DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and AgaP_AGAP011271

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	XP_309375.4	Gene:	AgaP_AGAP011271 / 1270659	VectorBaseID:	AGAP011271	Length:	1278	Species:	Anopheles gambiae

Alignment Length:	1314	Identity:	268/1314 - (20%)
Similarity:	441/1314 - (33%)	Gaps:	426/1314 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DSYRVATVIATDDD--NRTADGQYKSRRKMPAKVNKKENLDDLKQE-----------LD---IDF 61
            |.|.|..||....|  ....|    |.:|.|:..|.:..:.:|.|.           ||   :.:
Mosquito   106 DLYYVKDVITLSGDVVREIVD----SEKKKPSSPNARNVIKELTQNGIPDYGAFLRTLDPFQVAY 166

  Fly    62 HKISPEELYQRFQTH---------------------------------PENGLSHAKAKENLERD 93
            |:..     .||: |                                 |...:.|.|.....|:.
Mosquito   167 HRTG-----GRFE-HASTMRYFSCKKLRYIWCDQAKKFVKLQGLDVEVPSVLIHHTKGLSVYEQS 225

  Fly    94 ------GPNALTPPKQTPEWVKFCKNL-----FGGFAMLLWIGAILCFVAYSIQASTSEEPADDN 147
                  |.|.:..|.::...:.|.:.|     |..|:::||.     |..|...|
Mosquito   226 IRRLIYGSNEIFIPLRSVLTLLFLEVLNPFYVFQIFSVVLWF-----FYEYYYYA---------- 275

  Fly   148 LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVK 212
                    .|:|:...|..     :..|:::.:|....::||......:.:|  |.:|.:.:|.:
Mosquito   276 --------VVIILMSAFGI-----TVSIIQTQRNQRALYSTVRSTDTAMVVR--DTMLSESIETR 325

  Fly   213 FGDRIPADIRIIEAR-------------NFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFS 264
            |  .:|.|:..|.|.             |..:|.|.|||||.|.::       .||..:....:
Mosquito   326 F--LVPGDVLEIPATGCTMQCDAVLLSGNCILDESMLTGESVPVTK-------TPLPLRRDLIY- 380

  Fly   265 TNAVEGTAKGVVISCGDHTVMGRIAG----LASGLDTGE--------------TPI----AKEIH 307
             |..|....  .:.||...:..|..|    |...|:||.              .|:    .|:.:
Mosquito   381 -NRKEHARH--TLFCGTRVIQTRYIGSEKVLVKVLNTGNITAKGGLVRSILYPPPVDYKFEKDSY 442

  Fly   308 HFIHLITGVAVFLGVTFFV---IAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRM 369
            .|| .:.|:..|.|..:.:   |:..:|.  :..::..:.:|...||..|.|.:||......||:
Mosquito   443 KFI-TVLGIVAFCGFVYTLYTKISRSIGA--VKIIVESLDLITIAVPPALPAAMTVGRMYAQKRL 504

  Fly   370 ASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSP 434
            ...|....:..|:...||...:|.|||||||::.:   .||   .::..|:|   :..|..
Mosquito   505 KRSNIYCISPRAINVSGSIDCVCFDKTGTLTEDGL---DMW---GVLPKDST---NSFQIP---- 556

  Fly   435 GFKALSRI---------ATLCNRAEFKGGQ-DGVP-----------ILKKEVSGDASEAALL--- 475
             .|.:.|:         ...|:...|..|: .|.|           ||::....|.::..:|
Mosquito   557 -LKDVGRLPMSDHLLFGMVTCHSITFVNGEMRGDPLDLKIFESTGWILEEANVSDETKYDMLFPT 620

  Fly   476 --------KCMELAL---------GDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLL 523
                    .|.||.|         .|:..:|:         |:.|:..|.....|...:|..:.:
Mosquito   621 IVKPPRGDSCDELNLELDVAYDNSNDIGIVRE---------FSFTSALQRMSVVTRKVSDNHFNV 676

  Fly   524 VMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDK---YPN 585
            .:||:||.|...|.           .|.:.|.|.:........|.|::......|  ||   ||.
Mosquito   677 YVKGSPEMISSLCR-----------PESIPEDFQSKLGFYAHQGYRIIAIAYKQL--DKKLNYPK 728

