DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and catp-6

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001255430.2	Gene:	catp-6 / 177822	WormBaseID:	WBGene00012341	Length:	1267	Species:	Caenorhabditis elegans

Alignment Length:	1201	Identity:	254/1201 - (21%)
Similarity:	432/1201 - (35%)	Gaps:	371/1201 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRTADGQYKSRRKMPAK---VNKKEN---LDDLKQELDIDFHKISPE--------ELYQRFQ--- 74
            |.|...:....||:|..   |.:|..   :|||..:..:|  :||..        |:..|..
Worm    93 NATIPTENGEMRKVPELRWFVYRKLEYVWIDDLNSDESVD--EISDNDNCWKTSFEIANRIPCRS 155

  Fly    75 ----THPENGLSHAKAKENLERDGPNALTPPKQ-----------TPEWVKFCKNLFGGFAMLLWI 124
                :....||:.::....||..|.|.:....:           ||.:|      |..|::.:|.
Worm   156 LLAVSESNFGLTLSEISRRLEFYGRNEIVVQLRPILYLLVMEVITPFYV------FQIFSVTVWY 214

  Fly   125 GAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSY-YQESKSSKIMESFKNMVPQFAT 188
            ..     .|:..||           |.::||...||..::.. .||.:...::.|.:::     .
Worm   215 ND-----EYAYYAS-----------LIVILSLGSIVMDVYQIRTQEIRLRSMVHSTESV-----E 258

  Fly   189 VIREGEKLTLRAEDLVLGDVVEV-KFGDRIPADIRIIEARNFKVDNSSLTGESEP--------QS 244
            |||||.::|:.::.||.||::.: ..|..:..| .::......|:.|.|||||.|        ::
Worm   259 VIREGTEMTIGSDQLVPGDILLIPPHGCLMQCD-SVLMNGTVIVNESVLTGESVPITKVALTDET 322

  Fly   245 RGAEFTHENPLETKNLAFFSTNAVE------GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIA 303
            ..:.|..|.  .:||:.|..|..::      ...|.:|:.....|:.|::..........:....
Worm   323 NDSVFNIEK--NSKNVLFCGTQVLQTRFYRGKKVKAIVLRTAYSTLKGQLVRSIMYPKPVDFRFT 385

  Fly   304 KEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIF-LIGIIVANVPEGLLATVTVCLTLTAK 367
            |::..||..:..:: ..|..:.:|..|:..:.|..:|. .:.||...||..|.|.::|.:.....
Worm   386 KDLFKFILFLACIS-GCGFIYTIIVMIMRGNTLRRIIVRSLDIITITVPPALPAAMSVGIINAQL 449

  Fly   368 RMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRT 432
            |:..|.....:...:.|.|:.:.:|.|||||||::.:.. |:  ...::.|...|.|. |:.:::
Worm   450 RLKKKEIFCISPSTINTCGAINVVCFDKTGTLTEDGLDF-HV--VRPVMSAVNQEIQK-VKLEKS 510

  Fly   433 SPGFKALSRIATLCNRAEFKG------GQDGVPI---LKKEVS-------------GDASEAALL 475
                          ||.||.|      .::|:|.   |.|.::             ||..:..|.
Worm   511 --------------NRTEFMGEMTELTSRNGLPFDGDLVKAIATCHSLTRINGVLHGDPLDLILF 561

  Fly   476 K----CMELAL-GDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILER 535
            :    .||..: ||:....:|...:           |.||.:..|.....|.::.:......|:|
Worm   562 QKTGWTMEEGIEGDIEEETQRFDNV-----------QPSIIKPTDDKSAEYSVIRQFTFSSSLQR 615

  Fly   536 CSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFC-------DFMLPSDKY-PNGFKF--- 589
            .|.|..:.:|...|        |..:...|..|.:|..|       |::|..:.| .:||:.
Worm   616 MSVIVFDPREDRPD--------NMMLYSKGSPEMILSLCDPNTVPEDYLLQVNSYAQHGFRLIAV 672

  Fly   590 --NTDDINF---------PID-NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITA 642
              ...|:||         .:: :|..:||:.|.:..:......:.:...|.|:.:|||||:.:|.
Worm   673 ARRPLDLNFNKASKVKRDAVECDLEMLGLIVMENRVKPVTLGVINQLNRANIRTVMVTGDNLLTG 737

  Fly   643 KAIAKSVGII------------------------------SEGNETVEDIA-------------- 663
            .::|:..|||                              |..:|.:||.|
Worm   738 LSVARECGIIRPSKRAFLVEHVPGELDEYGRTKIFVKQSVSSSDEVIEDDASVSISMCSSTWKGS 802

  Fly   664 ------QRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEIL--RYHTEI-------------- 706
                  ...|..|...||               |::|.|..::  .||..|
Worm   803 SEGDGFSPTNTEVETPNP---------------VTADSLGHLIASSYHLAISGPTFAVIVHEYPE 852

  Fly   707 ----------VFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSK 761
                      ||||.:|.||..:||..|::...||:.|||.||..|||.|..|:::..|.:.:
Worm   853 LVDQLCSVCDVFARMAPDQKQSLVEQLQQIDYTVAMCGDGANDCAALKAAHAGISLSDAEASI-- 915

  Fly   762 QAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIPEISPF-LAFILCD---IPL 818
             ||.......:...:.|.:.|||..    |...|....|:||..:..:..: ::.||.|   :.:
Worm   916 -AAPFTSKVPDIRCVPTVISEGRAALVTSFGIFKYMAGYSLTQFVTVMHLYWISNILTDGQFMYI 979

  Fly   819 PLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMA-----YGQ---I 875
            .:..:|:..:..|.  .||.   |..|...    ||          :||:|:|     .||   |
Worm   980 DMFLITMFALLFGN--TPAF---YRLAHTP----PP----------TRLLSIASMTSVVGQLIII 1025

  Fly   876 GMIQAAAGFFVYFVIMAENGFLPKK-----------------LFGIR------------------ 905
            |::|    |.|:|....:..|.|.:                 ||.:.
Worm  1026 GVVQ----FIVFFSTSQQPWFTPYQPPVDDEVEDKRSMQGTALFCVSMFQYIILALVYSKGPPFR 1086

  Fly   906 -KMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRN--------- 960
             .:|.:|.:..||                   ..|..:.:.:|.|...::.||..|
Worm  1087 GNLWSNKPMCALT-------------------IFATLLCLFIVIWPTELVLKTLGNVELPSLTFR 1132

  Fly   961 -SIFQQGMRNWALNFGLVFETVLAAF--LSY 988
             .|...|..|.|:::|  |||:...|  |.|
Worm  1133 IFIVIVGAVNAAVSYG--FETLFVDFFLLGY 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	248/1180 (21%)
		Cation_ATPase_N	58..132	CDD:214842	17/99 (17%)
		E1-E2_ATPase	152..383	CDD:278548	54/247 (22%)
		Cation_ATPase	445..539	CDD:289987	25/120 (21%)
		COG4087	<695..770	CDD:226572	29/100 (29%)
		Cation_ATPase_C	817..1025	CDD:279079	45/228 (20%)
catp-6	NP_001255430.2	P-ATPase-V	18..1137	CDD:273738	244/1173 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910