||:.||||.||.|||||||||.||.|:.||||::.|||||.|:..|||.|:||::.||
Worm   908 IISKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIF 972

  Fly  1018 IYDETRRFYLRRNPGGWLEQETYY 1041
            :|||.|||.:||.||||:|:||||
Worm   973 VYDEIRRFLIRRYPGGWVERETYY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	748/995 (75%)
		Cation_ATPase_N	58..132	CDD:214842	45/73 (62%)
		E1-E2_ATPase	152..383	CDD:278548	181/230 (79%)
		Cation_ATPase	445..539	CDD:289987	62/93 (67%)
		COG4087	<695..770	CDD:226572	65/74 (88%)
		Cation_ATPase_C	817..1025	CDD:279079	154/207 (74%)
eat-6	NP_506269.1	ATPase-IIC_X-K	6..996	CDD:273445	748/994 (75%)
		Cation_ATPase_N	18..92	CDD:214842	45/73 (62%)
		E1-E2_ATPase	112..343	CDD:278548	181/230 (79%)
		Cation_ATPase	404..494	CDD:289987	62/93 (67%)
		COG4087	<644..725	CDD:226572	68/80 (85%)
		Cation_ATPase_C	772..981	CDD:279079	155/208 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I597
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113729
Inparanoid	1	1.050	1483	1.000	Inparanoid score	I42
Isobase	1	0.950	-	0	Normalized mean entropy	S851
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		oto20518
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	LDO	PTHR43294
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3604
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860