DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and ATC1_ANOGA

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_001688815.1	Gene:	ATC1_ANOGA / 1276852	VectorBaseID:	AGAP006186	Length:	1018	Species:	Anopheles gambiae

Alignment Length:	1084	Identity:	334/1084 - (30%)
Similarity:	512/1084 - (47%)	Gaps:	193/1084 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWI 124
            |.|..:.:|:...|:..||.|||..:.||..::.|||.|...:....|....:........:|.:
Mosquito     3 DGHSKTVDEVLSHFRVDPERGLSLDQVKEYQKKYGPNELPAEEGKTLWQLVLEQFDDLLVKILLL 67

  Fly   125 GAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATV 189
            .||:.||.    |...|....:......|:..::|...:...:||..:...:|:.|...|:...|
Mosquito    68 AAIISFVL----ALFEEHEGVEAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKV 128

  Fly   190 IREGEK---LTLRAEDLVLGDVVEVKFGDRIPADIRIIE--ARNFKVDNSSLTGES--------- 240
            || |:|   ..:||:::|.||||||..||:||||||:|:  :...::|.|.|||||
Mosquito   129 IR-GDKSGVQKIRAKEIVPGDVVEVSVGDKIPADIRLIKIYSTTIRIDQSILTGESVSVIKHTDA 192

  Fly   241 EPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKE 305
            .|..|...      .:.||:.|..||...|.|:||||..|.:|.:|:|....|..:..:||:.::
Mosquito   193 VPDPRAVN------QDKKNILFSGTNVAAGKARGVVIGTGLNTAIGKIRTEMSETEEIKTPLQQK 251

  Fly   306 IHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATVTV 360
            :..|...::.|...:.|..:.|..      ..|..|:...::    .:.:.||.:||||.|.:|.
Mosquito   252 LDEFGEQLSKVISLICVAVWAINIGHFNDPAHGGSWIKGAVYYFKIAVALAVAAIPEGLPAVITT 316

  Fly   361 CLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADT--TE- 422
            ||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|:.|:...:|...|:  ||
Mosquito   317 CLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFEKIEGNDSSFTEF 381

  Fly   423 DQSGVQYDR-----------TSPGFKALSRIATLC-----NRAEFKGGQDGVPILKK--EVSGDA 469
            :.||..|:.           .:..::.|..:.|:|     :..:|..       .||  |..|:|
Mosquito   382 EISGSTYEPIGEVTLNGQRIKAADYETLHELGTICIMCNDSAIDFNE-------TKKVFEKVGEA 439

  Fly   470 SEAALLKCMELALGDVMNIRKRN------------------KKIAEVPFN----STNKYQVSIHE 512
            :|.||:...|..  :..|:.|:.                  ||...:.|:    |.:.|...:..
Mosquito   440 TETALIVLAEKL--NPFNVAKQGLDRRSSAICVRQEIETKWKKEFTLEFSRDRKSMSSYCTPLKA 502

  Fly   513 TEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEA---FNNAYMELGGLGE---RVL 571
            ::..|.|:  |..|||||.:||||:...:...:..|.:.:|:.   ....|    |.|.   |.|
Mosquito   503 SKLGNGPK--LFCKGAPEGVLERCTHARVGSTKVPLTQTLKQRILDLTRTY----GTGRDTLRCL 561

  Fly   572 GFCDF---MLPSDKYPN-GFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVI 632
            .....   |.|.|...| ..||.|.::     ||.|||::.|:||||..|.|::.:||:|||:||
Mosquito   562 ALATADSPMKPDDMDLNDSTKFYTYEV-----NLTFVGVVGMLDPPRKEVQDSIVRCRAAGIRVI 621

  Fly   633 MVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVS-SDQL 696
            ::|||:..||:||.:.:|:..|..:|.                    .....|.|..|:| |:|.
Mosquito   622 VITGDNKATAEAICRRIGVFGEDEDTT--------------------GKSYSGREFDDLSVSEQR 666

  Fly   697 DEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSK 761
            :...|..   :|:|..|..|..|||..|.|..|.|:|||||||:||||||:||:||| :|:.|:|
Mosquito   667 EACSRAR---LFSRVEPAHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAK 727

  Fly   762 QAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPE-ISPFLAFILCDIPLPLGTVTI 825
            .||:|:|.||||:|||..|||||.|::|:|:.|.|.::|||.| :|.||...| .:|..|..|.:
Mosquito   728 SAAEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAAL-GLPEALIPVQL 791

  Fly   826 LCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLI--SMAY-GQIGMIQAAAGFFVY 887
            |.::|.||.:||.:|.:...:.|||.:|||.. ::.|::..|.  .||. |.:|.  |..|...:
Mosquito   792 LWVNLVTDGLPATALGFNPPDLDIMTKPPRKA-DEGLISGWLFFRYMAIGGYVGC--ATVGGAAW 853

  Fly   888 FVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSY-----GQEWTYRDRKTLEYTCHTAFFISIVV- 946
            :.:.:|.|  |:..:     |      .||...     |:|:...|.|...........:|::|
Mosquito   854 WFMFSETG--PQLSY-----W------QLTHHLSCLGGGEEFKGIDCKIFNDPHPMTMALSVLVT 905

  Fly   947 VQWADLIICKTRRNSIFQQGMRNW-------------ALNFGLVFETVLAAFLSYCP--GMEKGL 996
            ::..:.:...:...|:.|  |..|             ||:|.:::..||:......|  |.|
Mosquito   906 IEMLNAMNSLSENQSLVQ--MPPWCNIWLIASMCLSFALHFVILYVDVLSTVFQVTPLDGNE--- 965

  Fly   997 RMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETY 1040
                     |...:.|:|.:.:.||..:|..||...|    |:|
Mosquito   966 ---------WMTVMKFSLPVVLLDEILKFVARRISDG----ESY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	334/1084 (31%)
		Cation_ATPase_N	58..132	CDD:214842	20/71 (28%)
		E1-E2_ATPase	152..383	CDD:278548	81/254 (32%)
		Cation_ATPase	445..539	CDD:289987	30/122 (25%)
		COG4087	<695..770	CDD:226572	38/74 (51%)
		Cation_ATPase_C	817..1025	CDD:279079	53/231 (23%)
ATC1_ANOGA	XP_001688815.1	P-type_ATPase_SERCA	5..988	CDD:319778	328/1068 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920