  Fly   586 GFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVG 650
            ..|...:.:...::.|.||.|.:.:   :....:.:....:|.|:.:|||||:.:||.::|...|
Mosquito   729 VQKIAREKVECELEFLGFVILENRL---KTDTEEVIESLNAANIRSVMVTGDNLLTAASVAHDCG 790

  Fly   651 IISEGNE--TVEDIAQRLN---------------------------------------------- 667
            :|..|..  ||...|.:.|
Mosquito   791 MILAGQNLVTVTAHADKANPDRYFLSYDITGQPQLTQSDIMNDNQVDGSVGGKPDGPVRAKENGN 855

  Fly   668 -IPVSEVN----------------PREAKAAVVHG----------------------AELRDVSS 693
             :|::|.|                .:|.:..|.:|                      |.:.:...
Mosquito   856 YVPMTESNSISSSIDTCTITTQLSDKEHRIVVANGVPGKLGPGGGSSFRFALTGKTWAIINEHFP 920

  Fly   694 DQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSD 758
            :.:..|..|.|  ||||.||.||..::.|.|::|..||:.|||.||..|||.|..|:::..|.|.
Mosquito   921 ELVSTITTYGT--VFARMSPDQKQHLITGLQQLGYYVAMCGDGANDCGALKAAHTGISLSEAESS 983

  Fly   759 VSKQAADMILLDDNFASIVTGVEEGRLI----FDNLKKSIAYTLTSNIPEISPFLAFILCDIPLP 819
            |   |:.....:...|.:...::|||..    |...|...||:|......:      ||..|...
Mosquito   984 V---ASPFTSKNPTIACVPNVIKEGRAALVTSFGIFKFMAAYSLVQFASVV------ILYSIDSN 1039

  Fly   820 LGTVTILCIDLGTDMVPAISLAYEHA-EADIMKRPPRDPFNDKLVNSRLISMAYGQ---IGMIQA 880
            |.....|.|||....:.|.......: :..::|:.|.   |..:..:.|:|:|...   |||..|
Mosquito  1040 LTDWQYLYIDLFIISIVAFFFGKTSSYDGPLVKQTPS---NSLISLAPLLSLALHMMVAIGMQLA 1101

  Fly   881 AAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIV 945
            .     ::.:.|:..|.|......|::.|.....:.|             ....:|:....::||
Mosquito  1102 G-----WYHVQAQPWFEPFNYTSDRELNDHGCFENYT-------------IFAISCYQYLILAIV 1148

  Fly   946 VVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGM--------------EKGL 996
            ..:.|..      |.|||.    |:.....::....:|..|:..|..              |...
Mosquito  1149 FSKGAPY------RKSIFS----NYGFIISILVNVAIAIVLTVYPPAWIAEQFELVMPPDGEFRF 1203

  Fly   997 RMYPLKLVWWFPAIPFALAIF----IYDE---------------TRRFYLR---------RNPG- 1032
            |:|.:.    :..|.|.|::|    |.||               :||.||:         .:|.
Mosquito  1204 RLYLVA----YGLINFLLSMFIETVIVDEIAFKRLRYRWHNVAKSRRKYLQIQHNFQRDIHSPSD 1264

  Fly  1033 -----GWLEQETYY 1041
                 ||..::..|
Mosquito  1265 FKTVFGWSSEKYDY 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	257/1278 (20%)
		Cation_ATPase_N	58..132	CDD:214842	19/120 (16%)
		E1-E2_ATPase	152..383	CDD:278548	57/268 (21%)
		Cation_ATPase	445..539	CDD:289987	26/125 (21%)
		COG4087	<695..770	CDD:226572	30/74 (41%)
		Cation_ATPase_C	817..1025	CDD:279079	45/244 (18%)
AgaP_AGAP011271	XP_309375.4	P5-ATPase	38..>117	CDD:289194	5/10 (50%)
		P-ATPase-V	53..1205	CDD:273738	251/1235 (20%)
		Cation_ATPase_N	<214..268	CDD:295564	12/58 (21%)
		E1-E2_ATPase	276..517	CDD:278548	56/263 (21%)
		Cation_ATPase	<649..690	CDD:289987	11/49 (22%)
		Ferritin_like	<681..>744	CDD:294190	15/75 (20%)
		HAD_like	<935..985	CDD:304363	23/52 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910