DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and catp-8

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_502165.2	Gene:	catp-8 / 178070	WormBaseID:	WBGene00007514	Length:	1178	Species:	Caenorhabditis elegans

Alignment Length:	872	Identity:	182/872 - (20%)
Similarity:	326/872 - (37%)	Gaps:	223/872 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RADSYRVAT---VIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKI--SPEELY 70
            :.:..|:|:   ||.|.::.            .|..|.......|.:.:|..:|.::  :.:|..
Worm    83 KQEDVRIASHVCVIPTQNNG------------WPELVKLMRTTRDKQTKLWFEFQRVHYTWDEES 135

  Fly    71 QRFQT---------------HPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKN---LFGG 117
            :.|||               |......|.|..:.|..|....:..|:....:::....   :|..
Worm   136 REFQTKTLDTAKPMVFFQKSHGFEVEEHVKDAKYLLGDNKTEMIVPQFLEMFIERATAPFFVFQV 200

  Fly   118 FAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNM 182
            |.:.||....:.:  ||:          ..|::.:...|.::          .:..|.|...:||
Worm   201 FCVGLWCLEDMWY--YSL----------FTLFMLMTFEATLV----------KQQMKNMSEIRNM 243

  Fly   183 --VPQFATVIREGEKLTLRAEDLVLGDVVEVKFG---DRIPADIRIIEARNFKVDNSSLTGESEP 242
              ......|:|..:...::.|:||.||:|.:..|   :.:|.|:.::..... ||.|.|||||.|
Worm   244 GNKTYMINVLRGKKWQKIKIEELVAGDIVSIGRGAEEECVPCDLLLLRGPCI-VDESMLTGESVP 307

  Fly   243 QSRGAEFTHENPLE--TKNLAFFSTNAVEGTAKGVVISCG----DHTVMGRIAG----------- 290
            |.:       .|:|  .|:..|    .:|..::..||..|    .||..|:.|.
Worm   308 QMK-------EPIEDVEKDKIF----DIETDSRLHVIFGGTKIVQHTAPGKAAEGMVKSPDGNCI 361

  Fly   291 ---LASGLDTGETPIAKEIHHFIHLIT--GVAVFLGVTFFVIAFI--LGYHW------------- 335
               :.:|.:|.:..:.:.|...:...|  .:..|..:.|.:|..|  ..|.|
Worm   362 CYVIRTGFNTSQGKLLRTIMFGVKKATANNLETFCFILFLLIFAIAAAAYLWIKGSVDETRSKYK 426

  Fly   336 --LDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLE--AVETLGSTSTICSDKT 396
              |:..:.|..:|...:|      :.:.|.:.:..||.:...:...|  .:...|.....|.|||
Worm   427 LFLECTLILTSVIPPELP------IELSLAVNSSLMALQKLGIFCTEPFRIPFAGKVDICCFDKT 485

  Fly   397 GTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPIL 461
            ||||.:.:.|..:..:||         :.|:..:......::|..:|:..:...|
Worm   486 GTLTTDNLVVEGVALNNQ---------KEGMIRNAEDLPHESLQVLASCHSLVRF---------- 531

  Fly   462 KKEVSGDASEAALLK-C-MELALGD-VMNIRKRNKKIAEVP------FNSTNKYQ--VSIHETED 515
            ::::.||..|.|.|. | ..|..|| ||..:...|.|:.:.      |:|..|..  |:.:::..
Worm   532 EEDLVGDPLEKACLSWCGWNLTKGDAVMPPKTAAKGISGIKIFHRYHFSSAMKRMTVVAGYQSPG 596

  Fly   516 TNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPS 580
            |:|..:::.:|||||.:             :.:..::...::..|..|...|.|||......|..
Worm   597 TSDTTFIVAVKGAPEVL-------------RNMYADLPSDYDETYTRLTRQGSRVLAMGIRKLGE 648

  Fly   581 -------DKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDH 638
                   ||....|:          ::|.|.|.:.:..|.::.....:.:...:...|.|:|||:
Worm   649 TRVGELRDKKRENFE----------NDLAFAGFVVISCPLKSDTKTMIREIMDSSHVVAMITGDN 703

  Fly   639 PITAKAIAKSVGIISEGNETV-------------EDIAQRLNIPV--SEVNPREAKA-------- 680
            |:||..::|.:....:...|:             :.:...:.:|:  ...|..|.||
Worm   704 PLTACHVSKVLKFTKKSLPTLVLDEPADGVDWMWKSVDGTIELPLKPETKNKMERKAFFNSHEFC 768

  Fly   681 -------AVVHGAE--LRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDG 736
                   .:||...  ||:         |..|.: ||||.:|:||..|:...:.:|.:..:.|||
Worm   769 LTGSAFHHLVHNEHTFLRE---------LILHVK-VFARMAPKQKERIINELKSLGKVTLMCGDG 823

  Fly   737 VNDSPALKKADIGVAMGIAGSDVSKQA 763
            .||..|||.|::|||:.....|..|.|
Worm   824 TNDVGALKHANVGVALLTNPYDAEKAA 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	175/835 (21%)
		Cation_ATPase_N	58..132	CDD:214842	15/93 (16%)
		E1-E2_ATPase	152..383	CDD:278548	56/276 (20%)
		Cation_ATPase	445..539	CDD:289987	25/104 (24%)
		COG4087	<695..770	CDD:226572	26/69 (38%)
		Cation_ATPase_C	817..1025	CDD:279079
catp-8	NP_502165.2	P-ATPase-V	37..1153	CDD:273738	182/872 (21%)
		E1-E2_ATPase	251..>380	CDD:278548	35/140 (25%)
		Cation_ATPase	532..613	CDD:289987	24/80 (30%)
		COG4087	<793..>842	CDD:226572	21/49 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910