DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and Atp2c1

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_038936656.1	Gene:	Atp2c1 / 170699	RGDID:	621311	Length:	983	Species:	Rattus norvegicus

Alignment Length:	1013	Identity:	291/1013 - (28%)
Similarity:	475/1013 - (46%)	Gaps:	167/1013 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLE 91
            |:.|:.|....:|:| .|..:..:..|..:   ...:::..|:....|...:|||:.::......
  Rat    30 NQKAEEQVARFQKIP-NVENETMIPVLTSK---RASELAVSEVAGLLQADLQNGLNKSEVSHRRA 90

  Fly    92 RDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSA 156
            ..|.|.....:..|.|.|:.........|||...|::..:......:.|           |.::.
  Rat    91 FHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMRQFDDAVS-----------ITVAI 144

  Fly   157 VVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADI 221
            :::||  .::.||.:|.|.:|....:||.....:|||:.....|.|||.||.|.:..|||:|||:
  Rat   145 LIVVT--VAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADL 207

  Fly   222 RIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLET-------KNLAFFSTNAVEGTAKGVVISC 279
            |:.||.:..:|.||||||:.|.|:   .|...|..|       .|:||..|....|.|||:||..
  Rat   208 RLFEAVDLSIDESSLTGETTPCSK---VTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGIVIGT 269

  Fly   280 GDHTVMGRIAGLASGLDTGETP-------IAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLD 337
            |:::..|.:..:....:..:||       :.|::..:...|.|:.:.:|       ::||...|:
  Rat   270 GENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG-------WLLGKDILE 327

  Fly   338 AVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQN 402
            .....:.:.||.:||||...|||.|.|...||..|..:||.|..|||||..:.||||||||||:|
  Rat   328 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKN 392

  Fly   403 RMTVAHMWFDNQIIEADTTEDQSGVQYDRTSP---------GF--KALSRI---ATLCNRAEFKG 453
            .|||.|: ..:..:.|:.|    ||.|::...         ||  .|:|||   ..:||
  Rat   393 EMTVTHI-LTSDGLHAEVT----GVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCN------ 446

  Fly   454 GQDGVPILKKEVSGDASEAALLK-CMELALGDVMN--IRKRNKKIAEVPFNSTNKYQV--SIHET 513
              |.| |....:.|..:|.||:. .|::.|..:..  |||     ||.||:|..|:..  .:|.|
  Rat   447 --DAV-IRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRK-----AEYPFSSEQKWMAVKCVHRT 503

  Fly   514 EDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFML 578
            :  .|...:..||||.|::::.|:|....|:...|.::.::.:.....::|..|.|||....
  Rat   504 Q--QDRPEICFMKGAYEQVIKYCTTYNSKGQTLALTQQQRDLYQQEKAQMGSAGLRVLALAS--- 563

  Fly   579 PSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAK 643
                       ..|     :..|.|:||:.:|||||..|.:||....::|:.:.|:|||...||.
  Rat   564 -----------GPD-----LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAI 612

  Fly   644 AIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVF 708
            |||..:|:.|:.:::|.                        |.|:..:....|.:|:  ....||
  Rat   613 AIASRLGLYSKTSQSVS------------------------GEEVDTMEVQHLSQIV--PKVAVF 651

  Fly   709 ARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNF 773
            .|.||:.|:.|::..|:.|::||:|||||||:.|||.||||||||..|:||.|:||||||:||:|
  Rat   652 YRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDF 716

  Fly   774 ASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAI 838
            .:|::.:|||:.|::|:|..:.:.|:::|..::......|.:.|.||..:.||.|::..|..||.
  Rat   717 QTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQ 781

  Fly   839 SLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAG-FFVYFVIMAENGFLPKKLF 902
            ||..|..:.|::::|||: :.|.::...||....  :..|....| .||::..:.:|...|
  Rat   782 SLGVEPVDKDVIRKPPRN-WKDSILTKNLILKIL--VSSIIIVCGTLFVFWRELRDNVITP---- 839

  Fly   903 GIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGM 967
                                    || .|:.:||...|       ...:.:..:::..|:|:.|:
  Rat   840 ------------------------RD-TTMTFTCFVFF-------DMFNALSSRSQTKSVFEIGL 872

  Fly   968 RNWALNFGLVFETVLAAFL-SYCPGMEKGLRMYPLKLV 1004
            .:..:....|..:::...| .|.|.::|..:...|.::
  Rat   873 CSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSIL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	285/995 (29%)
		Cation_ATPase_N	58..132	CDD:214842	14/73 (19%)
		E1-E2_ATPase	152..383	CDD:278548	79/244 (32%)
		Cation_ATPase	445..539	CDD:289987	29/98 (30%)
		COG4087	<695..770	CDD:226572	41/74 (55%)
		Cation_ATPase_C	817..1025	CDD:279079	40/190 (21%)
Atp2c1	XP_038936656.1	P-type_ATPase_SPCA	88..930	CDD:319779	279/951 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920