DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atpalpha and AgaP_AGAP002858

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_003436267.1	Gene:	AgaP_AGAP002858 / 1273109	VectorBaseID:	AGAP002858	Length:	1040	Species:	Anopheles gambiae

Alignment Length:	1042	Identity:	976/1042 - (93%)
Similarity:	1010/1042 - (96%)	Gaps:	3/1042 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALRSDYEHGRADSYRVATVIATDDDNRTADGQYK-SRRKMPAKVNKKENLDDLKQELDIDFHKI 64
            ||...|.|.||.||||||||....|||||||||:| ||||||.|  ||.:|||||||||||:|||
Mosquito     1 MARSMDEETGRTDSYRVATVAPLKDDNRTADGQFKVSRRKMPPK--KKTDLDDLKQELDIDYHKI 63

  Fly    65 SPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILC 129
            :|||||||.||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mosquito    64 TPEELYQRLQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFALLLWIGAILC 128

  Fly   130 FVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGE 194
            |:||||||||.||||||||||||||:||||||||||||||||||||||||||||||||||:||||
Mosquito   129 FIAYSIQASTVEEPADDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVLREGE 193

  Fly   195 KLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKN 259
            ||||||||||:|||||||||||||||||||||||||||||||||||||||||.:|||||||||||
Mosquito   194 KLTLRAEDLVIGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGPDFTHENPLETKN 258

  Fly   260 LAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTF 324
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mosquito   259 LAFFSTNAVEGTAKGVVISCGDFTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTF 323

  Fly   325 FVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTS 389
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   324 FVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTS 388

  Fly   390 TICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGG 454
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mosquito   389 TICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIASLCNRAEFKGG 453

  Fly   455 QDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDP 519
            |||||||||||||||||||||||||||||||::|||||||:.|:|||||||||||||||||.:||
Mosquito   454 QDGVPILKKEVSGDASEAALLKCMELALGDVLSIRKRNKKVCEIPFNSTNKYQVSIHETEDPSDP 518

  Fly   520 RYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYP 584
            |||||||||||||||||||||||||||::||||||||||||:|||||||||||||||||||||||
Mosquito   519 RYLLVMKGAPERILERCSTIFINGKEKLMDEEMKEAFNNAYLELGGLGERVLGFCDFMLPSDKYP 583

  Fly   585 NGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSV 649
            .|||||:||:||.:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   584 VGFKFNSDDVNFQVDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSV 648

  Fly   650 GIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQ 714
            ||||||||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||||
Mosquito   649 GIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGSELRDLSSDQLDEILRYHTEIVFARTSPQ 713

  Fly   715 QKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTG 779
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   714 QKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTG 778

  Fly   780 VEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEH 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   779 VEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEH 843

  Fly   845 AEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWD 909
            ||:|||||||||||||||||.|||||||||||||||||||||||||||||||||.||||:||.||
Mosquito   844 AESDIMKRPPRDPFNDKLVNERLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPLKLFGLRKSWD 908

  Fly   910 SKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNF 974
            |||:||||||||||||||||||||:|||||||:|||||||||||||||||||||.||||||||||
Mosquito   909 SKAINDLTDSYGQEWTYRDRKTLEFTCHTAFFVSIVVVQWADLIICKTRRNSIFHQGMRNWALNF 973

  Fly   975 GLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQET 1039
            ||||||||||.|||.|||:|||||||||.|||.||:||:|:||:|||.|||||||||||||||||
Mosquito   974 GLVFETVLAAILSYTPGMDKGLRMYPLKFVWWLPALPFSLSIFVYDEIRRFYLRRNPGGWLEQET 1038

  Fly  1040 YY 1041
            ||
Mosquito  1039 YY 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	943/995 (95%)
		Cation_ATPase_N	58..132	CDD:214842	69/73 (95%)
		E1-E2_ATPase	152..383	CDD:278548	224/230 (97%)
		Cation_ATPase	445..539	CDD:289987	86/93 (92%)
		COG4087	<695..770	CDD:226572	74/74 (100%)
		Cation_ATPase_C	817..1025	CDD:279079	188/207 (91%)
AgaP_AGAP002858	XP_003436267.1	ATPase-IIC_X-K	44..1040	CDD:273445	944/997 (95%)
		Cation_ATPase_N	57..131	CDD:214842	69/73 (95%)
		E1-E2_ATPase	151..382	CDD:278548	224/230 (97%)
		Cation_ATPase	444..538	CDD:289987	86/93 (92%)
		COG4087	<694..769	CDD:226572	74/74 (100%)
		Cation_ATPase_C	816..1024	CDD:279079	188/207 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I1023
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113729
Inparanoid	1	1.050	1956	1.000	Inparanoid score	I170
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		oto108024
Panther	1	1.100	-	-	LDO	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X416
TreeFam	0	0.000	Not matched by this tool.
	11	11.080