DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp12a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_598201.2	Gene:	Atp12a / 171028	RGDID:	620569	Length:	1036	Species:	Rattus norvegicus

Alignment Length:	1012	Identity:	642/1012 - (63%)
Similarity:	798/1012 - (78%)	Gaps:	2/1012 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGP 95
            |.::|..:....:.||....::||:|||:|.|::|..||.|::.|:...|||..:|.|.|.||||
  Rat    26 DKKFKGAKNKDLEPNKSHEKEELKKELDLDDHRLSNTELEQKYGTNIIQGLSSVRATELLARDGP 90

  Fly    96 NALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIV 160
            |.|||||||||.:||.|.:.|||::||||||.||::|:.|| ..:...:.||:|||.:|..|||:
  Rat    91 NTLTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAFVIQ-YVNNSASLDNVYLGAILVLVVIL 154

  Fly   161 TGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIE 225
            ||||:||||:||:.||.||..|:||.|.|||:.||..:.||.||:|||||:|.||:||||||::.
  Rat   155 TGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEIKGGDQIPADIRLVF 219

  Fly   226 ARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAG 290
            ::..||||||||||||||:|..||||||||||||:.|:||..:||||.|:||:.||.|::||||.
  Rat   220 SQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIAS 284

  Fly   291 LASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLL 355
            ||||:.:.:||||.||.||:|::.||||.:|:.||:.|..:.|:.|||:||||.|||||||||||
  Rat   285 LASGVGSEKTPIAIEIEHFVHIVAGVAVSIGIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLL 349

  Fly   356 ATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADT 420
            |||||.|:|||||||.||||||||||||||||||.||||||||||||||||||:||||||..|||
  Rat   350 ATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADT 414

  Fly   421 TEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDV 485
            :|:|:...:|::|..:.:||:|.||||||||:.||:.|||:|:.|.|||||.||||..|:.||||
  Rat   415 SENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRTVVGDASETALLKFSEVILGDV 479

  Fly   486 MNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDE 550
            |.|||||.|:||:|||||||:|:|||||||.||.|:|:|||||||||||:||||.|||:|:.||:
  Rat   480 MGIRKRNHKVAEIPFNSTNKFQLSIHETEDPNDKRFLVVMKGAPERILEKCSTIMINGQEQPLDK 544

  Fly   551 EMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRA 615
            ...::|:.||||||||||||||||...||::::|..:.|:.|.:|||..|..||||:|||||||:
  Rat   545 SSADSFHTAYMELGGLGERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGLLSMIDPPRS 609

  Fly   616 AVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKA 680
            .|||||:|||||||||||||||||||||||||||||||..||||||||:|.||.|.:||.|||||
  Rat   610 TVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKA 674

  Fly   681 AVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKK 745
            |||.|.||:|::.:||||:|..:.|||||||||||||||||||||..||||||||||||||||||
  Rat   675 AVVTGMELKDMTPEQLDELLTNYQEIVFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKK 739

  Fly   746 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLA 810
            ||||:||||||||.:|.||||:|||||||||||||||||||||||||:||||||.||.|:.|||.
  Rat   740 ADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLI 804

  Fly   811 FILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQI 875
            :|:..:|||:||:|||.||||||::|:|:||||.||:|||.|.||....|:|||::|...:|..|
  Rat   805 YIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNTQLAIYSYLHI 869

  Fly   876 GMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAF 940
            |::||..||.|||.:.|:.||.|..|..:|..|::..:|||.||||||||...||.||:|..|||
  Rat   870 GLMQALGGFLVYFTVYAQQGFWPTSLINLRVAWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAF 934

  Fly   941 FISIVVVQWADLIICKTRRNSIFQQGM-RNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLV 1004
            |::|::.|.|||||.|||||||||||: ||..:..|:..:.::|..|||..|....|....|::.
  Rat   935 FVAIMIQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGLGSVPALSFTMLRVQ 999

  Fly  1005 WWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            :||.|:|.|:.|::|||.|:.::|..||.|.::..||
  Rat  1000 YWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	638/996 (64%)
		Cation_ATPase_N	58..132	CDD:214842	42/73 (58%)
		E1-E2_ATPase	152..383	CDD:278548	152/230 (66%)
		Cation_ATPase	445..539	CDD:289987	69/93 (74%)
		COG4087	<695..770	CDD:226572	62/74 (84%)
		Cation_ATPase_C	817..1025	CDD:279079	108/208 (52%)
Atp12a	NP_598201.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		5/23 (22%)
		ATPase-IIC_X-K	40..1036	CDD:273445	638/996 (64%)
		Cation_ATPase_N	53..124	CDD:214842	40/70 (57%)
		E1-E2_ATPase	146..377	CDD:278548	152/230 (66%)
		Cation_ATPase	439..533	CDD:289987	69/93 (74%)
		HAD	<613..738	CDD:289480	101/124 (81%)
		Cation_ATPase_C	811..1021	CDD:279079	108/209 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830