DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and AgaP_AGAP008085

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_317372.3	Gene:	AgaP_AGAP008085 / 1277866	VectorBaseID:	AGAP008085	Length:	1199	Species:	Anopheles gambiae

Alignment Length:	745	Identity:	174/745 - (23%)
Similarity:	297/745 - (39%)	Gaps:	188/745 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 PEWVKFCKN-------LFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTG 162
            ||:::..|.       :|..|::|||     |.              |:.:|..:....::::..
Mosquito   199 PEFLELFKERATAPFFVFQIFSVLLW-----CL--------------DEYMYYSLFTLCMLVIFE 244

  Fly   163 IFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEV-KFGDR--IPADIRII 224
            .....|:.:|...:....|. |....|.|......:.:..||.||:|.| :..|.  :|.|:.:|
Mosquito   245 CVLVQQQLRSLSEIRKMGNK-PYQINVFRNRRWRPISSAKLVPGDLVSVTRSQDENIVPCDLLLI 308

  Fly   225 EARNFKVDNSSLTGESEPQSRGA----EFTHENPLETK-----NLAFFSTNAVEGTA--KGVVIS 278
            .. :..||.|.|||||.||.:.:    ...|:..|:.:     ::.|..|..|:.:|  ||.:.|
Mosquito   309 RG-SCIVDESMLTGESVPQMKESLENNTDEHDKVLDIEADGKLHVLFRGTKVVQHSAPSKGAMRS 372

  Fly   279 CGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLIT--GVAVFLGVTFFVIAFILG--YHW---- 335
             .|:..:|.:  |.:|.:|.:..:.:.|...:..:|  .:..|..:.|.::..:..  |.|
Mosquito   373 -PDNGCIGYV--LRTGFNTSQGKLLRTILFGVKRVTENNLETFAFILFLLVFAVAAATYVWIKGT 434

  Fly   336 -----------LDAVIFLIGIIVANVPEGLLATVTVCLTLTAK---------RMASKNCLVKNLE 380
                       |:..:.|..||..::|..|...|...|...:|         ||
Mosquito   435 EDPERNRYKLFLECTLILTSIIPPDLPIELSLAVNTSLLQLSKVYVYCTEPFRM----------- 488

  Fly   381 AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIE--ADTTEDQSGVQYDRTSPGFKALSRIA 443
              ...|.....|.|||||||.          ||.::|  |...:|.|.|......   :|.:.:.
Mosquito   489 --PFAGKVQICCFDKTGTLTS----------DNLLVEGVAGLKQDTSIVPIGEIP---EATAHVL 538

  Fly   444 TLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCME--LALGDVMNIRKRNKKIA-----EVPFN 501
            ..|:         .:..|.:.:.||..|.|.|..::  |..||.. :.||.|..|     ...|:
Mosquito   539 GSCH---------SLVQLDEGLVGDPLEKATLTAIDWNLTKGDSC-VPKRGKFKALRIYHRFHFS 593

  Fly   502 STNKYQVSI---HETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMEL 563
            |:.| ::|:   :....:|:..|:..:|||||.|::...|:             .|.:...|:|.
Mosquito   594 SSLK-RMSVLAGYLMPFSNETCYIGTVKGAPEVIVKMLKTV-------------PEHYERTYLEY 644

  Fly   564 GGLGERVLGFCDFMLPSDKYPNGFK-FNT-----------DDINFPIDNLRFVGLMSMIDPPRAA 616
            ...|.|||..            |:| |.|           ||:.   .:|.|.|.:.:..|.:..
Mosquito   645 SRRGARVLAL------------GYKSFGTLDNNTVRELKRDDVE---RDLEFAGFIIISCPLKPD 694

  Fly   617 VPDAVAKCRSAGIKVIMVTGDHPITAKAIAK-------SVGIIS-----EGNET------VEDIA 663
            ...|:.:...|..||:|:|||:|:||..:||       ::.|::     .|:.|      .|.|.
Mosquito   695 SKYAIKEIIQASHKVMMITGDNPLTACHVAKELRFSRRTIVILTPPEELNGSTTGAGEWHWESIN 759

  Fly   664 QRLNIPVSEVNPREAKAA---VVHGAELRDVSSDQ---LDEILRYHTEIVFARTSPQQKLIIVEG 722
            :.|.:|:.....:|....   .:.|..|:.:..::   |.:::.|.|  ||||.:|:||..::..
Mosquito   760 RELRLPLDSRTVKELYKEYDFCITGEGLQYLGRERHAYLQQLIPYAT--VFARFAPKQKEYVLTT 822

  Fly   723 CQRMGAIVAVTGDGVNDSPALKKADIGVAM 752
            .:::|....:.|||.||..|||.|.:||::
Mosquito   823 LKKLGYYTLMCGDGTNDVGALKHAHVGVSL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	174/745 (23%)
		Cation_ATPase_N	58..132	CDD:214842	9/33 (27%)
		E1-E2_ATPase	152..383	CDD:278548	57/272 (21%)
		Cation_ATPase	445..539	CDD:289987	26/103 (25%)
		COG4087	<695..770	CDD:226572	22/61 (36%)
		Cation_ATPase_C	817..1025	CDD:279079
AgaP_AGAP008085	XP_317372.3	P-ATPase-V	64..1168	CDD:273738	174/745 (23%)
		E1-E2_ATPase	250..477	CDD:278548	54/231 (23%)
		Cation_ATPase	<552..633	CDD:289987	24/82 (29%)
		COG4087	<793..859	CDD:226572	22/62 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910