Protein Alignment Atpalpha and mca-3

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001380077.1
• Gene: mca-3 / 177089
• WormBaseID: WBGene00003153
• Length: 1234
• Species: Caenorhabditis elegans
• Alignment Length: 1101
• Identity: 300/1101 - (27%)
• Similarity: 483/1101 - (43%)
• Gaps: 280/1101 - (25%)

  Fly    52 DLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERD----GPNALT--PPKQTPEWVKF 110
            :.|::::.|:.  ....|.:|.:|.|.|||.:  .:|.|||.    |.|.:.  |||
 Worm    21 EAKEKIETDYG--GTTGLCERLKTDPNNGLPN--NEEELERRRNVFGANEIPPHPPK-------- 73

  Fly   111 CKNLFGGFAMLLW------------IGAILCFVAYSIQASTSEEPA--DDNLY-------LGIVL 154
            |      |..|:|            :.||:. :|.|......|:.|  ||:.:       :.|::
 Worm    74 C------FLQLVWEALQDVTLVILLVSAIVS-LALSFYRPPGEDTAGSDDSEHDAGWIEGVAILI 131

  Fly   155 S--AVVIVTGIFSYYQESKSSKIMESFKNMVPQFAT-----VIREGEKLTLRAEDLVLGDVVEVK 212
            |  .||:||.:..|.:|       ..|:.:..:..|     |:|.|:.:.:...:||:||:.::|
 Worm   132 SVIVVVLVTALNDYTKE-------RQFRGLQAKIETEHRFFVLRGGQSVQVVVNELVVGDIAQIK 189

  Fly   213 FGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVI 277
            :||.||:|..||::.:.|:|.|||||||:...:..|  |:      .:....|:.:||:.|.:|.
 Worm   190 YGDLIPSDGIIIQSNDLKMDESSLTGESDQIRKSPE--HD------PIILSGTHVMEGSGKMLVT 246

  Fly   278 SCGDHTVMGRIAGL----------------------ASGLDTGE--------------------- 299
            :.|.::..|.|..|                      |||.:.|.
 Worm   247 AVGVNSQTGIIMTLLGAAKTVAEEERKTAKREGGDGASGAEEGTAQALLDSKGDEAMANGKAVAA 311

  Fly   300 ----------------TPIAKEIHHFIHLITGVAVFLGVTFFVI--------AFILG--YHWLDA 338
                            |.:|.:|.:....:.|..|.:.:..|.|        :|.|.  .|:::.
 Worm   312 AESDGKKERSVLQAKLTRLAIQIGYAGSFVAGCTVLILIIRFCISRYAIDGKSFSLADFQHFINF 376

  Fly   339 VIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNR 403
            :|..:.::|..|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.||
 Worm   377 LIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMLDNNLVRHLDACETMGNATAICSDKTGTLTTNR 441

  Fly   404 MTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVS-- 466
            |||... |.|.:...||.:.:|   .|:.:      :::...|...........:|  .|::.
 Worm   442 MTVVQS-FVNDVHYKDTPKIES---LDQNT------AKLMMDCISINSSYSSQVIP--PKQLGEQ 494

  Fly   467 ----GDASEAALLKCMELALG-DVMNIRKRN--KKIAEV-PFNSTNKYQVSIHETEDTNDPRYLL 523
                |:.:|..:|..: |||| ....||.|:  :.|.:| .|||..|   |:....:..|..|.:
 Worm   495 ATQLGNKTECGMLGFV-LALGKSYQEIRDRHPEETIPKVYTFNSVRK---SMSTVINLPDGGYRV 555

  Fly   524 VMKGAPERILERCSTIFINGKEKVLDE-EMKEAFNNAY-----MELGGLGERVLGFCDFMLPSDK 582
            ..|||.|.:.:||.  :..||...|.: ..|:|.|...     |...||....:.:.|: :||.|
 Worm   556 FSKGASEIVTKRCK--YFLGKNGTLTKFSSKDAENLVRDVIEPMASDGLRTICVAYKDY-VPSSK 617

  Fly   583 --YPNGFKFNT----DDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPIT 641
              ..|...:::    ::....:.::..:.::.:.||.|..||.|:.:|:.|||.|.|||||:..|
 Worm   618 KTADNQIAYSSEPDWENEEMIVGDMTAIAVLGIQDPVRPEVPAAITRCQEAGITVRMVTGDNINT 682

  Fly   642 AKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---LRYH 703
            |::||.:.||:..|.:.:....:..|..:.:.|              .:||.::||.|   ||
 Worm   683 ARSIATACGILKPGEDFIALEGKEFNARIRDEN--------------GEVSQEKLDLIWPKLR-- 731

  Fly   704 TEIVFARTSPQQKLIIVEGC--QRM---GAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQA 763
               |.||..|..|.::|:|.  .|:   ..:|||||||.||.|||||||:|.||||||:||:|:|
 Worm   732 ---VLARAQPSDKYVLVKGIIDSRVTDSREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEA 793

  Fly   764 ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFI-LCDI-PLPLGTVTIL 826
            :|:||.||||.|||..|..||.::|::.|.:.:.||.|:  ::..:||: .|.| ..||..|.:|
 Worm   794 SDIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNV--VAVVVAFVGACAIQDTPLKAVQML 856

  Fly   827 CIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLISMA------------YGQIG 876
            .::|..|.:.:::||.|....:::||.|   ..|...:.:...::..|            ||::
 Worm   857 WVNLIMDTLASLALATEMPTEELLKRKPYGRTSPLISRTMCKNILGHAVYQLVILFTLIFYGEV- 920

  Fly   877 MIQAAAG---------------FFVYFVIMA-ENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWT 925
            .....:|               .|..||:|. .|....:|:.|.|.::.....|
 Worm   921 CFNIPSGRWAPLHSPPSKHFTIVFNTFVMMTLFNEINARKIHGERNIFKGLFSN----------- 974

  Fly   926 YRDRKTLEYTCHTAFFISIVVV-----QWADLIICKTRRNSIFQQGMRN-----WALNFGL 976
                 .:.|....|..||.||:     :|             |.....|     |.|.||:
 Worm   975 -----PIYYVIWIATMISQVVIIQFGGRW-------------FSTSALNTTEWLWCLAFGV 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	300/1101 (27%)
		Cation_ATPase_N	58..132	CDD:214842	23/91 (25%)
		E1-E2_ATPase	152..383	CDD:278548	76/306 (25%)
		Cation_ATPase	445..539	CDD:289987	28/103 (27%)
		COG4087	<695..770	CDD:226572	43/82 (52%)
		Cation_ATPase_C	817..1025	CDD:279079	39/201 (19%)
mca-3	NP_001380077.1	P-type_ATPase_Ca_PMCA-like	55..896	CDD:319776	264/910 (29%)
		Cation_ATPase_C	849..1026	CDD:376368	39/199 (20%)
		ATP_Ca_trans_C	1066..1108	CDD:403580

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920