DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp4a

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001277556.1	Gene:	Atp4a / 11944	MGIID:	88113	Length:	1034	Species:	Mus musculus

Alignment Length:	1033	Identity:	621/1033 - (60%)
Similarity:	777/1033 - (75%)	Gaps:	1/1033 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRADSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQ 74
            |:|::|.:.:|............:...::.......|||.|:::|:|::|:.|::|..||.|::|
Mouse     2 GKAENYELYSVELGSGPGGDMTAKMSKKKAGGGGGKKKEKLENMKKEMEINDHQLSVSELEQKYQ 66

  Fly    75 THPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQAST 139
            |....||..:.|.|.|.|||||||.||:.|||:|||.:.|.||...|:|:.|.:|.:|::||||.
Mouse    67 TSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASE 131

  Fly   140 SEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLV 204
            .:...||||||.:.|.|||:|||.|.||||.||:.|:.||||:|||.|||||:|:|..:.|:.||
Mouse   132 GDLTTDDNLYLAVALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLV 196

  Fly   205 LGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVE 269
            :||:||:|.|||:||||||:.|:..||||||||||||||:|..|.|||:||||:|:|||||..:|
Mouse   197 VGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLE 261

  Fly   270 GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYH 334
            |||:|:|:|.||.|::||||.||||::..:||||.||.||:.:|.|:|:..|.||||:|..:||.
Mouse   262 GTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYT 326

  Fly   335 WLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 399
            :|.|::|.:.|:||.|||||||||||||:|||||:|||||:||||||||||||||.|||||||||
Mouse   327 FLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTL 391

  Fly   400 TQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKE 464
            |||||||:|:||||.|..|||||||||..:|::|..::||.|:.||||||.||.|||.||:.|:.
Mouse   392 TQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRI 456

  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAP 529
            |.|||||.||||..||.||:.|..|.|..|:.|:||||.||:|:|||..||..|.|:||||||||
Mouse   457 VIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSINKFQLSIHTLEDPRDSRHLLVMKGAP 521

  Fly   530 ERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI 594
            ||:|||||:|.|.|:|..|||:.:|||..||:.||||||||||||...|....||.|:.|:.:.:
Mouse   522 ERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAM 586

  Fly   595 NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETV 659
            |||...|.|.||:||||||||.|||||.|||:|||:||||||||||||||||.||||||||:|||
Mouse   587 NFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETV 651

  Fly   660 EDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQ 724
            ||||.||.:||.:||.::|:|.|::|.:|:|:...:|.|.||.|.|:|||||||||||:|||.||
Mouse   652 EDIAARLRMPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQ 716

  Fly   725 RMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 789
            |:||||||||||||||||||||||||||||||||.:|.|||||||||||||||||||:|||||||
Mouse   717 RLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDN 781

  Fly   790 LKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPP 854
            ||||||||||.||||::|:|.:|...:|||||.:|||.|:|.||:.|::|||||.||:|||...|
Mouse   782 LKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRP 846

  Fly   855 RDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDS 919
            |:|..|:|||..|.:.:|.|||.||:.|||..||..||:.|:.|....|:|..|:...:.||.||
Mouse   847 RNPKRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDS 911

  Fly   920 YGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQG-MRNWALNFGLVFETVLA 983
            ||||||:..|...:|||:|.|||||.:.|.||::|.||||.|:|||| .||..|...:||:..:.
Mouse   912 YGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSVFQQGFFRNKILVIAIVFQVCIG 976

  Fly   984 AFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            .||.|||||.......|::..||...:||.|.||:|||.|:..:|..||.|.:||.||
Mouse   977 CFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	615/996 (62%)
		Cation_ATPase_N	58..132	CDD:214842	35/73 (48%)
		E1-E2_ATPase	152..383	CDD:278548	148/230 (64%)
		Cation_ATPase	445..539	CDD:289987	61/93 (66%)
		COG4087	<695..770	CDD:226572	62/74 (84%)
		Cation_ATPase_C	817..1025	CDD:279079	106/208 (51%)
Atp4a	NP_001277556.1	H-K_ATPase_N	2..>27	CDD:286172	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40		1/25 (4%)
		ATPase-IIC_X-K	42..1034	CDD:273445	612/991 (62%)
		Cation_ATPase_N	50..124	CDD:214842	35/73 (48%)
		E1-E2_ATPase	156..375	CDD:278548	141/218 (65%)
		Cation_ATPase	437..531	CDD:289987	61/93 (66%)
		COG4087	616..>742	CDD:226572	93/125 (74%)
		Cation_ATPase_C	809..1018	CDD:279079	106/208 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830