DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and catp-4

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_497034.2	Gene:	catp-4 / 175120	WormBaseID:	WBGene00007248	Length:	1015	Species:	Caenorhabditis elegans

Alignment Length:	1035	Identity:	541/1035 - (52%)
Similarity:	713/1035 - (68%)	Gaps:	47/1035 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPN 96
            |.:|.:     |.||  :|:|||:::.||.|:|..:.|::|:.|..:||:|.|:|...|.|||||
Worm     3 GCFKKK-----KTNK--SLEDLKKDVVIDDHEIPLDALFKRYTTSEKNGISEAEATNRLNRDGPN 60

  Fly    97 ALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTS--EEPADDNLYLGIVLSAVVI 159
            ||||||||.:|:|...::||||..|||..|....|.|.:..|.|  ||...||:|:.|:|:.||.
Worm    61 ALTPPKQTSKWIKLAGSIFGGFNFLLWCAASASAVGYGMDLSMSDDEEVPKDNMYMAIILATVVT 125

  Fly   160 VTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRII 224
            |||:|.:||..||..:|:||.||:|....|:|:|....:..:|||:||:|..:.|||:|||:|:.
Worm   126 VTGLFDFYQNRKSGNLMDSFANMIPPKTLVVRDGATREIEVKDLVVGDLVRFRGGDRVPADLRVT 190

  Fly   225 EARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIA 289
            .||..||||||||||||||:|....|.:|.||||||..|||:.:||:.:|::|..||.|.:||||
Worm   191 LARGLKVDNSSLTGESEPQTRNMNCTSKNALETKNLCMFSTSVLEGSGEGIIIGTGDRTFVGRIA 255

  Fly   290 GLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGL 354
            .|.:.:|.|.||:||||:|||.:|:.||..:|:.||::|.:..|..|.|::|.:||:|||||||:
Worm   256 ALTTQVDPGPTPLAKEINHFIKIISIVAFTVGIAFFILALVYEYPPLKAIVFFMGIVVANVPEGI 320

  Fly   355 LATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEAD 419
            :.||||.|||||.:|..|.||||.|:||||||||||||||||||||||||||.|:|||.:|.:.:
Worm   321 VPTVTVSLTLTAVKMRKKFCLVKKLQAVETLGSTSTICSDKTGTLTQNRMTVTHLWFDGKIKDTE 385

  Fly   420 ---TTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELA 481
               ..:...|.:.......::.|.|.||||:|:.|:..:..||:.|:.|:|||||.|:::..|:.
Worm   386 ILPPNDHFKGEKKYEKEDSYQKLLRCATLCSRSHFRVPEFDVPLAKRVVNGDASEVAIMRYCEMI 450

  Fly   482 LGD--VMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGK 544
            .||  |...||...||.|:|||||||||:|||......:   :||||||||:||:.|||.:.||:
Worm   451 RGDGQVDEFRKIMPKIGEIPFNSTNKYQLSIHPMSKKQN---ILVMKGAPEKILKLCSTYYQNGE 512

  Fly   545 EKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSM 609
            .|.:.::.::.|..||..||..|||||||||..:.:.|:|.|||||.::.||||.||||:||:||
Worm   513 TKNVSKKFEKEFQQAYETLGSYGERVLGFCDLEMSTTKFPPGFKFNMEEPNFPIKNLRFLGLISM 577

  Fly   610 IDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVN 674
            |||||..||:||..|::|||:|:||||||||||:|||..|.||.|            |:.|:|:.
Worm   578 IDPPRPGVPEAVRVCQNAGIRVVMVTGDHPITARAIANQVHIIEE------------NVQVTEIV 630

  Fly   675 PREAK------------------AAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVE 721
            ..:.|                  |.|:||.:|..:|...|..::..:.:||||||||.|||.|||
Worm   631 NADPKCDPASDEIYGKGRLKPTGAVVIHGEQLTTMSPKTLKAVVTNYHQIVFARTSPAQKLQIVE 695

  Fly   722 GCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLI 786
            ..|.:|.||.||||||||:|||:|||||:||||.|:||||||||||||:||||||||||||||||
Worm   696 AFQSVGNIVGVTGDGVNDAPALRKADIGIAMGITGTDVSKQAADMILLNDNFASIVTGVEEGRLI 760

  Fly   787 FDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMK 851
            |||||||||||||||||||:||::::|..:|||:..:.||.||||||:.||||.|||..|:|||:
Worm   761 FDNLKKSIAYTLTSNIPEITPFMSYVLFGLPLPMSIIAILMIDLGTDLWPAISFAYEVPESDIMQ 825

  Fly   852 RPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDL 916
            |.||:|..|||||.||:..:|.|||.|||.|||..|||:|..||:.|:.|..|.:.||:|.::||
Worm   826 RAPRNPLYDKLVNKRLVMFSYMQIGAIQACAGFTTYFVLMMSNGWFPQDLLNISEQWDNKYIDDL 890

  Fly   917 TDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETV 981
            .|||||:|:|..||.||..|:..||.:|||.||:||...|||:||:..|||.|..||..::|...
Worm   891 EDSYGQQWSYESRKALESCCYGTFFFTIVVTQWSDLFASKTRKNSLVMQGMENHVLNTSVIFTCF 955

  Fly   982 LAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||.|:...|.:.:.|.:...:|...|.|:|||..|.:|||.||:::|..|||::.:||||
Worm   956 LAIFVLNTPFVNEVLGVQGFRLEIGFLALPFAFFIGLYDEVRRYFIRTYPGGYIYKETYY 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	536/1020 (53%)
		Cation_ATPase_N	58..132	CDD:214842	36/73 (49%)
		E1-E2_ATPase	152..383	CDD:278548	122/230 (53%)
		Cation_ATPase	445..539	CDD:289987	47/95 (49%)
		COG4087	<695..770	CDD:226572	51/74 (69%)
		Cation_ATPase_C	817..1025	CDD:279079	106/207 (51%)
catp-4	NP_497034.2	ATPase-IIC_X-K	9..1015	CDD:273445	537/1022 (53%)
		Cation_ATPase_N	24..95	CDD:214842	35/70 (50%)
		E1-E2_ATPase	118..349	CDD:278548	122/230 (53%)
		Cation_ATPase	414..507	CDD:289987	47/95 (49%)
		HAD	<582..718	CDD:289480	66/147 (45%)
		Cation_ATPase_C	791..1000	CDD:279079	107/208 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I659
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830