DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and Atp2a1

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_031530.2	Gene:	Atp2a1 / 11937	MGIID:	105058	Length:	994	Species:	Mus musculus

Alignment Length:	1068	Identity:	319/1068 - (29%)
Similarity:	492/1068 - (46%)	Gaps:	184/1068 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 HKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGA 126
            |..|.||....|......||:..:.|.:||:.|||.|...:....|....:........:|.:.|
Mouse     5 HSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAA 69

  Fly   127 ILCFVAYSIQ-----ASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQF 186
            .:.||....:     .:...||        .|:..::|...|...:||..:...:|:.|...|:.
Mouse    70 CISFVLAWFEEGEETVTAFVEP--------FVILLILIANAIVGVWQERNAENAIEALKEYEPEM 126

  Fly   187 ATVIREGEKLT--LRAEDLVLGDVVEVKFGDRIPADIRI--IEARNFKVDNSSLTGESEPQSRGA 247
            ..|.|...|..  ::|.|:|.||:|||..||::||||||  |::...:||.|.|||||.     :
Mouse   127 GKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESV-----S 186

  Fly   248 EFTHENPL--------ETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAK 304
            ...|.:|:        :.||:.|..||...|.|.|:|.:.|..|.:|:|....:..:..:||:.:
Mouse   187 VIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQ 251

  Fly   305 EIHHFIHLITGVAVFLGVTFFVIAF------ILGYHWLDAVIF----LIGIIVANVPEGLLATVT 359
            ::..|...::.|...:.|..::|..      :.|..|....|:    .:.:.||.:||||.|.:|
Mouse   252 KLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVIT 316

  Fly   360 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQI--------- 415
            .||.|..:|||.||.:|::|.:|||||.||.||||||||||.|:|:|..|:..:::
Mouse   317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNE 381

  Fly   416 --IEADTTEDQSGV----------QYDRTSPGFKALSRIATLCNRA-----EFKGGQDGVPILKK 463
              |...|...:..|          |||    |...|:.|..|||.:     |.||..:.|
Mouse   382 FSITGSTYAPEGEVLKNDKPVRAGQYD----GLVELATICALCNDSSLDFNETKGVYEKV----- 437

  Fly   464 EVSGDASEAALLKCMELALGDVMN------------------IRKRNKKIAEVPFNSTNKYQVSI 510
               |:|:|.||...:|..  :|.|                  ||:..||...:.| |.::..:|:
Mouse   438 ---GEATETALTTLVEKM--NVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEF-SRDRKSMSV 496

  Fly   511 HETEDTNDPRYL---LVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLG 572
            :.:...:....:   :.:|||||.:::||:.:.:......|...:||...:...| .|.|...|.
Mouse   497 YCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKE-WGTGRDTLR 560

  Fly   573 FCDFMLPSDKYPNGFKFNTDD----INFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIM 633
             |..:...|..|...:...||    :.:.:| |.|||::.|:||||..|..::..||.|||:|||
Mouse   561 -CLALATRDTPPKREEMVLDDSAKFMEYEMD-LTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIM 623

  Fly   634 VTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDE 698
            :|||:..||.||.:.:||.|| ||.|.|.|..                   |.|..|:...:..|
Mouse   624 ITGDNKGTAIAICRRIGIFSE-NEEVTDRAYT-------------------GREFDDLPLAEQRE 668

  Fly   699 ILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQA 763
            ..|  ....|||..|..|..|||..|....|.|:|||||||:||||||:||:||| :|:.|:|.|
Mouse   669 ACR--RACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTA 730

  Fly   764 ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCI 828
            ::|:|.||||::||..|||||.|::|:|:.|.|.::||:.|:..........:|..|..|.:|.:
Mouse   731 SEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWV 795

  Fly   829 DLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIG------MIQAAAGFFVY 887
            :|.||.:||.:|.:...:.|||.||||.| .:.|::..|. ..|..||      .:.|||.:|:|
Mouse   796 NLVTDGLPATALGFNPPDLDIMDRPPRSP-KEPLISGWLF-FRYMAIGGYVGAATVGAAAWWFLY 858

  Fly   888 FVIMAENGFLPKKLFGIRKMWDSKAVNDLT-----DSYGQEWTYRDRKTLEYTCHTAFFISIVV- 946
                ||:|             ...:.:.||     ..:..|:...|.:..|........:|::|
Mouse   859 ----AEDG-------------PHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVT 906

  Fly   947 VQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMY--PLKLVW---- 1005
            ::..:.:...:...|:.:  |..| :|..|:....|:..|.:       |.:|  ||.:::
Mouse   907 IEMCNALNSLSENQSLLR--MPPW-VNIWLLGSICLSMSLHF-------LILYVDPLPMIFKLRA 961

  Fly  1006 -----WFPAIPFALAIFIYDETRRFYLR 1028
                 |...:..:|.:...||..:|..|
Mouse   962 LDFTQWLMVLKISLPVIGLDELLKFIAR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	319/1068 (30%)
		Cation_ATPase_N	58..132	CDD:214842	18/69 (26%)
		E1-E2_ATPase	152..383	CDD:278548	78/252 (31%)
		Cation_ATPase	445..539	CDD:289987	29/119 (24%)
		COG4087	<695..770	CDD:226572	37/74 (50%)
		Cation_ATPase_C	817..1025	CDD:279079	53/230 (23%)
Atp2a1	NP_031530.2	P-type_ATPase_SERCA	5..989	CDD:319778	318/1066 (30%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		7/19 (37%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920